Antimicrobial Peptides: Potential Application in Liver Cancer

Zhang, Chunye; Yang, Ming; Ericsson, Aaron C.

doi:10.3389/fmicb.2019.01257

Cited by 69 publications

(71 citation statements)

References 69 publications

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“…Current evidences indicate that they exhibit antimicrobial activity against many kinds of microorganisms including fungi, bacteria and enveloped viruses, the ability to neutralize endotoxin, immunomodulating property, etc. (Maroti et al, 2011;Khurshid et al, 2017;Zhang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The Critical Role of Tryptophan in the Antimicrobial Activity and Cell Toxicity of the Duck Antimicrobial Peptide DCATH

et al. 2020

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Antimicrobial peptides (AMPs) have attracted more attention for their potential candidates for new antibiotic drugs. As a novel identified cathelicidin AMP from duck, dCATH owns broad-spectrum antimicrobial activities but with a noticeable toxicity. To explore dCATH-derived AMPs with reduced cell toxicity and improved cell selectivity, a series of truncated and tryptophan-replaced peptides of dCATH were designed. Two truncated peptides containing one of the two tryptophan (Trp) residues at the positions of 4 and 17 (W4 and W17) of dCATH, dCATH(1-16) and dCATH(5-20), showed strong antibacterial activity, but didn't show obvious hemolytic activity and cytotoxicity. The derived peptides not containing Trp didn't possess obvious antimicrobial activity, and their hemolytic and cytotoxic effect was also diminished. Also as evidence by Trp fluorescence experiment that existence of W4 and W17 was crucially important to the antimicrobial activity, hemolysis and cytotoxicity of dCATH, and one of the two Trp residues was competent and necessary to retain its antimicrobial activity. Antibacterial mechanism analysis showed that dCATH(1-16) and dCATH(5-20) killed bacterial cells by increasing permeability and causing a loss of membrane integrity. dCATH(1-16) and dCATH(5-20) possessed insignificant inhibitory activity against levels of IL-6, TNF-α, and NO in RAW 264.7 cells treated with LPS. In vivo, intraperitoneal administration of the two peptides significantly decreased mortality and provided protection against LPS-induced inflammation in mice challenged with lethal dose of LPS. The two peptides, dCATH(1-16) and dCATH(5-20), which possessed high antibacterial activity and cell selectivity, may herald development prospects as new antibacterial agents in the future.

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Section: Introductionmentioning

confidence: 99%

The Critical Role of Tryptophan in the Antimicrobial Activity and Cell Toxicity of the Duck Antimicrobial Peptide DCATH

et al. 2020

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“…Manuscript to be reviewed include hepatitis B or C virus infections, the intake of aflatoxin, alcohol abuse and non-alcoholic fatty liver disease (NAFLD) (Zhang et al 2019). Due to the lack of effective diagnostic and prognostic evaluation methods, the mortality rates of liver cancer patients have gradually increased.…”

Section: Discussionmentioning

confidence: 99%

Peer Review #3 of "Clinical characteristics and prognostic value of MEX3A mRNA in liver cancer (v0.2)"

2020

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Background. MEX3A is an RNA-binding proteins (RBPs) that promotes the proliferation, invasion, migration and viability of cancer cells. The aim of this study was to explore the clinicopathological characteristics and prognostic significance of MEX3A mRNA expression in liver cancer. Methods. RNA-Seq and clinical data were collected from The Cancer Genome Atlas (TCGA). Boxplots were used to represent discrete variables of MEX3A. Chisquare tests were used to analyze the correlation between clinical features and MEX3A expression. Receiver operating characteristic (ROC) curves were used to confirm diagnostic ability. Independent prognostic ability and values were assessed using Kaplan-Meier curves and Cox analysis. Results. We acquired MEX3A RNA-Seq from 50 normal liver tissues and 373 liver cancer patients along with clinical data. We found that MEX3A was up-regulated in liver cancer which increased according to histological grade (p<0.001). MEX3A showed moderate diagnostic ability for liver cancer (AUC=0.837). Kaplan-Meier curves and Cox analysis revealed that the high expression of MEX3A was significantly associated with poor survival (OS and RFS) (p<0.001). Moreover, MEX3A was identified as an independent prognostic factor of liver cancer (p<0.001). Conclusions. MEX3A expression shows promise as an independent predictor of liver cancer prognosis.

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“…It is assumed that exogenous peptides of natural origin can activate new interactions in the hepatic cells, violating the cascades of reactions involving TGF-β1 and glypican-3 and thereby improving the disease prognosis. [37]. These assumptions need future studies and researches will continue.…”

Section: Indicatorsmentioning

confidence: 98%

Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence

Shypulin¹,

Stoliarova²,

Konovalenko³

et al. 2019

AJBLS

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An article deals with the influence of the transforming growth factor beta-1 (TGF-β1) on the carcinogenesis of hepatic cells, as well as attention is given to the role of this factor in the hepatocellular carcinoma (HCC) progression. We monitored two groups of patients: in the treatment group, patients were administered cancer vaccine therapy and anti-relapse immune corrector Arecur®-a complex of exogenous peptides with anti-inflammatory, anti-infective and regenerating properties; in the reference group, patients were not administered immune corrector. The study showed that the cancer vaccine has a positive effect on the activity of T-cell immunity and interleukin-2 expression level. The result of the inclusion of antirelapse immune corrector Arecur® in the patients' management regimen was the reduction of TGF-β1 expression. The lower recurrence rate of HCC in the treatment group suggests that Arecur® may prevent possible recurrences and metastasis of HCC by limiting TGF-β1 expression. Future researches of anti-relapse immune correction regimens for patients with hepatic tumours may improve the therapeutic strategy and prevention of the disease progression in the long term. In addition, immune correction using exogenous peptides is likely capable of preventing the malignancy in patients with chronic hepatitis and liver cirrhosis.

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Antimicrobial Peptides: Potential Application in Liver Cancer

Cited by 69 publications

References 69 publications

The Critical Role of Tryptophan in the Antimicrobial Activity and Cell Toxicity of the Duck Antimicrobial Peptide DCATH

The Critical Role of Tryptophan in the Antimicrobial Activity and Cell Toxicity of the Duck Antimicrobial Peptide DCATH

Peer Review #3 of "Clinical characteristics and prognostic value of MEX3A mRNA in liver cancer (v0.2)"

Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence

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