Antimicrobial profile of Acinetobacter baumannii at a tertiary hospital in Honduras: a cross-sectional analysis

Abstract

Acinetobacter baumannii is considered to be a worldwide threat to public health due to its high antimicrobial resistance rates and the severe infections it can cause. Little is known about this pathogen’s resistance in Central America. This report aims to describe the antimicrobial resistance profile of A. baumannii at a tertiary hospital in Honduras. The cross-sectional analysis was conducted at the tertiary care laboratory hospital in San Pedro Sula in 2015 – 2017. A total of 113 consecutive microbiological reports were analyzed, comprising 100 individuals from whom A. baumannii was isolated. Epidemiological and microbiological data, including the isolation setting and patient information, were recorded. Prevalence of multi-drug and extensive-drug resistance was assessed according to international standards. The median age of individuals was 22 years (2 – 35 years); female was the predominant gender (53%). The hospital’s pediatric wards had the highest number of isolates (n = 48). The most frequent specimen from which A. baumannii was isolated was skin and soft tissue (n = 39). Resistance to carbapenems was reported to be 40.7% among the isolates (n = 46); multi-drug resistant, 35.4% (n = 40); and extensively-drug resistant, 7.1% (n = 8). This report reveals the threat of this pathogen to public health in Honduras and appeals for antibiotic stewardship programs throughout Central America.

Health vigilance concerning Acinetobacter baumannii bacteremia at the mohammed VI university hospital of oujda (morocco): epidemiological profile and antibiotic resistance

“…The resistance to ciprofloxacin in the different studies is higher than 50% which is in line with the data of our study [23][24][25][26][27][28].…”

First Detection of Acinetobacter baumannii in Pediculus humanus capitis from Latin America

“…In the countries where lice were collected, reports of A. baumannii infections are almost exclusively healthcare-associated. For example, in Honduras, a cross-sectional study conducted at a tertiary health care centre reported that the majority of isolates were from patients in the intensive care unit (ICU), with a significant proportion (44%) hospitalized in the pediatric wards (neonatal ICU and general pediatrics) [ 36 ]. In Argentina, carbapenem resistance in A. baumannii has been monitored since the year 2000, and Argentina is the Latin American country with the most scientific reports on this infection [ 37 ].…”

Antibacterial activity of Mangifera indica seed extracts combined with common antibiotics against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii isolates

“…It is worth mentioning that both of these bacteria are among ESKAPE organisms (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter) (Zuniga-Moya et al 2020) and significant nosocomial pathogens (Zavascki et al 2010). Furthermore, the problem of drug resistance in P. aeruginosa and A. baumannii limits their treatment of infections.…”