Antimicrobial Potential of <i>Rosmarinus officinalis</i> Commercial Essential Oil in the Treatment of Vaginal Infections in Pregnant Women

Bogavac, Mirjana; Karaman, Maja; Suđi, Jan; Radovanović, Bojan B; Janjušević, Ljiljana; Ćetković, Nenad; Tešanović, Kristina

doi:10.1177/1934578x1701200136

Cited by 11 publications

(11 citation statements)

References 29 publications

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“…Artemia spp. (brine shrimps) have also been used as a biological model in three research papers [ 39 , 40 , 69 ], however, they are only suitable for ecotoxicity studies [ 136 ].…”

Section: Cytotoxicitymentioning

confidence: 99%

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

et al. 2020

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Extensive documentation is available on plant essential oils as a potential source of antimicrobials, including natural drugs against Candida spp. Yeasts of the genus Candida are responsible for various clinical manifestations, from mucocutaneous overgrowth to bloodstream infections, whose incidence and mortality rates are increasing because of the expanding population of immunocompromised patients. In the last decade, although C. albicans is still regarded as the most common species, epidemiological data reveal that the global distribution of Candida spp. has changed, and non-albicans species of Candida are being increasingly isolated worldwide. The present study aimed to review the anti-Candida activity of essential oils collected from 100 species of the Lamiaceae family growing in the Mediterranean area and the Middle East. An overview is given on the most promising essential oils and constituents inhibiting Candida spp. growth, with a particular focus for those natural products able to reduce the expression of virulence factors, such as yeast-hyphal transition and biofilm formation. Based on current knowledge on members of the Lamiaceae family, future recommendations to strengthen the value of these essential oils as antimicrobial agents include pathogen selection, with an extension towards the new emerging Candida spp. and toxicological screening, as it cannot be taken for granted that plant-derived products are void of potential toxic and/or carcinogenic properties.

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“…Artemia spp. (brine shrimps) have also been used as a biological model in three research papers [ 39 , 40 , 69 ], however, they are only suitable for ecotoxicity studies [ 136 ].…”

Section: Cytotoxicitymentioning

confidence: 99%

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

et al. 2020

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“…Nomenclature of volatile compounds (variables): α-pinene, V1; camphene, V2; α-pinene, V3; α-phellandrene, V5; Δ3-carene, V6; α-terpinene, V7; 1,8-cineole, V8; γ-terpinene, V9; trans-sabinene hydrate, V10, α-terpinolene, V11; linalool, V12; campholenal, V13; trans-pinocarveol, V15; borneol, V16; terpinen-4-ol, V17; α-terpineol, V18; verbenone, V19; iso-borneol, V20; cis-carveol, V21; bornyl acetate, V23; α-citronellol, V24. Samples are listed according to the code reported in Table 1 (RPC, RCC, and RMD1, 2, and 3) and the months of collections (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Statistical Analysis and Principal Component Analysismentioning

confidence: 99%

“…1 The interest on this species is associated with the multiple uses of the plant: as aromatic plant, it is well appreciated for the culinary quality of its leaves; as shrub, it is useful as ornamental plant in garden; finally, the high production of phenol biological compounds and EOs made rosemary the most used medicinal and aromatic plant worldwide. 2 Antibacterial, [3][4][5] antifungal, 6,7 anticancer, 8,9 and antioxidant [10][11][12][13] proprieties have been found in the EO extracted from its leaves. The production of secondary metabolites is affected, as in many other plants, 14 by environmental conditions; in literature are reported examples of the variability of both polar fraction 15 and volatile organic compounds.…”

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confidence: 99%

Seasonal Variation of Essential Oil in Rosmarinus officinalis Leaves in Sardinia

Melito

Petretto

Chahine

et al. 2019

Natural Product Communications

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Rosmarinus officinalis L. is an aromatic plant belonging to the Lamiaceae family widely distributed in the Mediterranean area. The interest on this species is related to the multiple uses of the plant as a food ingredient, in the pharmaceutical and cosmetic industries. The chemical composition of essential oil (EO) from 5 accessions of R. officinalis L., collected monthly through a full year in Sardinia, has been studied by gas chromatography (GC) and GC-mass spectrometry technique. The EO ranged from 0.29% to 0.89%. The qualitative determinations revealed the presence of 27 compounds belonging to 6 chemical groups (hydrocarbon monoterpene, alcohols, aldehydes, ketones, esters, hydrocarbon sesquiterpene). Overall the GC-flame ionization detector analysis showed the presence of 7 major compounds: α-pinene (26%-28%), camphene (5%-8%), 1,8-cineole (15%-25%), borneol (5%-11%), camphor (3%-12%), verbenone (6%-15%), and bornyl acetate (4%-7%). Chromatographic data were also subjected to a chemometric approach that evidenced discrimination of the samples according to the site of collection.

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“…EOs are widely used as a possible alternative therapy for their antimicrobial effects [ 31 , 32 ]. The screening of medical plants, and in particular of those rich in EOs, for antibacterial and antifungal activities is important to find new active antimicrobial compounds.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition and In Vitro Antimicrobial Activity of Essential Oils from the Lamiaceae Family against Streptococcus agalactiae and Candida albicans Biofilms

et al. 2020

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The antimicrobial activity of different essential oils (EOs) from the Lamiaceae family was evaluated on Streptococcus agalactiae, Candida albicans, and lactobacilli. S. agalactiae is the main cause of severe neonatal infections, such as sepsis, meningitis, and pneumonia. C. albicans is a primary causative agent of vulvovaginal candidiasis, a multifactorial infectious disease of the lower female reproductive tract. Lactobacilli represent the dominant bacterial species of the vaginal flora and constitute the natural defense against pathogens. On the basis of the preliminary results, the attention was focused on the EOs from Lavandula x intermedia Emeric ex Loisel. and Mentha arvensis L. By using gas ghromatography (GS) retention data and mass spectra, it was possible to identify more than 90% of the total composition of the EO samples. The minimal inhibitory concentration (MIC) and anti-biofilm activity of the two EOs were determined against all isolated strains, using the EOs by themselves or in combination with each other and with drugs (erythromycin and fluconazole). The results showed a good antimicrobial and anti-biofilm activity of both EOs and a synergistic effect, leading to the best results against all the strains, resulted using the combinations EOs/EOs and antimicrobials/EOs.

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Antimicrobial Potential of Rosmarinus officinalis Commercial Essential Oil in the Treatment of Vaginal Infections in Pregnant Women

Cited by 11 publications

References 29 publications

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

Seasonal Variation of Essential Oil in Rosmarinus officinalis Leaves in Sardinia

Phytochemical Composition and In Vitro Antimicrobial Activity of Essential Oils from the Lamiaceae Family against Streptococcus agalactiae and Candida albicans Biofilms

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