Antimicrobial Properties of the Constituents of Piper aduncum

Abstract

An ethanol extract of the leaves of Piper aduncum demonstrated good antimicrobial activity. Bioassay-directed fractionation of this extract led to the isolation of 4-methoxy-3,5-bis(3Ј-methylbenzoic acid) 1, 2,6-dihydroxy-4-methoxy-chalcone 2, nervogenic acid 3 and 2,2-dimethoxy-8-(3-methyl-2-butenyl)-2H-chromene-6-carboxylic acid 4. These compounds showed considerable in vitro antifungal and antibacterial activity.Apparatus. Melting points were determined on a Thomas Hoover capillary melting point apparatus and are uncorrected. The IR spectra were obtained with a Perkin-Elmer 281B infrared spectrometer. The 1 H-and 13 C-NMR spectra were obtained using a VXR-300 spectrometer operating at 300 MHz and 75 MHz, respectively. Standard pulse sequences were used for COSY, HETCOR, LR-HETCOR, DEPTGL and APT experiments. Electron impact mass spectra were obtained at the Mass Kansas. TLC analyses were carried out on precoated silica G-25 UV 254 plates (Macherey-Nagel Duren). Visualization of the plates was achieved with a long-wavelength UV lamp. The adsorbent for column chromatography was silica

Antibacterial screening of some Peruvian medicinal plants used in Callería District

“…Benzoic acid and benzene derivates, dihydrochalcones and chromenes isolated from its leaves were active against a variety of microorganisms including Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Cryptococcus neoformans, Mycobacteria intracellulare, Micrococcus luteus and Pseudomonas aeruginosa (Nair and Burke, 1990;Orjala et al, 1993;Orjala et al, 1994;Okunade et al, 1997). The chemical composition of essential oil and its antibacterial properties have also been described (Tirillini et al, 1996;Maia et al, 1998;Pino et al, 2004).…”

The anti-inflammatory activity of dillapiole and some semisynthetic analogues

“…Few studies on the preparation of analogues and the possible therapeutic activities of dillapiole (1) have been published in the literature (Orjala et al, 1993(Orjala et al, , 1994Okunade et al, 1997;Belzile et al, 2000;Majerus et al, 2000;Meléndez & Capriles, 2006;Fazolin et al, 2007;Lobato et al, 2007). As it is an easily extracted natural product with a relatively simple structure and high reactivity, the synthetic manipulation and biological evaluation of dillapiole (1) can easily be planned, developed and executed.…”

3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium

“…A number of other prenylated para-hydroxy-benzoic acid derivatives have been isolated previously from species of various plant families, including Piperaceae (Reynolds, 1986;Ampofo, 1987;Orjala et al, 1993;Rockford, 1994;Okunade, 1997;Tamemoto et al, 2001). Interestingly, they are all parahydroxylated.…”