Antimicrobial properties of highly fluorinated silver(I) tris(pyrazolyl)borates

Dias, H. V. Rasika; Batdorf, Keith H.; Fianchini, Mauro; Diyabalanage, Himashinie V. K.; Carnahan, Sean; Mulcahy, Ryan; Rabiee, Amir; Nelson, Kevin D.; Waasbergen, Lorraine G. van

doi:10.1016/j.jinorgbio.2005.10.003

Cited by 62 publications

(39 citation statements)

References 30 publications

(33 reference statements)

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“…[11][12][13] In particular, silver and silver-based compounds are well known to be antiseptic to a spectrum of bacteria. [ 14 ] Recent studies have revealed that AgNPs possess high antibacterial activity with minimal perturbation to human cells, [15][16][17][18] which can lead to a range of medical and environmental applications. [ 19 ] While the detailed mechanisms have not been resolved, recent investigations have suggested that the AgNP-induced collapse of the bacterial membrane was responsible for such activity.…”

Section: Doi: 101002/adma201001934mentioning

confidence: 99%

Long‐Term Antimicrobial Effect of Silicon Nanowires Decorated with Silver Nanoparticles

et al. 2010

Advanced Materials

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Section: Doi: 101002/adma201001934mentioning

confidence: 99%

Long‐Term Antimicrobial Effect of Silicon Nanowires Decorated with Silver Nanoparticles

et al. 2010

Advanced Materials

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“…They have been recognized as excellent antimicrobial agents because of their effective biocide ability and nontoxicity to human cells [2][3][4][5][6]. According to Bonde et al [7] the activity of standard antibiotics was significantly increased in the presence of silver nanoparticles and that can be used effectively against antibiotic-resistant pathogens.…”

Section: Introductionmentioning

confidence: 99%

Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Mavrodinova

Popova

Yoncheva

et al. 2015

Journal of Colloid and Interface Science

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by Solid-state Ion Exchange (SSIE) procedure over zeolite Y, followed by deposition of sulfadiazine (SD) by dry mixing was examined for the preparation of topical antibacterial formulations. The ion-exchange and adsorptive properties of the zeolite matrix were utilized for the bactericidal Ag deposition and loading of antibiotic sulfadiazine.Experiments: Assessment of the encapsulation efficiency of both active components loaded by solid and liquid deposition methods was made by X-ray diffraction, TEM, FT-IR spectroscopy and thermogravimetric analysis (TGA). SD release kinetics was also determined.Findings: Sustained delivery of sulfadiazine has been observed from the Ag-modified zeolites compared to the parent HY material. It was found that if SD was loaded in solution, part of the zeolite silver ions was released and interacted with SD, forming AgSD. By solid-state SD deposition, the reaction between the drug and the silver was restricted within the limits of inter-atomic interaction, and total but prolonged drug release occurred.

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“…Silver compounds are generally known to have antimicrobial properties and exert their activities through interaction with DNA, reacting with thiol groups in proteins and interfering with electron transport (Russell and Hugo 1994). The highly fluorinated tris(pyrazolyl)borate silver complexes, [HB(3,5-(CF 3 ) 2 pz) 3 ]Ag(OSMe 2 )] (52) and [HB(3,5-(CF 3 ) 2 pz) 3 ] Ag(thf)] (53) were reported by Dias et al (2006) to show activities against Staphylococcus aureas with minimum inhibitory concentrations of approximately six times less than the reference compound Ag(I) sulfadiazine (16 lg/ml). The authors postulated that the activities are due to the ability of HB(3,5-(CF 3 ) 2 pz) 3 to make bioavailability of silver ions optimal.…”

Section: Antiparasites and Antibacterialsmentioning

confidence: 99%

Perspective: the potential of pyrazole-based compounds in medicine

2011

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Pyrazoles are widely used as core motifs for a large number of compounds for various applications such as catalysis, agro-chemicals, building blocks of other compounds and in medicine. The attractiveness of pyrazole and its derivatives is their versatility that allows for synthesis of a series of analogues with different moieties in them, thus affecting the electronics and by extension the properties of the resultant compounds. In medicine pyrazole is found as a pharmacophore in some of the active biological molecules. While pyrazole derivatives have been extensively studied for many applications including anticancer, antimicrobial, anti-inflammatory, antiglycemic, anti-allergy and antiviral, much less has been reported on their metal counterparts in spite of the fact that metals have been shown to impart activity to ligands. Thus this perspective is intended to demonstrate the potential of pyrazole and pyrazolyl metal complexes in the areas of drug discovery and development. Several examples, that include palladium, platinum, copper, gold, zinc, cobalt, nickel, iron, copper, silver and gallium complexes, are used to bolster the above point. For the purposes of this review three areas are discussed, that is pyrazole metal complexes as: (i) anticancer, (ii) antibacterial/parasitic and (iii) antiviral agents.

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Antimicrobial properties of highly fluorinated silver(I) tris(pyrazolyl)borates

Cited by 62 publications

References 30 publications

Long‐Term Antimicrobial Effect of Silicon Nanowires Decorated with Silver Nanoparticles

Long‐Term Antimicrobial Effect of Silicon Nanowires Decorated with Silver Nanoparticles

Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Perspective: the potential of pyrazole-based compounds in medicine

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