Antimicrobial Peptides as Effective Agents Against Drug-Resistant Pathogens

Tiwari, Pragya; Srivastava, Yashdeep; Kumar, Vinay

doi:10.1007/978-981-16-3120-7_11

Cited by 4 publications

(4 citation statements)

References 188 publications

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“…The rising frequency of antibiotic resistance and the emergence of drug-resistant diseases have a significant impact on developing countries’ economies [ 4 , 5 ], particularly those with limited healthcare facilities. The research initiatives have defined the ‘One Health and Global Health’ concept to address the critical themes in infectious diseases, particularly those contributing to AMR spread [ 6 , 7 , 8 ]. The interdisciplinary concept of ‘One Heath and Global Health’ provides knowledge-based information on the emergence of drug-resistant microbes and AMR evolution, the interconnected network of humans, animals, and the environment, and socio-economic factors in the spread of AMR [ 9 , 10 ].…”

Section: Overview Of Global Antibiotic Resistance and Drug Discoverymentioning

confidence: 99%

“…Substantial progress has been achieved the production of AMPs in plant systems via synthetic biology [45]. The co-integration synthetic biology strategies with system biology, genome engineering, and RNA interfe ence (RNAi) for plant chassis and process optimization has yielded significant results antimicrobial production [6,7], a plausible approach to addressing AMR. Through th thematic review, we herein present the recent trends in AMR prevalence and the prospec of AMPs as key arsenals to counter drug-resistant pathogens in a socio-economic contex In this direction, plants as production platforms and their genetic manipulation via syn thetic biology comprise a sustainable approach to the production of novel and potent an timicrobials (Figure 2).…”

Section: Overview Of Global Antibiotic Resistance and Drug Discoverymentioning

confidence: 99%

“…Table 1. Key examples of phytomolecules as potent antimicrobials, their bioactive constituents, and modes of action against pathogenic microbes (modified from Tiwari et al [7]).…”

Section: Natural Compounds and Derivatives As Potential Antimicrobial...mentioning

confidence: 99%

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Antimicrobial Peptides: The Production of Novel Peptide-Based Therapeutics in Plant Systems

Tiwari,

Srivastava,

Sharma

et al. 2023

Life

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The increased prevalence of antibiotic resistance is alarming and has a significant impact on the economies of emerging and underdeveloped nations. The redundancy of antibiotic discovery platforms (ADPs) and injudicious use of conventional antibiotics has severely impacted millions, across the globe. Potent antimicrobials from biological sources have been extensively explored as a ray of hope to counter the growing menace of antibiotic resistance in the population. Antimicrobial peptides (AMPs) are gaining momentum as powerful antimicrobial therapies to combat drug-resistant bacterial strains. The tremendous therapeutic potential of natural and synthesized AMPs as novel and potent antimicrobials is highlighted by their unique mode of action, as exemplified by multiple research initiatives. Recent advances and developments in antimicrobial discovery and research have increased our understanding of the structure, characteristics, and function of AMPs; nevertheless, knowledge gaps still need to be addressed before these therapeutic options can be fully exploited. This thematic article provides a comprehensive insight into the potential of AMPs as potent arsenals to counter drug-resistant pathogens, a historical overview and recent advances, and their efficient production in plants, defining novel upcoming trends in drug discovery and research. The advances in synthetic biology and plant-based expression systems for AMP production have defined new paradigms in the efficient production of potent antimicrobials in plant systems, a prospective approach to countering drug-resistant pathogens.

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Section: Overview Of Global Antibiotic Resistance and Drug Discoverymentioning

confidence: 99%

Section: Overview Of Global Antibiotic Resistance and Drug Discoverymentioning

confidence: 99%

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Antimicrobial Peptides: The Production of Novel Peptide-Based Therapeutics in Plant Systems

Tiwari,

Srivastava,

Sharma

et al. 2023

Life

Self Cite

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“…The coevolution of plants with their associated microbiomes has positively impacted both associates, with microbes assisting plants in dealing with environmental stresses, delineated as the ‘cry for help’ defense employed by the plants [ 9 , 10 ]. In case of any type of stress, including pest-induced, abiotic, or pathogen attacks affecting plants [ 10 , 11 ], the beneficial microbes are recruited to promote stress tolerance [ 12 , 13 , 14 ], and these plant–microbiome dynamics are crucial for nutrient acquisition [ 15 ] and plant development [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Trends in Harnessing Plant Endophytic Microbiome for Heavy Metal Mitigation in Plants: A Perspective

Tiwari

Bae

2023

Plants

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Plant microbiomes represent dynamic entities, influenced by the environmental stimuli and stresses in the surrounding conditions. Studies have suggested the benefits of commensal microbes in improving the overall fitness of plants, besides beneficial effects on plant adaptability and survival in challenging environmental conditions. The concept of ‘Defense biome’ has been proposed to include the plant-associated microbes that increase in response to plant stress and which need to be further explored for their role in plant fitness. Plant-associated endophytes are the emerging candidates, playing a pivotal role in plant growth, adaptability to challenging environmental conditions, and productivity, as well as showing tolerance to biotic and abiotic stresses. In this article, efforts have been made to discuss and understand the implications of stress-induced changes in plant endophytic microbiome, providing key insights into the effects of heavy metals on plant endophytic dynamics and how these beneficial microbes provide a prospective solution in the tolerance and mitigation of heavy metal in contaminated sites.

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Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens

Tiwari,

Thakkar,

Dufossé

2024

Critical Reviews in Biotechnology

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Antimicrobial Peptides as Effective Agents Against Drug-Resistant Pathogens

Cited by 4 publications

References 188 publications

Antimicrobial Peptides: The Production of Novel Peptide-Based Therapeutics in Plant Systems

Antimicrobial Peptides: The Production of Novel Peptide-Based Therapeutics in Plant Systems

Trends in Harnessing Plant Endophytic Microbiome for Heavy Metal Mitigation in Plants: A Perspective

Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens

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