Antimicrobial Peptides: Roles in Periodontal Health and Disease

Jönsson, Daniel

doi:10.1007/978-3-319-53737-5_8

Cited by 2 publications

(1 citation statement)

References 124 publications

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“…However, when it comes to the complex and intricate homeostasis between the microbiome and HDPs in the oral cavity, the neutralizing effects of HDPs on bacterial endotoxins may be more important, as it occurs at lower concentrations of HDPs typically associated with health. Also, the HDPs have several additional features like they are chemotactic for leukocytes or are involved in the regulation of cell proliferation, epithelialization, angiogenesis, wound healing, or adaptive immunity [6].…”

Section: Antimicrobial Action Of Hdpsmentioning

confidence: 99%

Fathoming the Role of Host Defence Peptides in Periodontal Health and Disease

Guruprasad

Bhavani

Ramadevi

2021

MRD

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The periodontal epithelium neighbouring the tooth is precise to form a seal and attachment around the tooth. This function is challenged by development of bacterial biofilm and the host response to biofilm bacteria and their toxins leading to certain vulnerabilities allied with periodontal disease. Oral epithelial cells counters the microbial challenges from dental plaque by the production of host defence peptides (HDP's), chemokines and cytokines that boost inflammation and immune response of periodontal tissues. Host defence peptides are diverse group of biologically active molecules with multidimensional properties. Besides their direct antimicrobial function, they have multiple roles as mediators of inflammation with impact on epithelial and inflammatory cells influencing diverse processes such as cytokine release, cell proliferation, angiogenesis, wound healing, chemotaxis, immune induction, and protease-antiprotease balance. In the oral cavity, the HDPs are produced by the salivary glands and the oral epithelium and they are Defensins and Cathelicidin. This mini review summarizes the current understanding of various oral host defence peptides involved in maintaining balance between periodontal health and disease.

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Section: Antimicrobial Action Of Hdpsmentioning

confidence: 99%

Fathoming the Role of Host Defence Peptides in Periodontal Health and Disease

Guruprasad

Bhavani

Ramadevi

2021

MRD

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A Comprehensive Multi-Omic Approach Reveals a Relatively Simple Venom in a Diet Generalist, the Northern Short-Tailed Shrew, Blarina brevicauda

Hanf

Chavez

2020

Genome Biology and Evolution

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Animals that use venom to feed on a wide diversity of prey may evolve a complex mixture of toxins to target a variety of physiological processes and prey-defense mechanisms. Blarina brevicauda, the northern-short tailed shrew, is one of few venomous mammals, and is also known to eat evolutionarily divergent prey. Despite their complex diet, earlier proteomic and transcriptomic studies of this shrew’s venom have only identified two venom proteins. Here, we investigated with comprehensive molecular approaches whether B. brevicauda venom is more complex than previously understood. We generated de novo assemblies of a B. brevicauda genome and submaxillary-gland transcriptome, as well as sequenced the salivary proteome. Our findings show that B. brevicauda’s venom composition is simple relative to their broad diet and is likely limited to seven proteins from six gene families. Additionally, we explored expression levels and rate of evolution of these venom genes and the origins of key duplications that led to toxin neofunctionalization. We also found three proteins that may be involved in endogenous self-defense. The possible synergism of the toxins suggests that vertebrate prey may be the main target of the venom. Further functional assays for all venom proteins on both vertebrate and invertebrate prey would provide further insight into the ecological relevance of venom in this species.

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Antimicrobial Peptides: Roles in Periodontal Health and Disease

Cited by 2 publications

References 124 publications

Fathoming the Role of Host Defence Peptides in Periodontal Health and Disease

Fathoming the Role of Host Defence Peptides in Periodontal Health and Disease

A Comprehensive Multi-Omic Approach Reveals a Relatively Simple Venom in a Diet Generalist, the Northern Short-Tailed Shrew, Blarina brevicauda

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