Antimicrobial photodynamic therapy in endodontic reintervention: A systematic review and meta-analysis

Nunes, Larissa Pereira; Nunes, Gabriel Pereira; Ferrisse, Túlio Morandin; Strazzi-Sahyon, Henrico Badaoui; Cintra, Luciano Tavares Ângelo; Santos, Paulo Henrique dos; Sivieri-Araújo, Gustavo

doi:10.1016/j.pdpdt.2022.103014

Cited by 14 publications

(2 citation statements)

References 37 publications

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“…Despite significant results after aPDT application for the reduction of microbial load against many types of microorganisms [ 12 , 13 , 14 , 15 , 16 , 17 ], studies have been conducted to enhance the efficacy of aPDT [ 18 ]. In this context, a diverse type of nanoparticles has been used as a drug delivery system facilitating the photosensitizer uptake in microbial cells and improving bioavailability, solubility, permeability, and selectivity [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis

et al. 2022

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Antimicrobial photodynamic therapy (aPDT) is a method that does not seem to promote antimicrobial resistance. Photosensitizers (PS) conjugated with inorganic nanoparticles for the drug-delivery system have the purpose of enhancing the efficacy of aPDT. The present study was to perform a systematic review and meta-analysis of the efficacy of aPDT mediated by PS conjugated with inorganic nanoparticles. The PubMed, Scopus, Web of Science, Science Direct, Cochrane Library, SciELO, and Lilacs databases were searched. OHAT Rob toll was used to assess the risk of bias. A random effect model with an odds ratio (OR) and effect measure was used. Fourteen articles were able to be included in the present review. The most frequent microorganisms evaluated were Staphylococcus aureus and Escherichia coli, and metallic and silica nanoparticles were the most common drug-delivery systems associated with PS. Articles showed biases related to blinding. Significant results were found in aPDT mediated by PS conjugated with inorganic nanoparticles for overall reduction of microorganism cultured in suspension (OR = 0.19 [0.07; 0.67]/p-value = 0.0019), E. coli (OR = 0.08 [0.01; 0.52]/p-value = 0.0081), and for Gram-negative bacteria (OR = 0.12 [0.02; 0.56/p-value = 0.0071). This association approach significantly improved the efficacy in the reduction of microbial cells. However, additional blinding studies evaluating the efficacy of this therapy over microorganisms cultured in biofilm are required.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis

et al. 2022

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“…The symbiotic bacterial communities that they wish to eliminate are of the Gram-positive type, mostly [ 8 ], since these can adhere to the dentin of the root canal, creating an encapsulation with a self-produced matrix of extracellular polymeric compounds that results in the formation of a biofilm, becoming more resistant to antibacterial compounds [ 9 , 10 ]. Biofilms are the leading cause of primary and secondary root canal infections [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Theoretical Study at the Molecular Mechanics Level of the Interaction of Tetracycline and Chloramphenicol with the Antibiotic Receptors Present in Enterococcus faecalis (Q839F7) and Streptococcus mutans (Q8DS20)

et al. 2022

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When dental infections occur, various types of antibiotics are used to combat them. The most common antibiotics to be used are tetracycline and chloramphenicol; likewise, the most common bacteria in dental infections are Enterococcus faecalis and Streptococcus mutans. In the present work, we have studied by molecular mechanics methods the interactions of the ribosomal proteins L16 present in Enterococcus faecalis and Streptococcus mutans, identified with UNIPROT code Q839F7 and Q8DS20, respectively. We evaluated the interactions between Q839F7 and Q8DS20 with tetracycline and chloramphenicol antibiotics. We found that the interaction between Enterococcus faecalis (Q839F7) is much more favorable when treated with chloramphenicol. In contrast, the interaction with tetracycline is favored in the case of Q8DS20 present in Streptococcus mutans. This suggests that the treatment should be differentiated depending on the infection level and the presence of some of these bacteria.

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Antimicrobial effectiveness of ultrasonic irrigation in root canal treatment: a systematic review of randomized clinical trials and meta-analysis

et al. 2023

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Antimicrobial photodynamic therapy in endodontic reintervention: A systematic review and meta-analysis

Cited by 14 publications

References 37 publications

Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis

Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis

Theoretical Study at the Molecular Mechanics Level of the Interaction of Tetracycline and Chloramphenicol with the Antibiotic Receptors Present in Enterococcus faecalis (Q839F7) and Streptococcus mutans (Q8DS20)

Antimicrobial effectiveness of ultrasonic irrigation in root canal treatment: a systematic review of randomized clinical trials and meta-analysis

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