Antimicrobial Prophylaxis for Women with First Trimester Vaginal Bleeding Could Reduce the Rate of Miscarriage

Abstract

This is a prospective study conducted to examine the possible benefit of antibiotic prophylaxis in reducing the symptoms of threatened miscarriage as well as decreasing the rate of progression into spontaneous miscarriage in women with first trimester vaginal bleeding. This study was conducted at Al Thawra General Hospital over a year (from Jan. to Dec 2016). Ninety-two women with threatened miscarriage during the first trimester were included (case group) and compared to 90 pregnant women without vaginal bleeding with similar parity and gestational age. Amoxicillin-clavulanate drug was given for all cases of the study group during vaginal bleeding. Both groups were monitored up to 28 weeks gestational age. Among 92 women with threatened miscarriage, only three cases (3.2%) had spontaneous loss (P < 0.001). Vaginal bleeding was significantly relieved within 3 days of antibiotic administration (P < 0.00). Results of this study give evidence that antibiotic prophylaxis for women with threatened miscarriage reduces the amount and duration of vaginal bleeding, and decreases the rate of progression into spontaneous miscarriage.