Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides

Li, Xin; Zuo, Siyao; Wang, Bin; Zhang, Kaiyu; Wang, Yang

doi:10.3390/molecules27092675

Cited by 64 publications

(100 citation statements)

References 242 publications

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“…Due to the increasing resistance of viruses and the limited effect of common drugs, antiviral peptides play an essential role as therapeutic agents [ 43 ]. AMPs with antiviral activity are referred to as antiviral peptides (AVPs) [ 53 , 54 ]. There are several different mechanisms by which antiviral peptides block viruses at various stages of their cycle [ 34 ].…”

Section: Antimicrobial Effects Of Ampsmentioning

confidence: 99%

“…The target site of AVPs can be DNA and RNA [ 62 , 63 ], and the goal of their action is to destroy the viral envelope, leading to its instability, as in the Junin virus (JV), HIV-1, and HSV-2 [ 64 ]. Another way to inhibit viruses is to modify or interfere with cell signaling pathways [ 65 ], such as GF-17 (17-mer-derived peptide from human cathelicidin LL-37) and BMAP-18 (bovine myeloid antimicrobial peptide-18), which can inactivate the Zika virus (ZIKV) by interfering with interferon type 1 signaling [ 54 ]. Recently, there has been an increasing number of studies on the antiviral effect of AVPs on coronaviruses (such as SARS-CoV).…”

Section: Antimicrobial Effects Of Ampsmentioning

confidence: 99%

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Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications

et al. 2022

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The growing emergence of antimicrobial resistance represents a global problem that not only influences healthcare systems but also has grave implications for political and economic processes. As the discovery of novel antimicrobial agents is lagging, one of the solutions is innovative therapeutic options that would expand our armamentarium against this hazard. Compounds of interest in many such studies are antimicrobial peptides (AMPs), which actually represent the host’s first line of defense against pathogens and are involved in innate immunity. They have a broad range of antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, and viruses, with specific mechanisms of action utilized by different AMPs. Coupled with a lower propensity for resistance development, it is becoming clear that AMPs can be seen as emerging and very promising candidates for more pervasive usage in the treatment of infectious diseases. However, their use in quotidian clinical practice is not without challenges. In this review, we aimed to summarize state-of-the-art evidence on the structure and mechanisms of action of AMPs, as well as to provide detailed information on their antimicrobial activity. We also aimed to present contemporary evidence of clinical trials and application of AMPs and highlight their use beyond infectious diseases and potential challenges that may arise with their increasing availability.

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Section: Antimicrobial Effects Of Ampsmentioning

confidence: 99%

Section: Antimicrobial Effects Of Ampsmentioning

confidence: 99%

Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications

et al. 2022

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“…They are short peptides that, in most cases, show high specificity towards pathogens with minimal toxicity to the host. These features make AMPs good candidates for drug development [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV

Marcocci

Jackowska

Prezioso

et al. 2022

IJMS

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Herpes simplex virus type-1 (HSV-1) and John Cunningham polyomavirus (JCPyV) are widely distributed DNA viruses causing mainly asymptomatic infection, but also mild to very severe diseases, especially when these viruses reach the brain. Some drugs have been developed to inhibit HSV-1 replication in host cells, but their prolonged use may induce resistance phenomena. In contrast, to date, there is no cure for JCPyV. The search for alternative drugs that can reduce viral infections without undermining the host cell is moving toward antimicrobial peptides (AMPs) of natural occurrence. These include amphibian AMPs belonging to the temporin family. Herein, we focus on temporin G (TG), showing that it strongly affects HSV-1 replication by acting either during the earliest stages of its life cycle or directly on the virion. Computational studies have revealed the ability of TG to interact with HSV-1 glycoprotein B. We also found that TG reduced JCPyV infection, probably affecting both the earliest phases of its life cycle and the viral particle, likely through an interaction with the viral capsid protein VP1. Overall, our results are promising for the development of short naturally occurring peptides as antiviral agents used to counteract diseases related to HSV-1 and JCPyV.

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“…This advantage provides a prerequisite for the development of AMPs as therapeutic agents. Previous studies have shown that AMPs can not only directly act on cell membranes and cell walls to kill cells, but can also enter cells and target organelles to achieve bactericidal effects by interfering with normal metabolic processes and playing an immunomodulatory role [ 5 , 6 , 7 ]. Many AMP drugs have been developed for clinical treatment, such as lipopeptide A21978C for the treatment of skin infection and sepsis and peptide Glutoxim/NOV-002 for the treatment of tuberculosis and non-small-cell lung cancer [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability

Wang

Zhang

et al. 2022

IJMS

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Changes in mitochondrial membrane permeability are closely associated with mitochondria-mediated apoptosis. Antimicrobial peptides (AMPs), which have been found to enter cells to exert physiological effects, cause damage to the mitochondria. This paper reviews the molecular mechanisms of AMP-mediated apoptosis by changing the permeability of the mitochondrial membrane through three pathways: the outer mitochondrial membrane (OMM), inner mitochondrial membrane (IMM), and mitochondrial permeability transition pore (MPTP). The roles of AMPs in inducing changes in membrane permeability and apoptosis are also discussed. Combined with recent research results, the possible application prospects of AMPs are proposed to provide a theoretical reference for the development of AMPs as therapeutic agents for human diseases.

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Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides

Cited by 64 publications

References 242 publications

Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications

Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications

The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV

Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability

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