Antimicrobial peptides

Rahnamaeian, Mohammad

doi:10.4161/psb.6.9.16319

Cited by 74 publications

(35 citation statements)

References 139 publications

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“…While this promise is evident, it does not come without the need for significantly enhanced studies into the mechanism of action of the compounds and their physiological relevance. One of the complicating factors in this line of study is that the parent model, the antimicrobial peptides, is not fully understood in terms of molecular mechanism . This is partially because of the number and sequence variability in naturally occurring host defense peptides.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…One of the complicating factors in this line of study is that the parent model, the antimicrobial peptides, is not fully understood in terms of molecular mechanism. [74][75][76][77] This is partially because of the number and sequence variability in naturally occurring host defense peptides. In addition, it has been recently reported that the antimicrobial peptides have low affinity multiple targets in bacteria, contrasting to conventional antibiotics which have high affinity specific targets.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Molecular Design, Structures, and Activity of Antimicrobial Peptide‐Mimetic Polymers

Takahashi

Palermo

Yasuhara

et al. 2013

Macromolecular Bioscience

104

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There is an urgent need for new antibiotics which are effective against drug-resistant bacteria without contributing to resistance development. We have designed and developed antimicrobial copolymers with cationic amphiphilic structures based on the mimicry of naturally occurring antimicrobial peptides. These copolymers exhibit potent antimicrobial activity against a broad spectrum of bacteria including methicillin-resistant Staphylococcus aureus with no adverse hemolytic activity. Notably, these polymers also did not result in any measurable resistance development in E. coli. The peptide-mimetic design principle offers significant flexibility and diversity in the creation of new antimicrobial materials and their potential biomedical applications.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Molecular Design, Structures, and Activity of Antimicrobial Peptide‐Mimetic Polymers

Takahashi

Palermo

Yasuhara

et al. 2013

Macromolecular Bioscience

104

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“…To improve the adhesion of microgels to biological surfaces we envisioned the use of amphiphilic anchor peptides [22] with sizes ranging from 20-100 amino acids.T he anchor peptides exhibit attractive forces by changes in their structure from random coil to more defined secondary structures that determine their mode of action on destabilizing biological membranes. [23] Herein, we report the synthesis of anovel fertilizer system based on pH-responsive,b iohybrid poly(allylamine) microgels.D eveloped microgels exhibit two key features:1 )engineered interior for selective loading of micronutrients (metal ions) and 2) surface decorated with anchor peptides for strong binding to the leaf surface (Scheme 1). Them icrogels were loaded with the micronutrient Fe 3+ and deposited on irondeficient cucumber leaves to demonstrate the efficiencyofthe new nutrient delivery system.…”

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confidence: 99%

Biofunctional Microgel‐Based Fertilizers for Controlled Foliar Delivery of Nutrients to Plants

et al. 2017

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Foliar application of micronutrients (e.g. Fe ) onto plants over an extended time is challenging and often not possible due to insufficient rainfastness. Smart delivery systems which enable micronutrient release over several weeks would offer innovative and sustainable options to improve plant health and food production. Herein, we report a novel foliar fertilizer delivery system based on functional pH-responsive biohybrid microgels that have orthogonal functionality as carriers of micronutrients and employ peptides (termed anchor peptides) as foliar adhesion promoters. The anchor peptides bind to hydrophobic surfaces and the waxy "islands" of plant leaves. Our system requires no auxiliaries and is loadable, storable, and applicable from aqueous dispersion. We report the synthesis and functionalization of microgels, their loading with Fe ions, and a proof of concept for the biofunctional microgel-based fertilizer system is demonstrated for iron-deficient cucumber plants.

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“…This mechanism of action is not highly specific toward a protein target, which indicates that it may escape the mechanisms involved in multidrug resistance (26). The higher efficiency of lycosin-I against MDRAB compared to that of traditional drugs makes it a prospective candidate for overcoming multidrug resistance.…”

mentioning

confidence: 99%

In Vitro Potential of Lycosin-I as an Alternative Antimicrobial Drug for Treatment of Multidrug-Resistant Acinetobacter baumannii Infections

Wang

Liu

et al. 2014

Antimicrob Agents Chemother

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bThe resistance of multidrug-resistant Acinetobacter baumannii (MDRAB) isolates to most traditional antibiotics results in huge challenges for infection therapy. We investigated the in vitro activities of both L-and D-lycosin-I against MDRAB. These two compounds displayed high antibacterial activities and rapid bactericidal effects against MDRAB. Moreover, the compounds retained their activity even at high salt (Mg 2؉ or Ca 2؉ ) concentrations. These results demonstrate the potential of lycosin-I to be developed as a new antibiotic.

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Antimicrobial peptides

Cited by 74 publications

References 139 publications

Molecular Design, Structures, and Activity of Antimicrobial Peptide‐Mimetic Polymers

Molecular Design, Structures, and Activity of Antimicrobial Peptide‐Mimetic Polymers

Biofunctional Microgel‐Based Fertilizers for Controlled Foliar Delivery of Nutrients to Plants

In Vitro Potential of Lycosin-I as an Alternative Antimicrobial Drug for Treatment of Multidrug-Resistant Acinetobacter baumannii Infections

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