Antimicrobial Properties of Nanostructured Hydrogel Webs Containing Silver

Wu, Jian; Hou, Shuyu; Ren, Dacheng; Mather, Patrick T.

doi:10.1021/bm900620w

Cited by 102 publications

(66 citation statements)

References 48 publications

(99 reference statements)

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“…This unusual hydrogel can therefore have interesting applications for wound dressings. 417 Despite these promising examples, silver integration does not always lead to better mechanical properties. Thus, Radheshkumar and Munstedt noticed a significant decrease in toughness and elongation strength when 2 wt % silver powder (2 × 10 7 μg kg −1 ) having a specific surface area of 0.78 m 2 g −1 is introduced into polyamide, even though the silver powder was well dispersed.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

et al. 2013

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Introduction 4708 2. Peptides and Silver 4709 2.1. Silver Binding to Amino Acids and Peptides 4709 2.1.1. Silver Binding to Amino Acids − Theory 4709 2.1.2. Silver Binding to Amino Acids − Experiment 4711 2.1.3. Silver Binding to Peptides 4711 2.2. Natural Peptides Involved in Metal Detoxification 4714 2.3. Peptides for the Formation of Silver Nanostructures 4716 2.3.1. Biomineralization of Silver by Means of Peptides 4716 2.3.2. Peptides as Structure-Determining Scaffolds in the Synthesis of Silver Nanostructures 4721 3. Bacteria and Silver 4722 3.1. Antimicrobial Properties of Silver-Containing Compounds 4722 3.1.1. Interactions with the Bacterial Cell Wall 4722 3.1.2. Interactions with DNA, Enzymes, and Membrane Proteins 4724 3.1.3. Generation of Reactive Oxygen Species 4725 3.2. Bacterial Resistance Mechanisms against Ag(I) 4726 3.2.1. Accumulation and Storage-Based Mechanism 4726 3.2.2. Efflux Pump-Based Mechanism 4727 3.3. Synthesis of Silver Nanoparticles by Means of Bacteria 4728 4. Silver-Based Biomaterials in the Medical Field 4730 4.1. Types of Silver-Containing Biomaterials 4731 4.1.1. Metallic Silver Coatings and Silver's Antimicrobial Efficiency 4731 4.1.2. Silver-Containing Nanocomposites 4732 4.1.3. Silver-Containing Polymers 4732 4.1.4. Surface Modification with Ionic Silver Compounds 4734 4.1.5. Hybrid Silver Materials − Synergistic Effects 4734 4.2. Deposition Processes 4735 4.3. Mechanical Properties 4736 5. Biocompatibility of Silver 4737 5.1. General Routes of Silver Exposure 4737 5.2. Exposure to Silver-Containing Medical Products 4737 5.2.1. Dermal Contact: Burn Wound Dressings 4737 5.2.2. Bone Contact: Orthopedic and Dental Implants and Bone-Filling Products 4738 5.2.3. Blood Contact: Implants Introduced into the Vascular System 4739 5.3. Effects of Silver Exposure on Tissues and Organs 4739 5.3.1. Acute and Chronic Toxicity of Silver 4740 5.3.2. Tissue and Organ Damages 4740 5.3.3. Cellular Uptake of Silver 4741 5.4. Toxic Effects of Silver Nanoparticles 4741 5.5. Silver Detoxification 4742 5.5.1. Sequestration of Silver Ions 4742 5.5.2. Silver Ion Transport by ATPase P-type Efflux Pumps 4743 6. Conflicting Evidence 4744 7. Conclusions 4744 Author Information 4744 Corresponding Author 4744 Notes 4744 Biographies 4745 Acknowledgments 4746 References 4746

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Section: Mechanical Propertiesmentioning

confidence: 99%

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

et al. 2013

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“…Due to their antibacterial activity, silver-nanoparticles (NPs) are used commonly in medical products and devices, food storage materials, cosmetics, various health care products, and industrial products. In medical applications, silver-NPs have been used for silver-based dressings [1,2], silver-coated catheters [3,4], silver-based hydrogel [5-7]. Silver-NP-hydrogel composites are composed of silver-NP and hydrogel which are used as carrier for silver particles.…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel

Takemura

et al. 2012

Journal of Nanobiotechnology

118

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BackgroundSince silver-nanoparticles (NPs) possess an antibacterial activity, they were commonly used in medical products and devices, food storage materials, cosmetics, various health care products, and industrial products. Various silver-NP based medical devices are available for clinical uses, such as silver-NP based dressing and silver-NP based hydrogel (silver-NP-hydrogel) for medical applications. Although the previous data have suggested silver-NPs induced toxicity in vivo and in vitro, there is lack information about the mechanisms of biological response and potential toxicity of silver-NP-hydrogel.MethodsIn this study, the genotoxicity of silver-NP-hydrogel was assayed using cytokinesis-block micronucleus (CBMN). The molecular response was studied using DNA microarray and GO pathway analysis.Results and discussionThe results of global gene expression analysis in HeLa cells showed that thousands of genes were up- or down-regulated at 48 h of silver-NP-hydrogel exposure. Further GO pathway analysis suggested that fourteen theoretical activating signaling pathways were attributed to up-regulated genes; and three signal pathways were attributed to down-regulated genes. It was discussed that the cells protect themselves against silver NP-mediated toxicity through up-regulating metallothionein genes and anti-oxidative stress genes. The changes in DNA damage, apoptosis and mitosis pathway were closely related to silver-NP-induced cytotoxicity and chromosome damage. The down-regulation of CDC14A via mitosis pathway might play a role in potential genotoxicity induced by silver-NPs.ConclusionsThe silver-NP-hydrogel induced micronuclei formation in cellular level and broad spectrum molecular responses in gene expression level. The results of signal pathway analysis suggested that the balances between anti-ROS response and DNA damage, chromosome instability, mitosis inhibition might play important roles in silver-NP induced toxicity. The inflammatory factors were likely involved in silver-NP-hydrogel complex-induced toxic effects via JAK-STAT signal transduction pathway and immune response pathway. These biological responses eventually decide the future of the cells, survival or apoptosis.

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“…Kim et al [14] studied the water resistance of the nanofiber web, obtained by electrospinning, based on the hybrid system poly(vinyl alcohol) (PVA)/ POSS, made by incorporating silsesquioxane molecules onto hydrophilic PVA backbone. More recently, Wu et al [15] reported on the preparation of nanostructured fibrous hydrogel scaffolds of POSS-poly(ethylene glycol) hybrid thermoplastic polyurethanes incorporating Ag for antimicrobial applications. In particular, POSS nanocrystals, resulting from microphase separation, served as physical cross-linking points within the inorganic/organic hybrid network.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning: A Novel Method to Incorporate POSS Into a Polymer Matrix

Cozza

Monticelli

Marsano

2010

Macro Materials & Eng

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The effectiveness of electrospinning as a simple approach to disperse POSS into a polymer matrix at a nm‐level has been assessed. Electrospun and cast films were prepared by dissolving CA and epoxycyclohexylisobutyl POSS in the solvent mixture acetone/DMAc. The membranes were characterized by SEM, TEM and WAXD. Whereas films produced by casting showed µm‐sized POSS crystals, thus suggesting a small affinity between the polymer matrix and the POSS molecules, those prepared by electrospinning were characterized by a nanometric POSS distribution. This is explained by considering the peculiar solvent evaporation mechanism, occurring during the electrospinning process, which allows to produce nanofibers characterized by a silsesquioxane dispersion similar to that present in solution.magnified image

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Antimicrobial Properties of Nanostructured Hydrogel Webs Containing Silver

Cited by 102 publications

References 48 publications

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel

Electrospinning: A Novel Method to Incorporate POSS Into a Polymer Matrix

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