Antimicrobial prophylaxis is critical for preventing surgical site infection

Duclos, Gary; Zieleskiewicz, Laurent; Léone, Marc

doi:10.21037/jtd.2017.08.81

Cited by 10 publications

(12 citation statements)

References 14 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The organization should form an interdisciplinary team of key stakeholders to design a standardized process for integrating the current guidelines into established workflows (Table ). According to researchers and clinical practice guidelines, the best timing for prophylactic antibiotic administration is unclear . However, most researchers agree that the antibiotic administration should be complete at the time of incision, and that a range of up to 120 minutes for some antibiotics with longer infusion times before incision is acceptable .…”

Section: Preoperative Antibiotic Timing Process Improvementmentioning

confidence: 99%

“…According to researchers and clinical practice guidelines, the best timing for prophylactic antibiotic administration is unclear . However, most researchers agree that the antibiotic administration should be complete at the time of incision, and that a range of up to 120 minutes for some antibiotics with longer infusion times before incision is acceptable . The Centers for Disease Control and Prevention recommends administration of preoperative antimicrobial agents only when indicated, and that they be timed such that a bactericidal concentration of the agents is established in the serum and tissues when the incision is made.…”

Section: Preoperative Antibiotic Timing Process Improvementmentioning

confidence: 99%

“…Ultimately, optimal preoperative prophylactic antibiotic administration is based on a theoretical principle: the peak of antibiotic concentration at the surgical site should be reached at the time of incision . For this reason, antibiotic administration timing depends on the necessary infusion time and the pharmacokinetics of each antibiotic for each individual patient . Implementing a standardized organizational process that applies to all patients makes this level of individualization extremely difficult and perhaps unnecessary if research continues to support the current recommended range as found in clinical practice guidelines.…”

Section: Preoperative Antibiotic Timing Process Improvementmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Issues—February 2019

Kyle¹

2019

AORN Journal

View full text Add to dashboard Cite

Section: Preoperative Antibiotic Timing Process Improvementmentioning

confidence: 99%

Section: Preoperative Antibiotic Timing Process Improvementmentioning

confidence: 99%

Section: Preoperative Antibiotic Timing Process Improvementmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Issues—February 2019

Kyle¹

2019

AORN Journal

View full text Add to dashboard Cite

“…The guideline will have applicability in all countries and be especially welcomed in developing countries [ 56 , 57 ]. The selection and application of prophylactic antibiotics should be conducted according to medical characteristics including the type of surgical incision, the possibility of infection, the type of potential pathogens and the prophylactic effect of antibiotics [ 58 ]. The best timing for the surgical antibiotics administration depends on the pharmacokinetics of each antibiotic.…”

Section: Antimicrobial Agentsmentioning

confidence: 99%

Application of antimicrobial drugs in perioperative surgical incision

Xiao

Wang

et al. 2018

Ann Clin Microbiol Antimicrob

View full text Add to dashboard Cite

Infection in surgical incision often results in poor wound healing, and one of the main factors for wound infection is the use of antimicrobial agents. Rational use of antibiotics is one of the key factors to prevent incision infection in general surgery. The number of current clinical studies on antibiotic use before and during surgery is greater than that of systematic studies on antibiotic use after surgery. For the rational use of antibiotics and improvement of wound healing rate, researchers around the world have gradually focused on the use of antibiotics after surgery. Despite the familiarity on the concept of “rational use of antibiotics”, few clear and systematic studies were conducted to elucidate the effect of different antibiotics on wound healing. Therefore, this review focuses on the use of different types of antimicrobial agents in surgical wounds.

show abstract

“…In veterinary medicine, non-therapeutic administration of antimicrobials to individual animals is common in companion, bovine and equine medicine to prevent surgical site infections 4,5 . In food animals, antimicrobials are often used to prevent bacterial infections (prophylactically) and also after potential exposure to a pathogen to reduce clinical signs and/or mortality (metaphylactically) 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Effects of prophylactic and therapeutic antimicrobial uses in small-scale chicken flocks

Nguyễn

Bach²,

Phu

et al. 2020

Preprint

View full text Add to dashboard Cite

SynopsisBackgroundAntimicrobials are extensively used both prophylactically and therapeutically in poultry production. Despite this, there are little data on the effect of antimicrobial use (AMU) on disease incidence and mortality rate.ObjectiveWe investigated the relationships between AMU and disease and between AMU and mortality using data from a large (n=322 flocks) cohort of small-scale chicken flocks in the Mekong Delta, Vietnam, that were followed longitudinally from day-old to slaughter (5,566 observation weeks).MethodsWe developed a parameterized algorithm to categorize the observation weeks into ‘non-AMU’, ‘prophylactic AMU’ and ‘therapeutic AMU’. To evaluate the prophylactic AMU effect, we compared the frequencies of clinical signs in ‘non-AMU’ and ‘prophylactic AMU’ periods. To analyse therapeutic AMU, we compared mortality rates between the weeks of disease episodes before and after AMU. Analyses were stratified by clinical signs (4) and antimicrobial classes (13).ResultsProphylactic AMU never reduced the probability of disease, some antimicrobial classes such as lincosamides, amphenicols and penicillins increased the risk. The risk of diarrhoea consistently increased with prophylactic AMU. Therapeutic AMU often had an effect on mortality but the pattern was inconsistent across the combinations of antimicrobial classes and clinical signs with 14/29 decreasing and 11/29 increasing the mortality rate. Lincosamides, methenamines and cephalosporins were the only three antimicrobial classes that always decreased the mortality rate when used therapeutically. Results were robust respective to the parameters values of the weeks categorization algorithm.ConclusionThis information should help support policy efforts and interventions aiming at reducing AMU in animal production.

show abstract

Antimicrobial prophylaxis is critical for preventing surgical site infection

Cited by 10 publications

References 14 publications

Clinical Issues—February 2019

Clinical Issues—February 2019

Application of antimicrobial drugs in perioperative surgical incision

Effects of prophylactic and therapeutic antimicrobial uses in small-scale chicken flocks

Contact Info

Product

Resources

About