Antimicrobial peptides, nanotechnology, and natural metabolites as novel approaches for cancer treatment

Leite, Michel Lopes; Cunha, Nicolau Brito da; Costa, Fabrício F.

doi:10.1016/j.pharmthera.2017.10.010

Cited by 57 publications

(28 citation statements)

References 208 publications

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“…Apart from the above listed AMPs, there is an ever growing body of research involving natural or synthetic peptides. Such studies have used nano-carriers to encapsulate AMPs as therapeutics and immunomodulators ( Leite et al, 2017 ). Small synthetic peptides have been evaluated against resistant bacteria in vitro; these peptides are developed from computer algorithms which evaluate their possible interaction with the surface chemistry of known microorganisms ( Cruz et al, 2017 ).…”

Section: Nanotechnology Involvement In the Delivery Of Antimicrobial mentioning

confidence: 99%

“…Regarding the application of nano delivery systems as a potential anti-tumor therapeutic, such systems can take advantage of the tumor microenvironment, which is over supplied with blood vessels but tends to lack lymphatic drainage ( Narang and Varia, 2011 ). Nanoparticles can be retained in the tumor through what is known as the enhanced permeation and retention (EPR) effect ( Narang and Varia, 2011 ; Leite et al, 2017 ). This effect can be explored via passive targeting, as the size of nanoparticles is key in enhancing retention.…”

Section: Nanotechnology Involvement In the Delivery Of Antimicrobial mentioning

confidence: 99%

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Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges

et al. 2018

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Antimicrobial peptides are sequences of amino acids, which present activity against microorganisms. These peptides were discovered over 70 years ago, and are abundant in nature from soil bacteria, insects, amphibians to mammals and plants. They vary in amino acids number, the distance between amino acids within individual peptide structure, net charge, solubility and other physical chemical properties as well as differ in mechanism of action. These peptides may provide an alternative treatment to conventional antibiotics, which encounter resistance such as the peptide nisin applied in treating methicillin resistant Staphylococcus aureus (MRSA) or may behave synergistically with known antibiotics against parasites for instance, nisin Z when used in synergy with ampicillin reported better activity against Pseudomonas fluorescens than when the antibiotic was alone. AMPs are known to be active against viruses, bacteria, fungi and protozoans. Nanotechnology is an arena which explores the synthesis, characterization and application of an array of delivery systems at a one billionth of meter scale. Such systems are implemented to deliver drugs, proteins, vaccines, and peptides. The role of nanotechnology in delivering AMPs is still at its early development stage. There are challenges of incorporating AMPs into drug delivery system. This review intends to explore in depth, the role of nanotechnology in delivering AMPs as well as presenting the current advances and accompanying challenges of the technology.

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Section: Nanotechnology Involvement In the Delivery Of Antimicrobial mentioning

confidence: 99%

Section: Nanotechnology Involvement In the Delivery Of Antimicrobial mentioning

confidence: 99%

Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges

et al. 2018

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“…The first interaction with proteins was discovered in 1972 [ 6 ]. Proteins capable of such interactions are called hyaladherins [ 7 ], e.g., HARE, which controls the endocytosis of hyaluronan [ 8 , 9 ]; LYVE1 [ 5 , 9 ], which is structurally similar to the CD44 receptor [ 9 ]; and many others including, intracellular receptors whose functions have not yet been fully clarified [ 10 ]. For most hyaluronan binding proteins, a domain of about 100 amino acids, known as the “Link module,” is responsible for binding [ 5 , 8 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan-Arginine Interactions—An Ultrasound and ITC Study

Jugl

Pekař

2020

Polymers

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High-resolution ultrasound spectroscopy and isothermal titration calorimetry were used to characterize interactions between hyaluronan and arginine oligomers. The molecular weight of arginine oligomer plays an important role in interactions with hyaluronan. Interactions were observable for arginine oligomers with eight monomer units and longer chains. The effect of the ionic strength and molecular weight of hyaluronan on interactions was tested. In an environment with increased ionic strength, the length of the arginine oligomer was crucial. Generally, sufficiently high ionic strength suppresses interactions between hyaluronan and arginine oligomers, which demonstrated interactions in water. From the point of view of the molecular weight of hyaluronan, the transition between the rod conformation and the random coil conformation appeared to be important.

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“…Also, because it is likely that CARPs interact with negatively charged cell membrane structures, an interaction that appears to be critical for neuroprotection, the mechanisms associated with the affinity of CARPs to cell membranes will also be discussed. Interestingly, it is the interaction of CARPs with negatively charged bacterial and cancer cell cytoplasmic membrane structures that is considered to be one of the mechanisms responsible for their anti-bacterial and anti-cancer properties (213,214).…”

Section: Further Validation and Characterization Of Carps As Neuropromentioning

confidence: 99%

Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

2020

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There are virtually no clinically available neuroprotective drugs for the treatment of acute and chronic neurological disorders, hence there is an urgent need for the development of new neuroprotective molecules. Cationic arginine-rich peptides (CARPs) are an expanding and relatively novel class of compounds, which possess intrinsic neuroprotective properties. Intriguingly, CARPs possess a combination of biological properties unprecedented for a neuroprotective agent including the ability to traverse cell membranes and enter the CNS, antagonize calcium influx, target mitochondria, stabilize proteins, inhibit proteolytic enzymes, induce pro-survival signaling, scavenge toxic molecules, and reduce oxidative stress as well as, having a range of anti-inflammatory, analgesic, anti-microbial, and anti-cancer actions. CARPs have also been used as carrier molecules for the delivery of other putative neuroprotective agents across the blood-brain barrier and blood-spinal cord barrier. However, there is increasing evidence that the neuroprotective efficacy of many, if not all these other agents delivered using a cationic arginine-rich cell-penetrating peptide (CCPPs) carrier (e.g., TAT) may actually be mediated largely by the properties of the carrier molecule, with overall efficacy further enhanced according to the amino acid composition of the cargo peptide, in particular its arginine content. Therefore, in reviewing the neuroprotective mechanisms of action of CARPs we also consider studies using CCPPs fused to a putative neuroprotective peptide. We review the history of CARPs in neuroprotection and discuss in detail the intrinsic biological properties that may contribute to their cytoprotective effects and their usefulness as a broad-acting class of neuroprotective drugs.

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Antimicrobial peptides, nanotechnology, and natural metabolites as novel approaches for cancer treatment

Cited by 57 publications

References 208 publications

Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges

Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges

Hyaluronan-Arginine Interactions—An Ultrasound and ITC Study

Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

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