Antimicrobial peptides for the prevention and treatment of dental caries: A concise review

Niu, John Yun; Yin, Iris Xiaoxue; Wu, William Ka Kei; Li, Quanli; Mei, May Lei; Chu, Chun Hung

doi:10.1016/j.archoralbio.2020.105022

Cited by 60 publications

(72 citation statements)

References 91 publications

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“…Interest in the development of antimicrobial peptides as anticancer agents is growing. Some cationic peptides from the Antimicrobial Peptide Database have shown selectivity toward tumor cells (Kuroda et al, 2015;Niu et al, 2021). This is due to the negative membrane potential over the cytoplasmic membranes of many types of cancer cells, which attract cationic peptides (Utsugi et al, 1991).…”

Section: Some Antimi Crob Ial Pep Tide S Are Tumor Suppre Ssor Smentioning

confidence: 99%

“…Antimicrobial peptides have the potential to be used in managing oral diseases, including dental caries, periodontal diseases, oral mucosal diseases and oral cancer (Figure 1). In addition, some databases were specifically developed for the properties and application of antimicrobial peptides (Niu et al, 2021). This narrative review is aimed at providing an overview of the role of antimicrobial peptides in the response to and treatment of oral diseases by collecting information from different databases.…”

Section: Introductionmentioning

confidence: 99%

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The multifaceted roles of antimicrobial peptides in oral diseases

Niu

Yin

Mei

et al. 2021

Molecular Oral Microbiology

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Antimicrobial peptides are naturally occurring protein molecules with antibacterial, antiviral and/or antifungal activity. Some antimicrobial peptides kill microorganisms through direct binding with negatively charged microbial surfaces. This action disrupts the cytoplasmic membrane and leads to the leakage of the cytoplasm. In addition, they are involved in the innate immune response. Antimicrobial peptides play an important role in oral health, as natural antimicrobial peptides are the first line of host defence in response to microbial infection. The level of natural antimicrobial peptides increases during severe disease conditions and play a role in promoting the healing of oral tissues. However, they are insufficient for eliminating pathogenic micro-organisms. The variability of the oral environment can markedly reduce the effect of natural antimicrobial peptides. Thus, researchers are developing synthetic antimicrobial peptides with promising stability and biocompatibility. Synthetic antimicrobial peptides are a potential alternative to traditional antimicrobial therapy.Pertinent to oral diseases, the deregulation of antimicrobial peptides is involved in the pathogenesis of dental caries, periodontal disease, mucosal disease and oral cancer, where they can kill pathogenic microorganisms, promote tissue healing, serve as biomarkers and inhibit tumor cells. This narrative review provides an overview of the multifaceted roles of antimicrobial peptides in oral diseases.

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Section: Some Antimi Crob Ial Pep Tide S Are Tumor Suppre Ssor Smentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The multifaceted roles of antimicrobial peptides in oral diseases

Niu

Yin

Mei

et al. 2021

Molecular Oral Microbiology

Self Cite

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show abstract

“…Further, they play role in stimulation of wound healing and angiogenesis. Due to their antibacterial, anti-inflammatory, and/or immune modulatory actions, they are used to control oral infections [108][109][110][111][112][113][114]. Sani et al [89] have developed a hydrogel based on a visiblelight-activated naturally derived polymer (gelatin) and an antimicrobial peptide (AMP) for treatment of peri-implant diseases.…”

Section: Hydrogelsmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan²,

Akca

2021

Drug Deliv. and Transl. Res.

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Oral health reflects the general health, and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection-related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed, and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

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“…Further, they play role in stimulation of wound healing and angiogenesis. Due to their antibacterial, anti-in ammatory and/or immune modulatory actions, they are used to control oral infections [104][105][106][107][108][109][110]. Sani et al [84] have developed a hydrogel based on a visible-light-activated naturally derived polymer (gelatin) and an antimicrobial peptide (AMP) for treatment of peri-implant diseases.…”

Section: Micellesmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan

2021

Preprint

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Oral health reflects the general health and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

show abstract

Antimicrobial peptides for the prevention and treatment of dental caries: A concise review

Cited by 60 publications

References 91 publications

The multifaceted roles of antimicrobial peptides in oral diseases

The multifaceted roles of antimicrobial peptides in oral diseases

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

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