Antimicrobial resistance among pathogenic bacteria from mink (Neovison vison) in Denmark

Abstract

BackgroundFor proper treatment of bacterial infections in mink, knowledge of the causative agents and their antimicrobial susceptibility patterns is crucial. The used antimicrobials are in general not registered for mink, i.e. most usage is “off-label”. In this study, we report the patterns of antimicrobial resistance among pathogenic bacteria isolated from Danish mink during the period 2014–2016. The aim of this investigation was to provide data on antimicrobial resistance and consumption, to serve as background knowledge for new veterinary guidelines for prudent and optimal antimicrobial usage in mink.ResultsA total number of 308 Escherichia coli isolates, 41 Pseudomonas aeruginosa, 36 Streptococcus canis, 30 Streptococcus dysgalactiae, 55 Staphylococcus delphini, 9 Staphylococcus aureus, and 20 Staphylococcus schleiferi were included in this study. Among E. coli, resistance was observed more frequently among the hemolytic isolates than among the non-hemolytic ones. The highest frequency of resistance was found to ampicillin, 82.3% and 48.0% of the hemolytic of the non-hemolytic isolates, respectively. The majority of the P. aeruginosa isolates were only sensitive to ciprofloxacin and gentamicin. Among the Staphylococcus spp., the highest occurrence of resistance was found for tetracycline. Regarding the nine S. aureus, one isolate was resistant to cefoxitin indicating it was a methicillin-resistant Staphylococcus aureus. Both β-hemolytic Streptococcus species showed high levels of resistance to tetracycline and erythromycin. The antimicrobial consumption increased significantly during 2007–2012, and fluctuated at a high level during 2012–2016, except for a temporary drop in 2013–2014. The majority of the prescribed antimicrobials were aminopenicillins followed by tetracyclines and macrolides.ConclusionsThe study showed that antimicrobial resistance was common in most pathogenic bacteria from mink, in particular hemolytic E. coli. There is a need of guidelines for prudent use of antimicrobials for mink.Electronic supplementary materialThe online version of this article (doi:10.1186/s13028-017-0328-6) contains supplementary material, which is available to authorized users.

Molecular and Phenotypic Characteristics ofEscherichia coliIsolates from Farmed Minks in Zhucheng, China

“…foxes in Portugal [37] but was not consistent with a report on minks in Denmark, which may be due to differences in geography and rearing conditions [38]. Most isolates were resistant to ampicillin (46/50, 92.0 %) and tetracycline (45/50, 90.0 %), which was similar to a report on minks in Denmark [38,39], but the percentage of resistance to ampicillin and tetracycline was much higher than that of Pedersen's study (59.1 % and 75.5 %) [38]. Our study showed that 43 isolates (43/50, 86.0 %) were MDR, which was much higher than the MDR rate in minks in Denmark (60 %) [38].…”

Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by theStreptococcus canisM protein SCM

“…Streptococcus canis is a frequent colonizer of mucosal surfaces and the skin of dogs and cats, and occasionally identified in various other host species such as cows, rats, minks, mice, rabbits, and foxes [1][2][3][4][5][6]. As an opportunistic pathogen, S. canis infections generally lead to local and self-limiting alterations of skin and mucosa, but in some cases can proceed to severe and life-threatening diseases, such as streptococcal toxic shock-like syndrome (STSLS), necrotizing fasciitis (NF), meningitis and septicemia [7][8][9][10].…”

Characterization of Staphylococcus intermedius Group Isolates Associated with Animals from Antarctica and Emended Description of Staphylococcus delphini

“…Type strains of S. delphini CCM 4115 T , S. intermedius CCM 5739 T , S. pseudintermedius CCM 7315 T , and S. cornubiensis CCM 8997 T were acquired from the Czech Collection of Microorganisms (Brno, Czech Republic). Reference strains of S. delphini: Nono ( = CCM 4184) /dolphin/, CCM 2618 ( = CCUG 51769) /mink/, P12548, P12549, and P12550 ( = 16-9169-2, 17-7762-1, and 18-3863-5, respectively) /all from minks/ [37], P12456 ( = HT 2030677) /camel/, P12457 and P12458 ( = 8086 and 9106) /both from horses/ [11] and CCM 8998 ( = MI 18-1587) /human/ [36] were described previously and kindly provided by the authors.…”