Antimicrobial Properties of Alkyl-2-Cyanoacrylate Tissue Adhesives in Vitro

Bacteremia after endoscopic injection of N-butyl-2-cyanoacrylate for gastric variceal bleeding

“…Some investigators claim that cyanoacrylate has in vitro antibacterial properties. 11,12 Therefore, our theory was that cyanoacry-late injection might limit bacterial invasion and reduce the frequency of bacteremia. To test the hypothesis, this study was designed to compare the frequency of bacteremia after endoscopic injection of cyanoacrylate for gastric variceal bleeding with that after upper endoscopy for nonvariceal bleeding in patients with cirrhosis.…”

Advanced Use of Tissue Adhesive in Hair Transplantation

“…Cyanoacrylates are inherently bactericidal 16,17 . We encounter graft infection rarely (< 1/20,000 grafts).…”

Recurrent Bacteremia, a Complication of Cyanoacrylate Injection for Variceal Bleeding: Report of Two Cases and Review of the Literature

“…In all cases, consequences would be an infected N-butyl-2-cyanoacrylate conglomerate localized in the varices associated with an anatomic path between the gastrointestinal lumen and the vascular spaces [2]. In contrast to traditional sclerosing agents, cyanoacrylate has been recognized to have an in vitro antimicrobial effect against Gram-positive and Gram-negative bacteria [7, 8]. This finding was however never confirmed in vivo underlining the balance between a potential antimicrobial effect and the fact that cyanoacrylate is a foreign material and may, thereby, provide an ideal route for bacterial invasion.…”