Antimicrobial evaluation and action mechanism of chalcone derivatives containing quinoxaline moiety

Synthesis of novel antibacterial and antifungal quinoxaline derivatives

“…However, few studies have been done on quinoxoline derivatives with strong antibacterial and antifungal activities. 29 Therefore, the study of quinoxaline derivatives as antibacterial and antifungal agents has an important significance for the diversification of pesticide development.…”

Scope of Tetrazolo[1,5-a]quinoxalines in CuAAC reactions for the Synthesis of Triazoloquinoxalines, Imidazoloquinoxalines, and Rhenium-complexes thereof

“…Quinoxalines are amongst the most versatile N-heterocyclic compounds, combining a straightforward synthesis with a diverse set of possible functionalizations and a wide range of applications in drug development and materials sciences. [1] Different quinoxaline derivatives possess antibacterial [2], antifungal [3], and antiviral properties [4] and form the core structure of commercially available drugs like Brimonidine, Varenicline, and Quinacillin. [5] Quinoxalines can also be used in organic solar cell polymers [1,6] and have been described as donor moieties in many TADF and OLED compounds.…”

“…[7][8][9] Amongst many other possible ways to modify and extend the core structure of quinoxalines, the conversion of tetrazolo [1,5-a]quinoxalines offers several advantages, as tetrazolo [1,5-a]quinoxalines can be used as quinoxaline-azide precursor, serving as a precursor for new nitrogen-enriched quinoxaline-based structures. Literature-known procedures for such a quinoxaline modification starting from tetrazolo [1,5-a]quinoxalines 1 are the synthesis of 1,2,3-triazoloquinoxalines (3) via copper-catalyzed azide-alkyne cycloaddition (CuAAC) [10] and the synthesis of imidazo[1,2-a]quinoxalines (2), which was recently reported for the first time using tetraphenylporphyrin iron(III) chloride as a catalyst. [11] While the target compounds, 1,2,3-triazoloquinoxalines (3) and imidazo [1,2-a]quinoxalines (2), offer a wide range of possible applications, the current knowledge on their formation from tetrazolo [1,5-a]quinoxalines 1 is still limited.…”

“…Literature-known procedures for such a quinoxaline modification starting from tetrazolo [1,5-a]quinoxalines 1 are the synthesis of 1,2,3-triazoloquinoxalines (3) via copper-catalyzed azide-alkyne cycloaddition (CuAAC) [10] and the synthesis of imidazo[1,2-a]quinoxalines (2), which was recently reported for the first time using tetraphenylporphyrin iron(III) chloride as a catalyst. [11] While the target compounds, 1,2,3-triazoloquinoxalines (3) and imidazo [1,2-a]quinoxalines (2), offer a wide range of possible applications, the current knowledge on their formation from tetrazolo [1,5-a]quinoxalines 1 is still limited. Triazole-linked Nheterocycles like pyridotriazoles and quinolinotriazoles exert a variety of favorable biological properties like anticancer and antimicrobial activities as well as protein kinase inhibition.…”

A newly synthesized nitrogen‐rich derivative of bicyclic quinoxaline—Structural and conceptual DFT reactivity study

“…Notably, these N‐heterocycles play an interesting role as basic skeleton for the synthesis of many other pharmacologically and biologically active agents. A large number of synthetic quinoxalines have been reported to exhibit Ant amoebic, anticancer, antifungal, antiviral and antibacterial, antimicrobial, antitumoral, anticonvulsant, antidiabetic, antinomic, antioxidant, antitubercular, and antileptospiral agents and neuroprotective activity . Also, some quinoxalines were used in agricultural field as pesticides and chemical controllable switches, corrosion inhibitor, and insecticides .…”