Antimicrobial properties of extracts and compounds isolated from &lt;i&gt;Berberis jaeschkeana&lt;/i&gt;

Alamzeb, Muhammad; Khan, Muhammad Rafiullah; Ali, Saqib; Shah, Syed Qaiser; Rashid, Mehboob ur

doi:10.3329/bjp.v8i2.13551

Cited by 18 publications

(11 citation statements)

References 6 publications

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“…It is clear from Table 2 that constituents of B. petiolaris extracts belong to different classes of alkaloids, flavanoids and acids, as reported in the literature. [2,20,21] Protoberberine alkaloids…”

Section: Qualitative Analysismentioning

confidence: 99%

Rapid profiling and structural characterization of bioactive compounds and their distribution in different parts ofBerberis petiolarisWall. ex G. Don applying hyphenated mass spectrometric techniques

Singh

Bajpai

Srivastava

et al. 2014

Rapid Commun. Mass Spectrom.

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Rapid and accurate HPLC/ESI-QTOF-MS/MS and UPLC/ESI-QqLIT-MS/MS methods were established for identification, characterization and quantification of phytochemicals in the ethanolic extract of Berberis petiolaris. These methods, therefore, can be used for studies on phytochemical variation in different parts of the plant. Principle components analysis (PCA) may be used for plant part discrimination.

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Section: Qualitative Analysismentioning

confidence: 99%

Rapid profiling and structural characterization of bioactive compounds and their distribution in different parts ofBerberis petiolarisWall. ex G. Don applying hyphenated mass spectrometric techniques

Singh

Bajpai

Srivastava

et al. 2014

Rapid Commun. Mass Spectrom.

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“…The genus Berberis is known to possess isoquinoline, bisbenzylisoquinoline, protoberberine, aphorphine, benzyl isoquinoline, and protopine alkaloids [ 2 ]. The phytochemical screening of the crude extracts of Berberis species have revealed the presence of alkaloids, flavonoids, steroids, glycosides, terpenoids, reducing sugars, and saponins [ 3 ]. Recent pharmacological studies have established diverse pharmacological properties for different members of the genus Berberis including antimicrobial, antinociceptive, anti-inflammatory, antihistaminic, anticholinergic, vasodilatory, antipyretic, antibacterial, antifungal, antirheumatic, and alleviating urinary and gastrointestinal discomforts.…”

Section: Introductionmentioning

confidence: 99%

NMR, Novel Pharmacological and In Silico Docking Studies of Oxyacanthine and Tetrandrine: Bisbenzylisoquinoline Alkaloids Isolated fromBerberis glaucocarpaRoots

Alamzeb

Omer

Ur-Rashid

et al. 2018

Journal of Analytical Methods in Chemistry

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Urease enzyme is responsible for gastric cancer, peptic ulcer, hepatic coma, and urinary stones in millions of people across the world. So, there is a strong need to develop new and safe antiurease drugs, particularly from natural sources. In search for new and effective drugs from natural sources bioassay-guided fractionation and isolation of Berberis glaucocarpa Stapf roots bark resulted in the isolation and characterization, on the basis of 1D and 2D NMR data, of two bisbenzylisoquinoline alkaloids, oxyacanthine (1) and tetrandrine (2), followed by urease inhibition studies. Crude extract, all the subfractions and the isolated compounds 1 and 2 displayed excellent urease enzyme inhibition properties in vitro. The antiurease nature and possible mode of action for compounds 1 and 2 were verified and explained through their molecular docking studies against jack-bean urease enzyme. Half-maximum inhibitory concentration (IC50) was calculated for compounds 1 and 2. The IC50 value was found to be 6.35 and 5.51 µg/mL for compounds 1 and 2, respectively. Both compounds 1 and 2 have minimal cytotoxicity against THP-1 monocytic cells.

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“…The major phytochemical studies have been conducted on Asian species, such as Berberis jaeschkeana, Berberis asiatica, Berberis aristata, and Berberis lyceum. These species showed a relatively high content of tannins, saponins, alkaloids, flavonoids, steroids, phenolic compounds, and carbohydrates [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents of the Root of Berberis Microphylla

Furrianca

Alvear

Zambrano

et al. 2017

Asian J Pharm Clin Res

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Objective: To objective of this work was to perform phytochemical qualitative and quantitative analyzes of the main secondary metabolites in the root of Berberis microphylla. Methods:The extracts of B. microphylla root were tested through phytochemical screening and the quantification of the most important constituents was carried out using spectrophotometric and gravimetric techniques.Results: Phytochemical screening of both extracts showed the presence of alkaloids, flavonoids, glycosides, cardiac glycosides, saponins, terpenes, and tannins, which are pharmacologically important. Quantification of the major phytochemicals groups showed that the ethanolic extract contains 3.9% alkaloids, 0.46% flavonoids, 9.53% tannins, and 3.60% saponins. Similarly, the methanolic extract contains 6.61% alkaloids, 0.41% flavonoids, 7.40% tannins, and 1.43% saponins. Conclusion:This is the first time that the presence of tannins, flavonoids, and saponins in this plant has been reported. The medicinal properties of the root of B. microphylla may exist due to the presence secondary metabolites.

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Antimicrobial properties of extracts and compounds isolated from <i>Berberis jaeschkeana</i>

Cited by 18 publications

References 6 publications

Rapid profiling and structural characterization of bioactive compounds and their distribution in different parts ofBerberis petiolarisWall. ex G. Don applying hyphenated mass spectrometric techniques

Rapid profiling and structural characterization of bioactive compounds and their distribution in different parts ofBerberis petiolarisWall. ex G. Don applying hyphenated mass spectrometric techniques

NMR, Novel Pharmacological and In Silico Docking Studies of Oxyacanthine and Tetrandrine: Bisbenzylisoquinoline Alkaloids Isolated fromBerberis glaucocarpaRoots

Phytochemical Constituents of the Root of Berberis Microphylla

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