Antimicrobial peptides as potent compounds for reduction of COVID-19 infection

Zare‐Zardini, Hadi; Ferdosian, Farzad; Soltaninejad, Hossein; Zahedi, Mahlagha; Memarpoor-Yazdi, Mina; Hamidieh, Amir Ali; Zarezadeh, Mohammad; Eshaghi, Farzaneh Sadat; Jabinian, Fatemeh; Dehghanbaghi, Neda; Mirakhor, Mahnaz; Khnjarpanah, Zohreh

doi:10.21608/bfsa.2021.63262.1074

Cited by 1 publication

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“…This interaction led to the enhancement of peptide stability in various temperatures and acidic conditions. With this strategy, the limitation of low peptide stability was overcome [3,4]. N-9 has spermicidal and antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

“…So, the hydrophilicity of GO and GO-Pd is higher than graphite. This hydrophilicity improves biological and biomedical applications [3,14,55]. Structural stability and changes are the most critical challenge in the functionalization of nanostructures with peptides and proteins [52,56].…”

Section: Discussionmentioning

confidence: 99%

“…Sarcotoxin Pd has been introduced as a powerful contraceptive agent in preventing unplanned pregnancy and sexually transmitted infections (STIs) [2]. The limitation of applying these peptides is low stability in various environments (with different pH and temperatures) [3][4][5]. Different strategies have been developed to increase the metabolic stability of peptides, such as cyclization, substituting amides with sulfonamides, etc.…”

Section: Introductionmentioning

confidence: 99%

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Design of a New Coating Agent Based on Graphene Oxide and Antimicrobial/Spermicidal Peptide (Sarcotoxin Pd) for Condom Coating: New Strategy for Prevention of Unplanned Pregnancy and Sexually Transmitted Infections

Zare‐Zardini

Alemi²,

Zahedi

et al. 2023

Journal of Nanomaterials

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In this study, sarcotoxin Pd-functionalized graphene oxide (GO-Pd) was synthesized as a new condom-coating agent. Antimicrobial activity was evaluated by radial diffusion assay (RDA) and absorbance-based methods. Sperm motility and morphology were assessed in different concentrations of designed nanostructures. Peptide stability on the GO structures was assessed by the CD technique. GO-Pd showed the highest contact angle. The results approved that GO-Pd had broad-spectrum antimicrobial activities against examined pathogens, especially vaginal infections such as Candida vulvovaginitis. This antimicrobial activity was more than pristine peptides, vancomycin, and fluconazole. GO-Pd also had a higher inhibitory activity on the sperm motility and viability than pristine peptides. GO-Pd had high stability and activity in all examined conditions. But, naked peptides had low stability and activity after incubation in acidic pH and high temperatures (>38°C). In all tests, GO-Pd showed a significant difference compared to naked peptide. Based on the results, GO-Pd can be used as a condom coating to prevent unplanned pregnancy and sexually transmitted infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%