Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles

Abstract

Bacterial resistance to the treatment of infectious diseases is the main problem. Many classes of antibiotics are facing resistance and have initiated new efforts to develop new derivatives and discover new chemical classes. 1 Gram positive and gram-negative bacteria such as Escherichia coli, Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Pseudomonas aeruginosa etc. are responsible for many diverse infections which even can cause of death. 2 Thiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. Recently, third generation cefepime, ceftriaxone, cefix-ABSTRACT Thiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine thiazole derivatives which were thought to show antimicrobial activity. Synthesize were realized with good yield using the method which reports the anticholinesterase properties of these compounds. Similar compounds with the same scaffold (2, 4, 5 trisubstituted thiazoles) are investigated for antimicrobial activity. Compounds 23-27 exhibited MIC: 256 µM against S. aureus ATCC 25923. Besides, 27-33 group showed MIC: 256 µM against K. pneumoniae UC57 and B. cereus. It is remarkable that the compound 27 showed antimicrobial activity against 4 different microorganisms and 26 showed antimicrobial activity against L. monocytogenes by MIC: 32 µM which is same as the standart chloramphenicol.

Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs

“…FRAP test was performed with the method of Benzie and Strain's (1996) Experiments were performed in triplicate [25,26].…”