Antimicrobial Photodynamic Therapy May Promote Periodontal Healing Through Multiple Mechanisms

Braham, Pam; Herron, Caroline; Street, Cale N.; Darveau, Richard P.

doi:10.1902/jop.2009.090214

Cited by 111 publications

(84 citation statements)

References 47 publications

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“…In other observations of PDT application, there was a remarkable reduction of lymphocytes in the irradiated tissues [51]. An inactivation of host destructive cytokines, which prevent periodontal tissue regeneration, is also an important outcome of this therapy [52]. In terms of antibacterial properties, it has been confirmed that topically applied toluidine blue and laser light are able to kill P.gingivalis from the gingival crevice without any damage of the adjacent tissues.…”

Section: Application Of Pdt In Periodontal Therapymentioning

confidence: 86%

Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases

Prażmo¹,

Kwaśny²,

Łapiński³

et al. 2016

Adv Clin Exp Med

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Section: Application Of Pdt In Periodontal Therapymentioning

confidence: 86%

Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases

Prażmo¹,

Kwaśny²,

Łapiński³

et al. 2016

Adv Clin Exp Med

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“…25 A plausible explanation for this improvement in the SRP + aPDT group patients could be bacterial load reduction and inactivation of bacterial virulence factors and cytokines when the photosensitizer dye is irradiated with laser. 26 Komerik et al successfully demonstrated killing of Porphyromonas gingivalis in the gingival crevices of rats without damaging the adjacent periodontal tissues. 27 In another study, Pinheiro et al showed a significantly greater reduction in the percentage of viable bacteria in periodontal pockets treated with aPDT (96%) compared to those treated with SRP alone (81%).…”

Section: Discussionmentioning

confidence: 99%

Effect of Antimicrobial Photodynamic Therapy as an Adjunct to Nonsurgical Treatment of Deep Periodontal Pockets: A Clinical Study

et al. 2016

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Introduction: Deep periodontal pockets pose a great challenge for nonsurgical periodontal treatment. Scaling and root planing (SRP) alone may not suffice in cases where surgical therapy cannot be undertaken. Various recent studies have suggested the use of antimicrobial Photodynamic Therapy (aPDT) for the management of periodontal infections. The aim of this study was to evaluate the effects of using aPDT along with SRP, compared to SRP alone for the management of deep periodontal pockets. Methods: Thirty patients with chronic periodontitis, who met the criteria of having periodontal pockets with depth ≥ 6 mm and bleeding on probing (BOP) in at least 2 different quadrants were included. After SRP, one quadrant was randomly selected for aPDT (test), while another served as control. Clinical parameters i.e. plaque index (PI), modified sulcular bleeding index (mSBI), probing depth (PD) and clinical attachment level (CAL) were measured at baseline, 1 month and 3 months post-treatment intervals. Results: All clinical parameters significantly improved in both groups after 1 and 3 months. At 1-month interval, inter-group difference in mean change was statistically significant (P < 0.05) in terms of mSBI (0.85 ± 0.41in test vs 0.54 ± 0.47 in control group) and PD (1.77±0.86 in test vs 1.3 ± 0.95 in control group). At 3 months interval, no statistically significant difference was observed between test and control groups except in terms of mSBI (0.97 ± 0.45 in test vs 0.73 ± 0.42 in control group). Conclusion: aPDT appears to play an additional role in reduction of gingival inflammation when used along with nonsurgical mechanical debridement of deep periodontal pockets.

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“…A single antimicrobial PDT treatment in vitro potently inactivated protease activity and resulted in a 4 log 10 reduction in the viability of P. gingivalis. 139 Dose and time-of-exposure experiments revealed that protease inactivation occurred at lower concentrations of PS and less time of light exposure. Also, antimicrobial PDT treatment has been shown to be potently and functionally inactivated IL-1β and TNFα.…”

Section: Biofilm Eradicationmentioning

confidence: 98%

“…Also, antimicrobial PDT treatment has been shown to be potently and functionally inactivated IL-1β and TNFα. 139 …”

Section: Biofilm Eradicationmentioning

confidence: 99%

All you need is light

et al. 2011

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Antimicrobial Photodynamic Therapy May Promote Periodontal Healing Through Multiple Mechanisms

Abstract: aPDT treatment may augment periodontal treatment by increasing bacterial killing, inactivating bacterial virulence factors, and inactivating host cytokines that impair periodontal restoration. Therefore, aPDT treatment may provide a more favorable healing environment.

Cited by 111 publications

References 47 publications

Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases

Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases

Effect of Antimicrobial Photodynamic Therapy as an Adjunct to Nonsurgical Treatment of Deep Periodontal Pockets: A Clinical Study

All you need is light

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