Antimicrobial peptides are among the antagonistic metabolites produced by Bifidobacterium against Helicobacter pylori

Collado, María Carmen; González, Ana; Gonzalez, R. Gilberto; Cedillo-Hernandez, Manuel; Ferrús, María Antonia; Sanz, Yolanda

doi:10.1016/j.ijantimicag.2005.01.017

Cited by 97 publications

(60 citation statements)

References 24 publications

(25 reference statements)

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“…MIC values were higher for cefotaxime than for penicillin G. Cell wall impermeability seems to be the main cause of cephalosporin resistance among the bifidobacteria (29,37). Our finding suggests intrinsic resistance to metronidazole, much in line with previous reports (29,(37)(38)(39).…”

Section: Discussionsupporting

confidence: 91%

Bifidobacterium Bacteremia: Clinical Characteristics and a Genomic Approach To Assess Pathogenicity

et al. 2017

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Bifidobacteria are commensals that colonize the orogastrointestinal tract and rarely cause invasive human infections. However, an increasing number of bifidobacterial blood culture isolates has lately been observed in Norway. In order to investigate the pathogenicity of the Bifidobacterium species responsible for bacteremia, we studied Bifidobacterium isolates from 15 patients for whom cultures of blood obtained from 2013 to 2015 were positive. We collected clinical data and analyzed phenotypic and genotypic antibiotic susceptibility. All isolates (11 Bifidobacterium longum, 2 B. breve, and 2 B. animalis isolates) were subjected to whole-genome sequencing. The 15 patients were predominantly in the extreme lower or upper age spectrum, many were severely immunocompromised, and 11 of 15 had gastrointestinal tract-related conditions. In two elderly patients, the Bifidobacterium bacteremia caused a sepsis-like picture, interpreted as the cause of death. Most bifidobacterial isolates had low MICs (Յ0.5 mg/liter) to beta-lactam antibiotics, vancomycin, and clindamycin and relatively high MICs to ciprofloxacin and metronidazole. We performed a pangenomic comparison of invasive and noninvasive B. longum isolates based on 65 sequences available from GenBank and the sequences of 11 blood culture isolates from this study. Functional annotation identified unique genes among both invasive and noninvasive isolates of Bifidobacterium. Phylogenetic clusters of invasive isolates were identified for a subset of the B. longum subsp. longum isolates. However, there was no difference in the number of putative virulence genes between invasive and noninvasive isolates. In conclusion, Bifidobacterium has an invasive potential in the immunocompromised host and may cause a sepsis-like picture. Using comparative genomics, we could not delineate specific pathogenicity traits characterizing invasive isolates.KEYWORDS DNA sequencing, antibiotic resistance, bifidobacteria, blood culture, bloodstream infections, mass spectrometry, pangenome, probiotics, susceptibility testing, virulence factors B ifidobacteria are anaerobic, nonsporulating Gram-positive rods representing ubiquitous inhabitants of the human orogastrointestinal tract and vagina. The genus consists of more than 50 species, with only 10 species being found in humans. In breast-fed infants, bifidobacteria constitute more than 80% of the intestinal microbiota, whereas bifidobacteria comprise only 3 to 6% of the adult fecal flora (1, 2). Moreover, the species distribution is different in infants and adults; Bifidobacterium adolescentis and Bifidobacterium longum subsp. longum are the major bifidobacterial species in the

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Section: Discussionsupporting

confidence: 91%

Bifidobacterium Bacteremia: Clinical Characteristics and a Genomic Approach To Assess Pathogenicity

et al. 2017

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“…For commercial exploitation, bifidobacterial strains are typically se-lected for fast growth, antibacterial activity, good adhesion properties, and utilization of prebiotic substrates (151). Among the many probiotic features that have been attributed to bifidobacteria are (i) the induction of immunoglobulin production, (ii) improvement of a food's nutritional value by assimilation of substrates not metabolized by the host, (iii) anticarcinogenic activity, and (iv) folic acid synthesis (152)(153)(154). Some bifidobacteria produce antimicrobials (155) and notably, also bacteriocins (156,157).…”

Section: Figmentioning

confidence: 99%

Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka

Vatsa

Sanchez

et al. 2016

Microbiol Mol Biol Rev

1,450

1,048

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SUMMARYActinobacteriaare Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and terrestrial ecosystems. ManyActinobacteriahave a mycelial lifestyle and undergo complex morphological differentiation. They also have an extensive secondary metabolism and produce about two-thirds of all naturally derived antibiotics in current clinical use, as well as many anticancer, anthelmintic, and antifungal compounds. Consequently, these bacteria are of major importance for biotechnology, medicine, and agriculture.Actinobacteriaplay diverse roles in their associations with various higher organisms, since their members have adopted different lifestyles, and the phylum includes pathogens (notably, species ofCorynebacterium,Mycobacterium,Nocardia,Propionibacterium, andTropheryma), soil inhabitants (e.g.,MicromonosporaandStreptomycesspecies), plant commensals (e.g.,Frankiaspp.), and gastrointestinal commensals (Bifidobacteriumspp.).Actinobacteriaalso play an important role as symbionts and as pathogens in plant-associated microbial communities. This review presents an update on the biology of this important bacterial phylum.

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“…Firstly, the bacteriocins generated by lactobacillus exert an inhibition on H. pylori directly, and some other probiotic bacterium including bifidobacterium and enterococcus may also suppress the viability of H. pylori by producing heat stable proteinaceous compounds (33). Secondly, it is concerning the secreted metabolites especially lactic acid produced by lactobacillus suppressing urease activity of H. pylori (34,35).…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus -containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis

Zheng¹,

Lin²,

Mei³

2013

Rev. esp. enferm. dig.

101

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Background: Helicobacter pylori infection is recognized as a major contributory factor to many diseases, but recommended eradication therapies demonstrated unsatisfactory eradication rates. Currently, some studies suggested that lactobacillus species have an inhibitory action on Helicobacter pylori both in vitro and in vivo.Objective: this meta-analysis broadly examined the efficacy of eradication regimens supplemented with lactobacillus-containing probiotic on eradication rates and side effects.Methods: eligible articles were identified by comprehensive searches. Statistical analysis was performed with Review Manager 5.2. Outcomes were finally evaluated according to GRADE system.Results: nine randomized controlled trials of high-quality met eligible criteria. Risk ratio of eradication was available for 1,163 patients. Lactobacillus-containing probiotics significantly increased the eradication rate compared with the control group based upon intention-to-treat analysis [RR = 1.14; 95 %CI (1.06-1.22); number needed to treat (NNT) = 10] by the fixed effect model without significant publication bias, but no significant reduction associated with overall side effects was observed [RR = 0.88;]. In the subgroup analysis, eradication rates raised significantly by 17 % in lactobacillus administrated alone group [RR = 1.25; 95 %CI (1.13-1.37); NNT = 6]. In multistrain probiotics group, eradication rates enhanced only 2.8 % [RR = 1.04; 95 %CI (0.94-1.14)]. It also showed that lactobacillus-containing probiotics improved the eradication rates, respectively, both in adults [RR = 1.12; Conclusions: Lactobacillus-containing probiotic as an adjunct is effective to eradication therapy, while side effects caused by eradication treatment may not decrease. Furthermore, lactobacillus administrated alone will distinctly benefit eradication therapy.

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Antimicrobial peptides are among the antagonistic metabolites produced by Bifidobacterium against Helicobacter pylori

Cited by 97 publications

References 24 publications

Bifidobacterium Bacteremia: Clinical Characteristics and a Genomic Approach To Assess Pathogenicity

Bifidobacterium Bacteremia: Clinical Characteristics and a Genomic Approach To Assess Pathogenicity

Taxonomy, Physiology, and Natural Products of Actinobacteria

Lactobacillus -containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis

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