Antimicrobial Pharmacokinetic Considerations in Extracorporeal Membrane Oxygenation
Kevin Johns,
Gregory Eschenauer,
Angela Clark
et al.
Abstract:Critical illness creates challenges for healthcare providers in determining the optimal treatment of severe disease, particularly in determining the most appropriate selection and dosing of medications. Critically ill patients experience endogenous physiologic changes that alter the pharmacokinetics (PKs) of medications. These alterations can be further compounded by mechanical support modalities such as extracorporeal membrane oxygenation (ECMO). Specific components of the ECMO circuit have the potential to a… Show more
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