Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea

Cao, Duc Danh; Trinh, Thi Thanh Van; Thi, Huong Doan; Vu, Van Nam; Le, Hong Minh; Thi, Quyen Vu; Nguyễn, Mai Ánh; Duong, T.; Tran, Dang Thach; Chau, Van Minh; Ma, Rui; Shetye, Gauri; Cho, Sang Hyun; Murphy, Brian T.; Pham, Van Cuong

doi:10.3390/md17090529

Cited by 19 publications

(23 citation statements)

References 33 publications

(30 reference statements)

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“…Another recent example was the elucidation of three new flavonoids from sponge-derived Streptomyces sp. with antimicrobial activity [ 37 ]. Likewise, most anticancer (i.e., cancer-preventive, antitumor, cytotoxic) molecules produced by sponge-bacteria associations are derived from Proteobacteria (γ-Proteobacteria), Actinobacteria, and Firmicutes [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria

et al. 2021

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Marine sponges harbor diverse microbial communities that represent a significant source of natural products. In the present study, extracts of 21 sponge-associated bacteria were screened for their antimicrobial and anticancer activity, and their genomes were mined for secondary metabolite biosynthetic gene clusters (BGCs). Phylogenetic analysis assigned the strains to four major phyla in the sponge microbiome, namely Proteobacteria, Actinobacteria, Bacteroidetes, and Firmicutes. Bioassays identified one extract with anti-methicillin-resistant Staphylococcus aureus (MRSA) activity, and more than 70% of the total extracts had a moderate to high cytotoxicity. The most active extracts were derived from the Proteobacteria and Actinobacteria, prominent for producing bioactive substances. The strong bioactivity potential of the aforementioned strains was also evident in the abundance of BGCs, which encoded mainly beta-lactones, bacteriocins, non-ribosomal peptide synthetases (NRPS), terpenes, and siderophores. Gene-trait matching was performed for the most active strains, aiming at linking their biosynthetic potential with the experimental results. Genetic associations were established for the anti-MRSA and cytotoxic phenotypes based on the similarity of the detected BGCs with BGCs encoding natural products with known bioactivity. Overall, our study highlights the significance of combining in vitro and in silico approaches in the search of novel natural products of pharmaceutical interest.

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Section: Introductionmentioning

confidence: 99%

Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria

et al. 2021

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“…nov., from a marine sponge with antibacterial potential against Streptococcus agalactiae [45]. Other researchers have isolated new compounds from Streptomyces associated with marine sponges in the Vietnam Sea, some of which are completely novel compounds active against both Gram-positive and Gram-negative bacteria and Mycobacterium tuberculosis [46]. Under certain conditions, these new bioactive compounds can also inhibit bacterial biofilm formation [47].…”

Section: Spongesmentioning

confidence: 99%

Streptomyces from traditional medicine: sources of new innovations in antibiotic discovery

Quinn

Banat

Abdelhameed

et al. 2020

Journal of Medical Microbiology

130

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Given the increased reporting of multi-resistant bacteria and the shortage of newly approved medicines, researchers have been looking towards extreme and unusual environments as a new source of antibiotics. Streptomyces currently provides many of the world’s clinical antibiotics, so it comes as no surprise that these bacteria have recently been isolated from traditional medicine. Given the wide array of traditional medicines, it is hoped that these discoveries can provide the much sought after core structure diversity that will be required of a new generation of antibiotics. This review discusses the contribution of Streptomyces to antibiotics and the potential of newly discovered species in traditional medicine. We also explore how knowledge of traditional medicines can aid current initiatives in sourcing new and chemically diverse antibiotics.

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“…G248. Compounds 77-79 showed remarkable antimicrobial activity, and compounds 80 and 81 were found to inhibit Mycobacterium tuberculosis H37Rv with the MIC values of 6.0 and 11.1 µg/mL [61]. A strain of Penicillium griseoroseum was isolated from Coffeea arabica seeds, and its metabolites were studied in 5,7,3 ,4 ,5 -pentamethoxyflavanone supplemented medium to obtain bezylated flavanone (82) [62].…”

Section: Flavonoid Glycosidesmentioning

confidence: 99%

Naturally Occurring Flavonoids and Isoflavonoids and Their Microbial Transformation: A Review

et al. 2020

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Flavonoids and isoflavonoids are polyphenolic secondary metabolites usually produced by plants adapting to changing ecological environments over a long period of time. Therefore, their biosynthesis pathways are considered as the most distinctive natural product pathway in plants. Seemingly, the flavonoids and isoflavones from fungi and actinomycetes have been relatively overlooked. In this review, we summarized and classified the isoflavones and flavonoids derived from fungi and actinomycetes and described their biological activities. Increasing attention has been paid to bioactive substances derived from microorganism whole-cell biotransformation. Additionally, we described the utilization of isoflavones and flavonoids as substrates by fungi and actinomycetes for biotransformation through hydroxylation, methylation, halogenation, glycosylation, dehydrogenation, cyclisation, and hydrogenation reactions to obtain rare and highly active biofunctional derivatives. Overall, among all microorganisms, actinomycetes are the main producers of flavonoids. In our review, we also summarized the functional genes involved in flavonoid biosynthesis.

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Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea

Cited by 19 publications

References 33 publications

Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria

Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria

Streptomyces from traditional medicine: sources of new innovations in antibiotic discovery

Naturally Occurring Flavonoids and Isoflavonoids and Their Microbial Transformation: A Review

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