Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

Caló, Enrica; Barros, João M.S. de; Fernández-Gutiérrez, Mar; Román, Julio San; Ballamy, Lucy; Khutoryanskiy, Vitaliy V.

doi:10.1039/c6ra08234c

Cited by 39 publications

(37 citation statements)

References 41 publications

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“…T5 has a higher crosslinking degree than T3, and consequently, it has lower free acid groups to take part in the adhesion process. The obtained results suggest that the adhesion forces are higher than the ones obtained by Calo et al for a similar type of hydrogels (Calo, et al 2016b).…”

Section: Tween 85-based Hydrogels As Oral Drug Delivery Systemsmentioning

confidence: 43%

“…FTIR measurements (Figure 3) and the swelling of the resulting hydrogels (Figure 1) confirmed the crosslinking reaction. A similar procedure has been used before to prepare GAN hydrogels, however these materials were used mainly for the delivery of hydrophilic drugs as the selected crosslinkers were PEG or poly(vinyl alcohol) (Calo, et al 2016b;Raj Singh, et al 2010).…”

Section: Discussionmentioning

confidence: 99%

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Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 for sustained delivery of hydrophobic drugs

Larrañeta

Barturen

Ervine

et al. 2018

International Journal of Pharmaceutics

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Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 were prepared for hydrophobic drug delivery. The hydrogels were synthesized following a simple procedure carried out in solid state. The process did not require the use of any solvent and, as it is based on an esterification reaction, no toxic by-products were obtained. The resulting hydrogels contained Tween 85 inside the structure and due to the amphiphilic nature of this compound, hydrophobic domains within the hydrogel structure were formed. The obtained hydrogels showed good swelling capacities ranging from 100% to 600%. The esterification reaction that took place between poly(methyl vinyl ether-co-maleic acid) and Tween 85 was confirmed by infrared spectroscopy. Hydrogels were loaded with a hydrophobic drug model, Curcumin (CUR), showing that the hydrogels were able to retain up to 36 mg of CUR per g of hydrogel. Additionally, the synthesized hydrogels provided in vitro sustained CUR release over periods of up to 30 days. Finally, and due to the mucoadhesive nature of the prepared materials, one of the hydrogels was tested in vitro as an oral drug delivery system. For this purpose, the selected material was milled into microparticles (45-90 µm diameter). The release of CUR from the microparticles was evaluated under simulated gastric and intestinal conditions. The microparticles were able to release their cargos in 7 h. However, further work is required to optimize this system for oral drug delivery applications.

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Section: Tween 85-based Hydrogels As Oral Drug Delivery Systemsmentioning

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 for sustained delivery of hydrophobic drugs

Larrañeta

Barturen

Ervine

et al. 2018

International Journal of Pharmaceutics

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“…This indicates that the carbonyl carbon in the PT reacted with the hydroxyl group of the HA to form methyl vinyl ether unit (C-O-C), which had a stretching vibration peak at around 1100-1300 cm −1 . The C=C group stretch in the range of 1600-1680 cm −1 indicates that the unsaturated alkene bond of the PT was not destroyed in the cross-linked HA5-PT20 hydrogel film [14,15]. Therefore, a possible cross-linking mechanism would be the formation of an ester bond (C-O-C) between the hydroxyl group of the HA and the carbonyl carbon of the PT.…”

Section: Ftir Spectral Analysismentioning

confidence: 99%

Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid

2019

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Hyaluronic acid (HA) is a natural polysaccharide with promising applications in modern cosmetic and nutricosmetic products due to its high-water affinity, which is essential for skin hydration, as well as its biocompatibility, biodegradability, non-toxicity, and non-immunogenic nature. In this study, we investigated and optimized the method of crosslinking for formulating novel HA hydrogel films. We used Pentaerythritol Tetra-acrylate (PT) as the cross-linking agent over a range of pH values and used different cross-linking methods (Ultraviolet (UV) radiation, microwaving, and oven heating). The efficacy of the cross-linking reaction was evaluated using swelling studies and Fourier transform infrared (FTIR) spectroscopy for the characterization of the xerogel HA-PT film formulations. We found that HA-PT cross-linked hydrogels are produced under alkaline conditions (pH 11) but not under neutral or acidic conditions. Cross-linked HA-PT xerogel films using UV-irradiation showed excessive swelling indicative of inadequate cross-linking. The oven and microwaving methods produced HA-PT films with high cross-linking density. FTIR data suggest formation of ester bond between the carbonyl of the HA and hydroxyl group of the PT acrylate group. Overall, the oven method was considered better and easier than UV-radiation/microwave methods because it is safer, user-friendly and eco-friendly, and can process larger batches.

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“…41 Due to the high degree of physical cross-linking achieved using the freezethawing technique, their swelling ratio (SR) values are substantially lower than reported for chemically-crosslinked autoclaved hydrogels made from the same combination of polymers. 42 In fact, these hydrogels can absorb more than 40 g of deionized water per 1 g of initial gel within 48 h. However, the water uptake of the cryogels is reduced in the ionic solution for the presence of mobile ions in the medium. This reduction in the cryogels swelling is related to their polyelectrolyte nature and the charge screening effects in the presence of inorganic ions.…”

Section: Swelling Studiesmentioning

confidence: 99%

Poly(vinyl alcohol)–Gantrez® AN cryogels for wound care applications

et al. 2016

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Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

Abstract: Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride).

Cited by 39 publications

References 41 publications

Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 for sustained delivery of hydrophobic drugs

Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 for sustained delivery of hydrophobic drugs

Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid

Poly(vinyl alcohol)–Gantrez® AN cryogels for wound care applications

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