Antimicrobial Photodynamic Therapy to treat chemotherapy-induced oral lesions: Report of three cases

Rocha, Breno Amaral; Filho, Mário Rodrigues Melo; Simões, Alyne

doi:10.1016/j.pdpdt.2015.07.172

Cited by 11 publications

(8 citation statements)

References 2 publications

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“…In 2016, (Rocha et al, 2016) a case-report described the treatment with photodynamic therapy (aPDT) in a 28 years-old diagnosed with acute lymphoblastic leukaemia suffering from AC at the right commissure. After the application of Methylene Blue 0.01% for five minutes, aPDT was performed with a continuous diode laser irradiation, 660 nm, with a dose of 120 J/cm 2 , 120s (one point), 4.8J, 40mW, 1W/cm 2 and spot size 0.04 cm 2 , leading to an immediate pain relief and reepithelization of the site.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Treatment of angular cheilitis: A narrative review and authors’ clinical experience

et al. 2019

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Section: Photodynamic Therapymentioning

confidence: 99%

Treatment of angular cheilitis: A narrative review and authors’ clinical experience

et al. 2019

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“…PDT has shown good effects in the treatment of various diseases, including psoriasis and atherosclerosis [28]. In addition, PDT has been shown to kill microbial cells and treat fungal, bacterial, and viral infections [29,30]. It has been shown to be effective in antiviral therapy, including HIV [31] and herpes [32].…”

Section: Application Of Pdtmentioning

confidence: 99%

Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy

Lin

Liu

Han

et al. 2021

IJMS

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Photodynamic therapy (PDT) is a promising therapy due to its efficiency and accuracy. The photosensitizer is delivered to the target lesion and locally activated. Viral nanoparticles (VNPs) have been explored as delivery vehicles for PDT in recent years because of their favorable properties, including simple manufacture and good safety profile. They have great potential as drug delivery carriers in medicine. Here, we review the development of PDT photosensitizers and discuss applications of VNP-mediated photodynamic therapies and the performance of VNPs in the treatment of tumor cells and antimicrobial therapy. Furthermore, future perspectives are discussed for further developing novel viral nanocarriers or improving existing viral vectors.

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Section: Introductionmentioning

confidence: 99%

“…Until date, four clinical cases and two clinical trials reporting the treatment of oral herpetic lesions in oncologic patients with APDT were published, which showed that the treatment was effective for herpetic oral lesions [14][15][16][17] . Current evidence points out that APDT may be an efficacy alternative for the treatment of herpetic oral and perioral lesions in immunocompetent and oncologic individuals 10,14,15 . However, the evidence for oncologic patients is still limited and to the best of the authors' knowledge, there is no clinical study on the efficacy of APDT for herpes simplex lesions comparing results for immunocompetent and oncologic individuals.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of photodynamic therapy for herpes simplex lesions in immunocompetent and oncologic individuals

Mello¹,

Mariani²,

Lisboa³

et al. 2022

JORDI

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Aims:To investigate the efficacy of antibacterial photodynamic therapy (APDT) for the treatment of herpes simplex oral and perioral lesions in immunocompetent and oncologic individuals. Methods and Results: APDT was applied in G1 (immunocompetent, n=26) and G3 (oncologic, n=6) with methylene blue 0.01% followed by 660ηm low level LASER in all the lesion area. In G2, immunocompetent patients received Acyclovir cream 50mg/g prescription. Lesion stage, size, edema, and pain degree were obtained at the beginning of the treatment (T0), after 24 hours (T1), 48 hours (T2), 72 hours (T3), and 7 days (T4).Intra-group analyses showed significant improvement in all criteria for G1 and G3 between T0 and T4 (p<0.05), while for G2 no differences were found in lesion stage and pain level between study times (p>0.05). Most of G1 individuals showed crust stage in T2 and T3, while most of G3 individuals presented papule or vesicle at the same times (p<0.05); and G2 presented higher scores of edema in T2 than G1 and G3 at the same time (p<0.05). Conclusions: It is possible to conclude that APDT is an effective adjuvant treatment for HSV oral and perioral infections in both immunocompetent and oncologic individuals.

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Antimicrobial Photodynamic Therapy to treat chemotherapy-induced oral lesions: Report of three cases

Cited by 11 publications

References 2 publications

Treatment of angular cheilitis: A narrative review and authors’ clinical experience

Treatment of angular cheilitis: A narrative review and authors’ clinical experience

Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy

The efficacy of photodynamic therapy for herpes simplex lesions in immunocompetent and oncologic individuals

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