Antimicrobial Peptides and Peptidomimetics for the Control of Antimicrobial Resistance

Weeks, Richard; Algburi, Ammar; Chikindas, Michael L.

doi:10.1007/978-3-030-58259-3_7

Search citation statements

Order By: Relevance

Paper Sections

Select...

Next Generation Peptidomimetic Antibacterial1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2023

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 213 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high molecular weight, lesser yield with increased production cost and their biological instability have limited the commercial usefulness of HDPs. [22] These challenges are overcome by the advent of synthetic small peptidomimetics (SPMs) which possess the essential pharmacophore of natural HDPs having the intact biological activity with more stability and less degradation. [23] The recent research is focused on improving the biological efficacy better than the naturally occurring HDPs.…”

Section: Next Generation Peptidomimetic Antibacterialmentioning

confidence: 99%

A Prospective Diversity of Antibacterial Small Peptidomimetic and Quorum Sensing Mediated Drug: A Review

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Next Generation Peptidomimetic Antibacterialmentioning

confidence: 99%

A Prospective Diversity of Antibacterial Small Peptidomimetic and Quorum Sensing Mediated Drug: A Review

et al. 2022

View full text Add to dashboard Cite

show abstract

Synthesis of adenine-based cationic and anionic amphiphiles

Singh

2023

Chem. Pap.

View full text Add to dashboard Cite

Efficacy of Natural Antimicrobial Peptides Versus Peptidomimetic Analogues: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

Aims: This systematic review was carried out to determine whether synthetic peptidomimetics exhibit significant advantages over antimicrobial peptides (AMPs) in terms of in vitro potency. Structural features – molecular weight, charge and length – were examined for correlations with activity. Methods: Original research articles reporting minimum inhibitory concentration (MIC) values against Escherichia coli, indexed until 31 December 2020, were searched in PubMed/ScienceDirect/Google Scholar and evaluated using mixed-effects models. Results: In vitro antimicrobial activity of peptidomimetics resembled that of AMPs. Net charge significantly affected MIC values (p < 0.001) with a trend of 4.6% decrease for increments in charge by +1. Conclusion: AMPs and antibacterial peptidomimetics exhibit similar potencies, providing an opportunity to exploit the advantageous stability and bioavailability typically associated with peptidomimetics.

show abstract

Antimicrobial Peptides and Peptidomimetics for the Control of Antimicrobial Resistance

Cited by 3 publications

References 213 publications

A Prospective Diversity of Antibacterial Small Peptidomimetic and Quorum Sensing Mediated Drug: A Review

A Prospective Diversity of Antibacterial Small Peptidomimetic and Quorum Sensing Mediated Drug: A Review

Synthesis of adenine-based cationic and anionic amphiphiles

Efficacy of Natural Antimicrobial Peptides Versus Peptidomimetic Analogues: A Systematic Review

Contact Info

Product

Resources

About