Antimicrobial photodynamic therapy combined to periodontal treatment: Experimental model

Belinello-Souza, Estéfani L.; Alvarenga, Letícia Heineck; Lima-Leal, Cintia; Almeida, Patrícia de; Leite, Carolina Guimarães; Lima, Tairine R.; Godoy-Miranda, Bianca; Previati-Oliveira, Jhosepher; Pretto, Lucas de; Freitas, Anderson Zanardi de; Fernandes, Adjaci Uchôa; Marcos, Rodrigo Labat; Prates, Renato Araújo

doi:10.1016/j.pdpdt.2017.03.008

Cited by 11 publications

(6 citation statements)

References 28 publications

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“…A turning point in this regard was a dual strategy using microarc oxidation + poly (amidoamine)-loading dimethylaminododecyl methacrylate (PD) to combat biofilm formation that achieved promising results against peri-implantitis [ 87 , 98 ]. Prates et al stated that using protoporphyrin derivative as an antimicrobial photodynamic therapy agent exhibits 30% dental bone recovery [ 99 ]. Moreover, poly (ethylene) glycol-poly ( β -amino esters) micelles have been conjugated with other antimicrobials and could fairly eradicate S. aureus infection [ 100 ].…”

Section: Animal Studies Of Chemical Materials In Oral Biofilm Treatmentsmentioning

confidence: 99%

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Moghaddam

Ranjbar

Yazdanian

et al. 2022

BioMed Research International

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Herbal and chemical products are used for oral care and biofilm treatment and also have been reported to be controversial in the massive trials conducted in this regard. The present review is aimed at evaluating the potential of relevant herbal and chemical products and comparing their outcomes to conventional oral care products and summarizing the current state of evidence of the antibiofilm properties of different products by evaluating studies from the past eleven years. Chlorhexidine gluconate (CHX), essential oils (EOs), and acetylpyridinium chloride were, respectively, the most commonly studied agents in the included studies. As confirmed by all systematic reviews, CHX and EO significantly control the plaque formation and gingival indices. Fluoride is another interesting reagent in oral care products that has shown promising results of oral health improvement, but the evidence quality needs to be refined. The synergy between natural plants and chemical products should be targeted in the future to accede to the formation of new, efficient, and healthy anticaries strategies. Moreover, to discover their biofilm-interfering or biofilm-inhibiting activities, effective clinical trials are needed. In this review article, therapeutic applications of herbal/chemical materials in oral biofilm infections are discussed in recent years (2010-2022).

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Section: Animal Studies Of Chemical Materials In Oral Biofilm Treatmentsmentioning

confidence: 99%

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Moghaddam

Ranjbar

Yazdanian

et al. 2022

BioMed Research International

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“…Belinello-Souza et al found that to the treated animals with aPDT compared with scaling and root planning (SRP) group, the bone gain was approximately 30%, following 7 days after periodontal intervention. [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Photodynamic Therapy with Natural Photosensitizers in the Management of Periodontal Disease Induced in Rats

Dascalu

Moldovan

Saroși

et al. 2022

Gels

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This study aims to investigate the effect of new natural photosensitizers (PS) (based on oregano essential oil, curcuma extract, and arnica oil) through in vitro cytotoxicity and biological tests in rat-induced periodontal disease, treated with photodynamic therapy (aPDT). The cytotoxicity of PS was performed on human dental pulp mesenchymal stem cells (dMSCs) and human keratinocyte (HaCaT) cell lines. Periodontal disease was induced by ligation of the first mandibular molar of 25 rats, which were divided into 5 groups: control group, periodontitis group, Curcuma and aPDT-treated group, oregano and aPDT-treated group, and aPDT group. The animals were euthanized after 4 weeks of study. Computed tomography imaging has been used to evaluate alveolar bone loss. Hematological and histological evaluation showed a greater magnitude of the inflammatory response and severe destruction of the periodontal ligaments in the untreated group.. For the group with the induced periodontitis and treated with natural photosensitizers, the aPDT improved the results; this therapy could be an important adjuvant treatment. The obtained results of these preliminary studies encourage us to continue the research of periodontitis treated with natural photosensitizers activated by photodynamic therapy.

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“…Antimicrobial photodynamic therapy (APDT), also known as photodynamic antimicrobial chemotherapy (PACT), was used in periodontal treatment based on scaling and root planing, as an adjunct form to decrease the bacterial load in the periodontal pocket and avoid using systemic antimicrobials (1)(2)(3). APDT for periodontitis consists of the topical administration of a photosensitizer (PS) that is distributed within the periodontal pockets with accumulation on microbial biofilms.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial photodynamic therapy mediated by methylene blue in surfactant vehicle on periodontopathogens

Tortamano

Anselmo

Kassa

et al. 2020

Photodiagnosis and Photodynamic Therapy

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Background: Periodontal disease (PD) is a chronic inflammatory disease caused by the presence of microbial biofilm. The aim of this study was to evaluate antimicrobial effect of antimicrobial photodynamic therapy (APDT) mediated by methylene blue (MB) in monomer form on A. actinomycetemcomitans and P. gingivalis.Methods: A. actinomycetemcomitans ATCC 29523 and P. gingivalis ATCC 33577 were cultured on anaerobic jars at 37°C for 48 h, and we tested APDT in the presence of 0.25% sodium dodecyl sulfate (SDS) in phosphate-buffered saline (PBS) or in PBS alone. APDT was carried out with 100 µM MB under laser radiation (PhotolaseIII, DMC, Brazil) at ʎ = 660 nm and parameters as following (P = 100 mW; I = 250 mW/cm 2 , and doses of 15, 45 and 75 J/cm 2 ).Results: Following APDT, PBS groups of A. actinomycetemcomitans presented 4 Logs of microbial death after 5 min irradiation. However, there was no bacterial reduction in SDS groups. On the other hand, P. gingivalis was sensitive to APDT in the presence of 0.25% SDS with 2 logs reduction from dark toxicity. Conclusion:The presence of 0.25% SDS can lead to different responses depending on the different microbial species.

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Antimicrobial photodynamic therapy combined to periodontal treatment: Experimental model

Cited by 11 publications

References 28 publications

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Photodynamic Therapy with Natural Photosensitizers in the Management of Periodontal Disease Induced in Rats

Antimicrobial photodynamic therapy mediated by methylene blue in surfactant vehicle on periodontopathogens

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