Antimicrobial photodynamic therapy by means of porphycene photosensitizers

Masiera, Natalia; Bojarska, Agnieszka; Gawryszewska, Iwona; Sadowy, Ewa; Hryniewicz, Waleria; Waluk, Jacek

doi:10.1016/j.jphotobiol.2017.07.016

Cited by 32 publications

(22 citation statements)

References 30 publications

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“…The obtained killing rate for 1 at 10 −5 M concentration can be considered as total bacteria eradication. The same S. aureus photokilling level at similar dosimetry was reported by Masiera and co-workers, who noted 6 log (complete eradication) reduction in bacterial growth for unsubstituted porphycene (II, Figure 3 ) loaded into micelles at the concentration of 7 × 10 −6 M [ 58 ]. Another macrocycle, phthalocyanine IV ( Figure 3 ), presented higher activity at 10 −4 M than at 10 −5 M [ 59 ], which can be linked to a decreased tendency to form aggregates as the result of electrostatic repulsion between single molecules.…”

Section: Resultssupporting

confidence: 79%

“…Studied macrocycles revealed S. epidermidis photokilling rate at log values similar to those measured for S. aureus , up to over 5.7 log (10 −5 M). Interestingly, macrocycle II loaded into pluronic micelles has reduced S. epidermidis colonies at the dose of 7 × 10 −6 M and the light dose of only 6 J/cm 2 [ 58 ]. A well-known photosensitizer, chlorin e6 (III, Figure 3 ), presented 6 log reduction in S. epidermidis growth when it was delivered at the same concentration (10 −5 M), but using a 2-fold higher light dose (55 J/cm 2 ) [ 65 ], in comparison to 1 and 2.…”

Section: Resultsmentioning

confidence: 99%

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Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria

Stolarska

Glowacka-Sobotta

Mlynarczyk

et al. 2020

IJMS

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Magnesium(II) tribenzoporphyrazines with phenoxybutylsulfanyl substituents were evaluated as photosensitizers in terms of their optical properties against wound bacteria. In the UV-vis spectra of analyzed tribenzoporphyrazines, typical absorption ranges were found. However, the emission properties were very weak, with fluorescence quantum yields in the range of only 0.002–0.051. What is important, they revealed moderate abilities to form singlet oxygen with the quantum yields up to 0.27. Under irradiation, the macrocycles decomposed via photobleaching mechanism with the quantum yields up to 8.64 × 10−5. The photokilling potential of tribenzoporphyrazines was assessed against Streptococcus pyogenes, Staphylococcus epidermidis, as well as various strains of Staphylococcus aureus, including methicillin-sensitive and-resistant bacteria. Both evaluated photosensitizers revealed high photodynamic potential against studied bacteria (>3 logs). S.aureus growth was reduced by over 5.9 log, methicillin-resistant S. aureus by 5.1 log, S.epidermidis by over 5.7 log, and S. pyogenes by over 4.7 log.

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria

Stolarska

Glowacka-Sobotta

Mlynarczyk

et al. 2020

IJMS

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“…Cationic PSs with positive charges are more active against the negatively charged bacterial cell walls and are more efficient in antibacterial treatment (Spagnul, Turner & Boyle, 2015). There are several PSs that are known to exhibit antibacterial and antibiofilm effects; for example porphyrins, chlorins, bacteriochlorins, phenothiazines and phthalocyanines (Masiera et al, 2017). In the present study, malachite green (MG), which is a cationic photosensitizing molecule with photodynamic effects at 615 nm in the range of red light in the visible spectrum, has been used as the PS (Junqueira et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial photodynamic therapy on Staphylococcus aureus and Escherichia coli using malachite green encapsulated mesoporous silica nanoparticles: an in vitro study

Parasuraman

Siddhardha

et al. 2019

PeerJ

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Background Rise in the number of healthcare associated or hospital acquired infections is a major problem affecting the global healthcare sector. We evaluated superior antibacterial and antibiofilm photodynamic therapy (aPDT) using malachite green encapsulated mesoporous silica nanoparticles (MG-MSN) against Staphylococcus aureus and Escherichia coli, which are known to be major causative agents of nosocomial infections. Methods Malachite green (MG) was encapsulated on mesoporous silica nanoparticles (MSN). Fourier-transform infrared spectroscopy, Transmission electron microscopy, and spectroscopic analysis were performed to characterize the MG-MSN. The antimicrobial efficacies of MSN, MG, and MG-MSN were investigated and the results were recorded. Results MG-MSN was effective against both the tested bacteria. S. aureus was more phototoxic to MG-MSN compared to E. coli. The antibiofilm efficacy of MG-MSN on E. coli and S. aureus was also studied. Biofilm inhibition was 65.68 ± 2.62% in E. coli and 79.66 ± 3.82% in S. aureus. Cell viability assay, exopolysaccharides quantification, and confocal laser scanning microscopy studies also revealed the enhanced antibiofilm activity of MG-MSN when used as a potential photosensitizer for aPDT. This study can be extended to eradicate these strains from localized superficial infections and medical appliances, preventing nosocomial infections.

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“…The results obtained with macrocycles such as porphyrins, (Alves et al 2015), phthalocyanines (Dei et al 2006, Pereira et al 2012, Ryskova et al 2013, Lourenço et al 2015, Marciel et al 2017 or porphycenes (Xavier et al 2010, RuizGonzález et al 2015, Masiera et al 2017) are particularly relevant. The discovery that positively charged PS at physiological pH values promote the photoinactivation of microbial cells, namely of antibiotic resistant Gram-negative bacteria has stimulated the development of new useful cationic PS for PDI.…”

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confidence: 99%

Evaluation of meso-substituted cationic corroles as potential antibacterial agents

Cardote

Barata

Amador

et al. 2018

An. Acad. Bras. Ciênc.

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Cationic derivatives of 5,10,15-tris[4-(pyridin-4-ylsulphanyl)-2,3,5,6-tetrafluorophenyl]-corrolategallium(III) pyridine and 5,10,15-tris[4-(pyridin-2-ylsulfanyl)-2,3,5,6-tetrafluorophenyl]-correlategallium(III)pyridine were synthesized and their photosensitizing properties against the naturally bioluminescent Gram-negative bacterium Allivibrio fischeri were evaluated. The cationic corrole derivatives exhibited antibacterial activity at micromolar concentrations against this Gram-negative bacterium strain.

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Antimicrobial photodynamic therapy by means of porphycene photosensitizers

Cited by 32 publications

References 30 publications

Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria

Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria

Antimicrobial photodynamic therapy on Staphylococcus aureus and Escherichia coli using malachite green encapsulated mesoporous silica nanoparticles: an in vitro study

Evaluation of meso-substituted cationic corroles as potential antibacterial agents

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