Antimicrobial resistance among clinical <i>Vibrio cholerae</i> non-O1/non-O139 isolates: systematic review and meta-analysis

Wu, Qianxing; Vaziri, Ali; Omidi, Nazanin; Kaviar, Vahab Hassan; Maleki, Afshin; Khadivar, Parand; Kouhsari, Ebrahim

doi:10.1080/20477724.2022.2114620

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…The low/medium resistance against eleven antibiotics [meropenem, imipenem, cefotaxime, kanamycin, azithromycin, chloramphenicol, ciprofloxacin, nalidixic acid, nitrofurantoin, trimethoprim and cotrimoxazole] by the O1/non-O139 strains recorded in this study is similar to most of the earlier reports [54,108,110,117,118,120,127,128,131,132] although with some differences. A low/medium resistance observed against nalidixic acid by [120,132], azithromycin by [131], cefotaxime by [132], imipenem by [108,132], cotrimoxazole by [108,118,120,131,132], chloramphenicol by [116,120,132], ciprofloxacin by [116,120,132] and kanamycin by [116,120] was as observed in this study. However, in some other reports, no V. cholerae non-O1/non-O139 isolate exhibited resistance against nalidixic acid [110,117,128], meropenem [108,118], cefotaxime [108,117,118], imipenem [116][117][118], nitrofurantoin [108], cotrimoxazole [110,…”

Section: Plos Onesupporting

confidence: 87%

“…Gentamycin and amikacin interfere with protein synthesis, ofloxacin affect DNA synthesis while cefuroxime interferes with cell wall synthesis. Earlier studies have shown that V. cholerae non-O1/non-O139 are generally susceptible to the four antibiotics [43,61,63,108,[116][117][118][119][120]. To interpret other susceptibility/resistance patterns for the remaining panel of antibiotics, resistance to an antibiotic was referred to as low to medium when the population that exhibited resistance against it is < 50% [121] and high when the population is > = 50% [122].…”

Section: Plos Onementioning

confidence: 99%

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Antibiotic resistance and virulence genes profiling of Vibrio cholerae and Vibrio mimicus isolates from some seafood collected at the aquatic environment and wet markets in Eastern Cape Province, South Africa

Abioye,

Nontongana,

Osunla

et al. 2023

PLoS ONE

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The current study determines the density of Vibrio spp. and isolates V. cholerae and Vibrio mimicus from fish-anatomical-sites, prawn, crab and mussel samples recovered from fish markets, freshwater and brackish water. Virulence and antibiotic resistance profiling of isolates were carried out using standard molecular and microbiology techniques. Vibrio spp. was detected in more than 90% of samples [134/144] and its density was significantly more in fish than in other samples. Vibrio. cholerae and V. mimicus were isolated in at least one sample of each sample type with higher isolation frequency in fish samples. All the V. cholerae isolates belong to non-O1/non-O139 serogroup. One or more V. cholerae isolates exhibited intermediate or resistance against each of the eighteen panels of antibiotics used but 100% of the V. mimicus were susceptible to amikacin, gentamycin and chloramphenicol. Vibrio cholerae exhibited relatively high resistance against polymyxin, ampicillin and amoxicillin/clavulanate while V. mimicus isolates exhibited relatively high resistance against nitrofurantoin, ampicillin and polymixin. The multiple-antibiotic-resistance-index [MARI] for isolates ranges between 0 and 0.67 and 48% of the isolates have MARI that is >0.2 while 55% of the isolates exhibit MultiDrug Resistance Phenotypes. The percentage detection of acc, ant, drf18, sul1, mcr-1, blasvh, blaoxa, blatem, blaoxa48, gyrA, gyrB and parC resistance-associated genes were 2%, 9%, 14%, 7%, 2%, 25%, 7%, 2%, 2%, 32%, 25% and 27% respectively while that for virulence-associated genes in increasing other was ace [2%], tcp [11%], vpi [16%], ompU [34%], toxR [43%], rtxC [70%], rtxA [73%] and hyla [77%]. The study confirmed the potential of environmental non-O1/non-O139 V. cholerae and V. mimicus to cause cholera-like infection and other vibriosis which could be difficult to manage with commonly recommended antibiotics. Thus, regular monitoring of the environment to create necessary awareness for this kind of pathogens is important in the interest of public health.

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Section: Plos Onesupporting

confidence: 87%

Section: Plos Onementioning

confidence: 99%

Antibiotic resistance and virulence genes profiling of Vibrio cholerae and Vibrio mimicus isolates from some seafood collected at the aquatic environment and wet markets in Eastern Cape Province, South Africa

Abioye,

Nontongana,

Osunla

et al. 2023

PLoS ONE

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“… 17 Compared with the CARD database, the drug resistance genes detected in VC1115 strain were CRP, catB9, almF, almG, almE, MCR-4.3, and QnrVC5 . The drug sensitivity test results indicated that the VC1115 strain exhibited susceptibility to sulfonamides, quinolones, aminoglycosides, and other antibiotics while demonstrating resistance to cefazolin, imipenem, and polymyxin B. Wu et al 18 reported that the resistance rates of 824 clinical NOVC isolates worldwide were ampicillin (44%), streptomycin (40%), cotrimoxazole (27%), and neomycin (27%). It shows that there are some differences in the drug sensitivity of NOVC strains.…”

Section: Discussionmentioning

confidence: 99%

Whole Genome Analysis of a Non-O1, Non-O139 Vibrio cholerae Detected from Human Blood in China

Tang,

Li,

Zhang

et al. 2023

IDR

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Non-O1, non-O139 Vibrio cholerae (NOVC) can cause cholera-like diarrhea, but it rarely causes extraintestinal infection, so it is easily overlooked. In this report, we present a case of NOVC detected through blood culture in a 58-year-old male patient with cirrhosis, resulting in severe infection. The patient had been diagnosed with cirrhosis seven years prior and was admitted to the hospital due to abdominal distension and gastrointestinal bleeding. Gram-negative bacilli were isolated from blood cultures and identified as V. cholerae using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and average nucleotide identity (ANI). Moreover, the serum agglutination test showed that the strain was non-O1/non-O139. Further whole genome sequencing and analysis of the strain showed that the strain mainly carried virulence genes tox R, RTX, hly A, T3SS/T6SS , but no resistant genes such as sulII, dfrA1, strB were detected. It provides information for the study of the pathogenic mechanism and drug resistance mechanism of V. cholerae . The patient had severe symptoms and a poor prognosis, indicating that although the NOVC strain infected in this patient had few virulence genes, it was not weak in pathogenicity. It may be caused by the effect of some virulence genes, which should be paid attention to.

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“…Duodenal fluid aspiration after a fatty meal clearly indicated the high presence of V. cholerae [ 37 ]. The persistence of V. cholerae in the biliary tract may be due to the production of biofilms in the presence of bile [ 38 ], which may form around gallstones. In our patient, subsequent bacteremic events required the formation of biofilms to allow for bacterial persistence over the course of months.…”

Section: Discussionmentioning

confidence: 99%

Duped by dumping syndrome: non-endemic Vibrio cholerae bacteremia in an immunocompetent host with gastric bypass surgery, a case report

Reyes,

Pecora,

Weiss

2023

Access Microbiology

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Extra-intestinal infection with non-O1/non-O139 strains of Vibrio cholerae (NOVC) is rare, though bacteremia and hepatobiliary manifestations have been reported. Reduced stomach acid, or hypochlorhydria, can increase risk of V. cholerae infection. We describe a 42-year-old woman with hypochlorhydria due to untreated Helicobacter pylori infection, gastric-bypass surgery, and chronic proton pump inhibitors (PPI) exposure, who developed acute diarrhoea following raw oyster consumption. Her symptoms were attributed to rapid gastric emptying (dumping syndrome) after a negative limited stool work-up. She had persistent diarrhoea, weight loss, and after 5 months was admitted with acute cholecystitis and NOVC bacteremia, requiring cholecystectomy. This is the first reported case of NOVC bacteremia and cholecystitis in a patient with gastric bypass. This case highlights the potential for NOVC biliary carriage, the role of hypochlorhydria as a risk factor for Vibrio infection, and the importance of excluding infectious diarrhoea in patients with new onset of symptoms compatible with dumping syndrome and a relevant travel history.

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Antimicrobial resistance among clinical Vibrio cholerae non-O1/non-O139 isolates: systematic review and meta-analysis

Cited by 4 publications

References 37 publications

Antibiotic resistance and virulence genes profiling of Vibrio cholerae and Vibrio mimicus isolates from some seafood collected at the aquatic environment and wet markets in Eastern Cape Province, South Africa

Antibiotic resistance and virulence genes profiling of Vibrio cholerae and Vibrio mimicus isolates from some seafood collected at the aquatic environment and wet markets in Eastern Cape Province, South Africa

Whole Genome Analysis of a Non-O1, Non-O139 Vibrio cholerae Detected from Human Blood in China

Duped by dumping syndrome: non-endemic Vibrio cholerae bacteremia in an immunocompetent host with gastric bypass surgery, a case report

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