Antimicrobial potentiality ofPhyllanthus amarusagainst drug resistant pathogens

Abstract

The antimicrobial potentiality of the methanolic extract of Phyllanthus amarus (Family: Euphorbiaceae) was studied against some drug resistant pathogenic bacterial strains by disc diffusion and agar dilution method. The extract showed significant concentration-dependent antibacterial activity particularly against gram-negative microbes. The study illustrated the claim of the usefulness of the plant in dysenteric and diarrheal infections and also suggested its use in fever. The antibacterial action was mainly due to the isolated phyllanthin.

Antibacterial activity of selected medicinal plants used in South-western Ethiopia

“…Likewise, most of the isolates had MBC values of 16.6 mg/mL with the exception of 50 mg/mL of all the extracts against E. coli. Usually, plant extracts are bacteriostatic at relatively lower concentrations and bactericidal at higher concentrations (Jaya et al, 2008) although antibacterial activities could depend on the actual concentration of active compounds in the crude extract (Mazumder et al, 2006). In contrary to the current observation, the MIC values of extracts of two other species Raninculus (R. marginatus var.…”

Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review

“…The extract was found to be moderately active against S. typhimurium, P. aeruginosa, B. subtilis, and other pneumonia causing strains of Klebsiella and Streptococcus spp. The antibacterial action was mainly due to the isolated phyllanthin (Mazumder et al, 2006). The ethanolic extracts of nine Peruvian medicinal plants including P. amarus were screened for antimicrobial activity against Bacillus cereus ATCC 11,778, B. subtilis (Kloucek et al, 2005).…”

Antioxidant activity of some polyphenol constituents of the medicinal plantPhyllanthus amarusLinn

“…1 Phyllanthus amarus Linn is a widely distributed tropical medicinal plant, with many reported beneficial effects. These include antiviral, 2 antiinflammatory, 3,4 hypoglycaemic, hypocholesteromic, 5 antibacterial, 6 and radioprotective activities. 7 While there is only a single report 8 demonstrating antioxidant activities of Phyllanthus extracts individual compounds purified from this plant have never been examined in detail for their antioxidant activity.…”