Antimicrobial Properties of Extracellular Matrix Scaffolds for Tissue Engineering

Jiménez-Gastélum, German; Aguilar-Medina, Elsa Maribel; Soto-Sáinz, Eduardo; Ramos‐Payán, Rosalío; Silva-Benítez, Erika de Lourdes

doi:10.1155/2019/9641456

Cited by 21 publications

(21 citation statements)

References 82 publications

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“…Also, ECM‐based scaffolds from different tissues and organs regulate surgical infections because of their antimicrobial activity against microorganisms, which can enhance clinical prognosis. Despite these benefits, lots of work still need to be done to investigate other pathogens beyond bacteria 92 …”

Section: Antimicrobial Strategiesmentioning

confidence: 99%

Collagen‐based biomaterials for biomedical applications

et al. 2021

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Collagen is an insoluble fibrous protein that composes the extracellular matrix in animals. Although collagen has been used as a biomaterial since 1881, the properties and the complex structure of collagen are still extensive study subjects worldwide. In this article, several topics of importance for understanding collagen research are reviewed starting from its historical milestones, followed by the description of the collagen superfamily and its complex structures, with a focus on type I collagen. Subsequently, some of the superior properties of collagen‐based biomaterials, such as biocompatibility, biodegradability, mechanical properties, and cell activities, are pinpointed. These properties make collagen applicable in biomedicine, such as wound healing, tissue engineering, surface coating of medical devices, and skin supplementation. Moreover, some antimicrobial strategies and the general host tissue responses regarding collagen as a biomaterial are presented. Finally, the current status and clinical application of the three‐dimensional (3D) printing techniques for the fabrication of collagen‐based scaffolds and the reconstruction of the human heart's constituents, such as capillary structures or even the entire organ, are discussed. Besides, an overall outlook for the future of this unique biomaterial is provided.

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Section: Antimicrobial Strategiesmentioning

confidence: 99%

Collagen‐based biomaterials for biomedical applications

et al. 2021

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“…These extracellular vesicles were found to be associated with favorable properties including enhanced angiogenic potential, stem cell recruitment and modulation of macrophage phenotype ( Hussey et al, 2019 ; Quijano et al, 2020 ). Furthermore, the presence of antimicrobial peptides within injectable decellularized ECM scaffolds has been documented and might play a significant role in future studies in the field of regenerative endodontics ( Jimenez-Gastelum et al, 2019 ; Wei et al, 2021 ).…”

Section: Alternative “Biomimetic” Strategies Could Decrease Cytotoxic...mentioning

confidence: 99%

Regenerative Endodontics and Minimally Invasive Dentistry: Intertwining Paths Crossing Over Into Clinical Translation

Elnawam

Abdelmougod

Mobarak

et al. 2022

Front. Bioeng. Biotechnol.

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Regenerative endodontic procedures have been described for over a decade as a paradigm shift in the treatment of immature necrotic permanent teeth, owing to their ability to allow root maturation with subsequent enhancement of the tooth’s fracture resistance in addition to the potential for regeneration of vital intracanal tissues. Concomitantly, minimally invasive endodontics is another rising concept with the main concern of preservation of tooth structure. Stemming from their potential to preserve the original tooth structure, both regenerative and minimally invasive endodontics could be considered as two revolutionary sciences with one common goal. Achieving this goal would entail not only employing the appropriate strategies to recreate the ideal regenerative niche but modifying existing concepts and protocols currently being implemented in regenerative endodontics to address two important challenges affecting the outcome of these procedures; conservation of tooth structure and achieving effective disinfection. Therefore, the search for new biomimetic cell-friendly disinfecting agents and strategies is crucial if such a novel integratory concept is to be foreseen in the future. This could be attainable by advocating a new merged concept of “minimally invasive regenerative endodontic procedures (MIREPs),” through modifying the clinical protocol of REPs by incorporating a minimally invasive access cavity design/preparation and biomimetic disinfection protocol, which could enhance clinical treatment outcomes and in the future; allow for personalized disinfection/regeneration protocols to further optimize the outcomes of MIREPs. In this review, we aim to introduce this new concept, its realization and challenges along with future perspectives for clinical implementation.

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“…Lastly, an indirect immunomodulatory effect of the ECM is given by its anti-microbial function. Indeed, many ECM components contains highly positively charged or hydrophobic peptides that are able to permeate bacteria membranes and kill them [ 197 ]. ECM-derived anti-microbial peptides (AMPs) are often released upon ECM degradation during inflammation.…”

Section: Ecm-mediated Tumor Immunomodulationmentioning

confidence: 99%

“…The sensitivity of bacteria to specific AMPs depends on the composition of the bacteria cell wall. For example, E. faecalis , E. coli and P. aeruginosa are sensitive to the AMPs released from laminin, fibronectin and vitronectin [ 197 ]. In cancer, AMPs are often considered to be anti-tumor agents due to some direct cytotoxic actions on cancer cells or by enhancing tumor inflammation.…”

Section: Ecm-mediated Tumor Immunomodulationmentioning

confidence: 99%

Molecular Mechanisms of Tumor Immunomodulation in the Microenvironment of Colorectal Cancer

Plundrich

Chikhladze

Fichtner‐Feigl

et al. 2022

IJMS

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Colorectal cancer remains one of the most important health challenges in our society. The development of cancer immunotherapies has fostered the need to better understand the anti-tumor immune mechanisms at play in the tumor microenvironment and the strategies by which the tumor escapes them. In this review, we provide an overview of the molecular interactions that regulate tumor inflammation. We particularly discuss immunomodulatory cell-cell interactions, cell-soluble factor interactions, cell-extracellular matrix interactions and cell-microbiome interactions. While doing so, we highlight relevant examples of tumor immunomodulation in colorectal cancer.

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Antimicrobial Properties of Extracellular Matrix Scaffolds for Tissue Engineering

Cited by 21 publications

References 82 publications

Collagen‐based biomaterials for biomedical applications

Collagen‐based biomaterials for biomedical applications

Regenerative Endodontics and Minimally Invasive Dentistry: Intertwining Paths Crossing Over Into Clinical Translation

Molecular Mechanisms of Tumor Immunomodulation in the Microenvironment of Colorectal Cancer

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