Antimicrobial properties of delmopinol against oral bacteria

Abstract

Antimicrobial properties of the morpholine derivative delmopinol hydrochloride were investigated in vitro. Minimum inhibitory concentrations were measured for a range of oral bacteria by broth and agar dilution techniques and minimum bactericidal concentrations were measured in broth. The rate of kill was investigated by determination and analysis of kill curves. The results indicated that delmopinol is a relatively weak antimicrobial in comparison with chlorhexidine. However, it may selectively affect certain species of oral bacteria which are of importance in plaque formation.

Delmopinol – adsorption to and absorption through the oral mucosa

“…In contrast to other products on the market delmopinol has comparably low antibacterial properties that should not disrupt the natural balance of the oral microbiota. Instead preclinical studies have suggested that one important aspect for the efficacy of delmopinol is that the compound counteracts new plaque formation by interfering with enzymes responsible for the synthesis of polysaccharides important for plaque matrix formation and stability [1][2][3][4][5].…”