Antimicrobial Resistance: A Challenge for the Future

Varaldo, Pietro E.; Facinelli, Bruna; Bagnarelli, Patrizia; Menzo, Stefano; Mingoia, Marina; Brenciani, Andrea; Giacometti, Andrea; Barchiesi, Francesco; Brescini, Lucia; Cirioni, Oscar; Scalise, Giorgio; Barbadoro, Pamela; Stanislao, Francesco Di; Prospero, Emilia; D’Errico, Marcello Mario

doi:10.1007/978-3-030-33832-9_2

Cited by 5 publications

(2 citation statements)

References 123 publications

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“…Since their breakthrough discovery, antibiotics held the promise of treating and controlling infectious diseases, triggering the massive rise of antibiotic usage in all applicative fields, including the common animal husbandry practices [69,70].…”

Section: Domestic Animal Husbandry Influence On Amrmentioning

confidence: 99%

Antimicrobial Resistance in Veterinary Medicine: An Overview

Palma

Tilocca

Roncada

2020

IJMS

169

100

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Antimicrobial resistance (AMR) represents one of the most important human- and animal health-threatening issues worldwide. Bacterial capability to face antimicrobial compounds is an ancient feature, enabling bacterial survival over time and the dynamic surrounding. Moreover, bacteria make use of their evolutionary machinery to adapt to the selective pressure exerted by antibiotic treatments, resulting in reduced efficacy of the therapeutic intervention against human and animal infections. The mechanisms responsible for both innate and acquired AMR are thoroughly investigated. Commonly, AMR traits are included in mobilizable genetic elements enabling the homogeneous diffusion of the AMR traits pool between the ecosystems of diverse sectors, such as human medicine, veterinary medicine, and the environment. Thus, a coordinated multisectoral approach, such as One-Health, provides a detailed comprehensive picture of the AMR onset and diffusion. Following a general revision of the molecular mechanisms responsible for both innate and acquired AMR, the present manuscript focuses on reviewing the contribution of veterinary medicine to the overall issue of AMR. The main sources of AMR amenable to veterinary medicine are described, driving the attention towards the indissoluble cross-talk existing between the diverse ecosystems and sectors and their cumulative cooperation to this warning phenomenon.

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Section: Domestic Animal Husbandry Influence On Amrmentioning

confidence: 99%

Antimicrobial Resistance in Veterinary Medicine: An Overview

Palma

Tilocca

Roncada

2020

IJMS

169

100

View full text Add to dashboard Cite

show abstract

“…The growing incidence of antimicrobial resistance (AMR) due to various factors has brought about recent massive outbreaks of infectious epidemics, topping as the most complex global health crisis [6]. The World Health Organization (WHO) has since called for urgent corrective actions including expansion of effective antibacterial therapies [7].…”

Section: Introductionmentioning

confidence: 99%

Morphological alterations in gram-positive and gram-negative bacteria exposed to minimal inhibitory and bactericidal concentration of raw Malaysian stingless bee honey

Yaacob

Wahab

Huyop

et al. 2020

Biotechnology & Biotechnological Equipment

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The stingless bee Heterotrigona itama honey is generating interest among consumers due to unique antibacterial properties. Despite the substantial health benefits of this honey, its action mode of inhibiting and killing pathogenic bacteria remains unresolved. The present study aimed to unravel the effect of raw H. itama honey against four clinically important bacteria, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. Total phenolic and total flavonoid contents, alongside antioxidant and antibacterial activities of honey samples were established to identify the 'best' raw honey. Honey Sy-1 showing the highest amount of phenolics (80.71 mg GAE/100 g) and antioxidant capacity (82.67%) and, the lowest MIC (1.56% (w/v)) and MBC (3.125% (w/v)), was tested against four bacterial cells, wherein any alterations in cellular morphology were observed under scanning electron microscope. The micrographs revealed significant elongation/filamentation in B. subtilis cells, de-flagellation in P. aeruginosa, membrane perturbation and leakage of intracellular contents in E. coli alongside non-dividing septated cells in S. aureus. H. itama honey inhibited bacterial growth by disrupting the cell membrane in conjunction to interacting with a cytosolic target or possibly interrupted septum formation and blocking DNA and protein syntheses. The evidence strongly supported the natural antibacterial properties of the H. itama honey.

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