Antimicrobial minimum inhibitory concentration of Mycoplasma gallisepticum: a systematic review

Taiyari, H.; Faiz, Nik M.; Abu, Jalila; Zakaria, Zunita

doi:10.1016/j.japr.2021.100160

Cited by 6 publications

(10 citation statements)

References 44 publications

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“…Antibacterial resistance in M. gallisepticum has been increasing and is primarily the result of irrational antibiotic use and abuse ( 22 , 23 ). To solve these types of problems, Zhao and Drlica proposed the “mutant selection window” (MSW) hypothesis that a drug concentration zone exists in which resistant mutants are selectively amplified and this generates reduced drug susceptibility ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic and Pharmacodynamic integration of tilmicosin against Mycoplasma gallisepticum in the target infection site in chickens

Zhang

Zhou²,

Yan³

et al. 2022

Front. Vet. Sci.

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Mycoplasma gallisepticum (M. gallisepticum) is a primary respiratory pathogen of poultry and causes significant economic losses to the poultry industry. There were no reported articles concerning the Pharmacokinetics/Pharmacodynamics (PK/PD) interactions of tilmicosin against M. gallisepticum in vivo. In the current study, we established an in vivo M. gallisepticum infection model and tilmicosin was administered orally to the M. gallisepticum-infected chickens by different dosage regimens. The concentration of tilmicosin in lung tissue was determined by high-pressure liquid chromatography/tandem mass spectrometry (HPLC–MS/MS), besides the counting of the viable colony of M. gallisepticum in lung tissue was also monitored dynamically to appraise the PK/PD interactions of tilmicosin against M. gallisepticum. We found that anti-mycoplasmal activity was concentration-dependent and mycoplasmacidal activity was observed at tilmicosin dosage >7.5 mg/kg. The PK/PD parameter of AUC/MIC (The area under the concentration–time curve divided by the minimal inhibitory concentration) correlated well with anti-mycoplasmal efficacy (R2 = 0.92). The ratios of AUC/MIC for 1 log10 and 3 log10 colony-forming units [CFU]/lung reductions were 300.02 and 6,950.15 h, respectively. These findings indicated that tilmicosin may be therapeutically effective in chickens to treat M. gallisepticum lung infections if administered at a dose of 9.12 mg/kg.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetic and Pharmacodynamic integration of tilmicosin against Mycoplasma gallisepticum in the target infection site in chickens

Zhang

Zhou²,

Yan³

et al. 2022

Front. Vet. Sci.

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“…Therefore, the authors preferred to indicate the MIC values as low, intermediate or high, minimizing the use of the terms “sensitive”, “intermediate”, and “resistant”. As also recommended by Taiyari and collaborators [ 21 ], MIC tests were carried out by following the recommended procedure present in the literature [ 22 ]. In this way, our data can be compared with many of those previously published and therefore be potentially useful for scientists, veterinarians, and poultry industry specialists living in other parts of the world.…”

Section: Discussionmentioning

confidence: 99%

“…The Italian Mg sample distribution along the drug dilutions on the x -axis (see Table 1 and Figure S1 ) possibly indicates the absence of resistance selection towards these molecules except for six strains that showed high oxytetracycline MIC values (≥32 µg/mL). A recent review of the data presented in 23 studies investigating the MIC values of Mg obtained in 17 countries around the world [ 21 ] evidenced that 47% of the Mg strains tested were resistant to oxytetracycline. The tetracyclines are amphoteric compounds that are not readily accumulated in eukaryotic cells, in which Mg is able to enter and “hide” [ 23 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, most (79.1%) of the Italian Mg sample showed enrofloxacin MICs ≥ 8 µg/mL, and both MIC50 and MIC90 values were higher than the highest drug dilution tested on plate (>16 µg/mL). In the literature, it is reported that enrofloxacin is the molecule toward which resistance has been detected with highest frequency in Mg isolates that were collected between 1993 and 2018 in different countries of the world [ 21 ]. Mg isolates collected in different geographical locations before 1997 showed low MIC50 (0.05 µg/mL) and MIC90 (0.1 µg/mL) values for enrofloxacin [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

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The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin

et al. 2022

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Mycoplasma gallisepticum (Mg) is a highly contagious avian pathogen responsible for significant economic losses for the poultry industry. In some circumstances, antimicrobial treatment is useful to contain clinical signs of Mg infection in birds. However, antimicrobial resistance emergence is now common among animal pathogens, becoming a worldwide health concern. The collection of minimum inhibitory concentration (MIC) data is fundamental for an appropriate antimicrobial use and for fighting antimicrobial resistance emergence. However, MIC data can only be generated in specialized laboratories, and therefore they are not regularly available. MICs of 67 non-vaccine-derived Mg isolates collected in Italy between 2010 and 2020 were obtained. Although 79.1% of the Mg isolates showed enrofloxacin MICs ≥8 µg/mL, a statistically significant trend toward low MICs of erythromycin, tylosin, tilmicosin, spiramycin, tiamulin, and lincomycin was observed, indicating a comeback to susceptibility of Mg toward these drugs. Doxycycline proved to be slightly more effective than oxytetracycline. The present study shows that Mg changed its susceptibility toward many of the drugs most commonly used for its containment over a ten-year period.

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“…Unfortunately, this approach cannot eradicate disease from an infected flock and the issue of antimicrobial resistance (AMR) has become increasingly prevalent. In particular, resistance to enrofloxacin, tylosin and oxytetracycline has now developed across a wide range of geographical regions and in a variety of poultry species [40].…”

Section: Antibiotic Therapymentioning

confidence: 99%

The Ring-Necked Pheasant (Phasianus colchicus) Industry within the United Kingdom and the Threat Posed by Mycoplasma gallisepticum: A Review

Balfour

2022

Veterinary Sciences

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In ring-necked pheasants (Phasianus colchicus), Mycoplasma gallisepticum (MG) infection is frequently associated with infectious sinusitis. This condition causes swelling of the infraorbital sinuses, upper respiratory distress, depression and variable levels of mortality, and is considered one of the most important clinical and economic diseases of pheasants. This review provides a brief overview of the structure of the UK pheasant industry, with reference to the various stages within the supply chain, common diseases and challenges facing the industry. The current understanding of MG transmission, prevalence, clinical expression, diagnosis and control strategies in pheasants is subsequently summarised. In addition, this review aims to assess the current gaps in knowledge relating specifically to MG in pheasants, with reference and extrapolation where appropriate to data gathered from other species.

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Antimicrobial minimum inhibitory concentration of Mycoplasma gallisepticum: a systematic review

Cited by 6 publications

References 44 publications

Pharmacokinetic and Pharmacodynamic integration of tilmicosin against Mycoplasma gallisepticum in the target infection site in chickens

Pharmacokinetic and Pharmacodynamic integration of tilmicosin against Mycoplasma gallisepticum in the target infection site in chickens

The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin

The Ring-Necked Pheasant (Phasianus colchicus) Industry within the United Kingdom and the Threat Posed by Mycoplasma gallisepticum: A Review

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