Antimicrobial profiles of periodontal pathogens isolated from periodontitis patients in the Netherlands and Spain

Abstract

Differences exist in the susceptibility profiles of periodontal pathogens isolated from periodontitis patients in Spain and in The Netherlands. This implicates that antibiotic susceptibility testing is necessary to determine efficacy of antimicrobial agents. Also, clinical studies with antibiotics should take these differences into account. The information from the present study indicates that it may not be possible to develop uniform protocols for usage of antibiotics in the treatment of severe periodontitis in the European Union.

High resistance against clindamycin, metronidazole and amoxicillin in Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans isolates of periodontal disease

“…The adjunctive use of systemically administered antibiotics has been shown to provide a better clinical outcome, particularly in terms of pocket depth reduction and attachment-level gain, than scaling and root planing in chronic periodontitis subjects (6,7). Commonly used antibiotics include clindamycin, metronidazole and amoxicillin (6,8). Besides, positive responses have been reported with amoxicillin/clavulanic (6,8) and moxifloxacin (7) in the treatment of periodontitis.…”

“…Commonly used antibiotics include clindamycin, metronidazole and amoxicillin (6,8). Besides, positive responses have been reported with amoxicillin/clavulanic (6,8) and moxifloxacin (7) in the treatment of periodontitis. Most of the knowledge available on the microbial composition of subgingival plaque is based on studies from the United States and Europe (8)(9)(10), where therapeutic oral care programs are available to significant portions of the population.…”

“…Besides, positive responses have been reported with amoxicillin/clavulanic (6,8) and moxifloxacin (7) in the treatment of periodontitis. Most of the knowledge available on the microbial composition of subgingival plaque is based on studies from the United States and Europe (8)(9)(10), where therapeutic oral care programs are available to significant portions of the population. Temporal and geographic changes in antibiotic susceptibility among anaerobes have been reported in Europe (8,10).…”

Efecto de las enterobacterias en pacientes con periodontitis crónica

“…Los antibióticos que tradicionalmente se han utilizado como coadyuvantes a la terapia mecánica y que han demostrado efectividad clínica y microbiológica son: amoxicilina, amoxicilina/clavulánico tetraciclinas, metronidazol y azitromicina (5,20,(44)(45)(46)(47). Sin embargo, teniendo en cuenta que en algunas regiones se ha reportado la presencia de enterobacterias en placa subgingival en pacientes con periodontitis crónica, la respuesta al tratamiento puede ser deficiente.…”

“…Como ya se mencionó, la periodontitis crónica es una enfermedad infecciosa y se ha documentado extensamente el papel de la microflora subgingival en su etiología (4,5). Diferentes estudios han demostrado similitudes en los periodontopatógenos y han encontrado que en los pacientes con periodontitis crónica, están presentes y en forma conjunta, la mayoría de los siguientes microorganismos: Porphyromona gingivalis, Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Eikenella corrodens, Campylobacter rectus, Peptoestreptococo micros, Treponema denticola y la Prevotella intermedius (6,7).…”