Antimicrobial Efficiency of Essential Oils from Traditional Medicinal Plants of Asir Region, Saudi Arabia over Drug Resistant Isolates

Helal, Ismail M.; Elbessoumy, Ashraf A; Al-Bataineh, Erwah; Joseph, Martin R.P.; Rajagopalan, Parassena; Chandramoorthy, Harish C.; Ahmed, Sami Ben Hadj

doi:10.20944/preprints201810.0236.v1

Cited by 10 publications

(12 citation statements)

References 13 publications

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“…In the same context, the Table 3, Table 4 and Table 5 show that the MFC results of the studied extracts show high antifungal activity (MFC) against the studied Candida albicans for chloroform and ethyl acetate extracts (21 ± 0.8 and 18 ± 0.6 mm inhibition zone diameter, respectively) and low antifungal activity of methanolic extract (10 ± 0.4 mm inhibition zone diameter) comparing to the standard luconazole antibiotics (20 mm inhibition zone diameter). It agrees with (Helal, 2019) who reported that methanolic extract of P. undulata showing antifungal activity for some fungal strains, for example, C. Albicans 20 mm diameter of inhibition zone and the highest activity toward M. boulardii about 32 mm.…”

Section: Minimum Inhibitory Concentration (Mic) Minimum Bactericidalsupporting

confidence: 92%

Antitumor, Antimicrobial activities and Phytochemicals Constituent of different Extracts of Pulicaria undulata (Forssk.) Oliver. Grown Naturally in Saudi Arabia

Alshehr

Ghobashy

2020

ijrps

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Antitumor and antimicrobial resistance are a habitual global issue, which continually demands finding new natural compounds to encounter the resistance. Pulicaria undulata (Forssk.) Oliver. (Asteraceae family) has numerous promising medicinal properties. The recent work aimed at determination of antitumor effects of three extracts of P. undulata on three types of human carcinoma; HEPG-2 hepatocellular carcinoma, MCF-7 breast carcinoma and HCT-116 colon carcinoma cell lines. Anticancer activity was assessed through studying the viability of the cancer cells and apoptotic pathway. Also, antimicrobial potency of different extracts was assessed against studied human pathogens (five Gram negative bacteria, two Gram positive bacteria and yeast). The results reveal that chloroform extract has different levels of cytotoxicity toward the three types of cancer cell lines. A considerable decline in cancer cell rates has been linked to increasing in concentration of plant extract. The half maximal inhibitory concentration IC 50 value was 3.01 µg/ mL for the HepG-2, 16.4 µg/mL for the MCF-7, and 7.4 µg/ mL for HCT-116. Followed by the ethyl acetate extract which showed strong cytotoxic activity against HEPG2 with IC 50 = 12.2 µg ∕ml and moderate activities against MCF7 and HCT 116 and recorded (IC 50 = 26.7 and 26.4 µg ∕ml, respectively). While the crude methanol extract recorded the lowest cytotoxic effect against HEPG2, MCF7 and HCT 116 with (IC 50 = 51.4, 105.1 and 86.7 µg ∕ ml, respectively). Chloroform and ethyl acetate extracts have a high antimicrobial activity more than methanol extract against the pathogens being studied. HPLC and GCMs Analysis identified numerous chemical compounds of P. undulata extracts with various therapeutic benefits. In conclusion, P. undulata has the potential to act as an antimicrobial agent against various pathogenic microbes and is a promising wild herb for the treatment of cancer.

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Section: Minimum Inhibitory Concentration (Mic) Minimum Bactericidalsupporting

confidence: 92%

Antitumor, Antimicrobial activities and Phytochemicals Constituent of different Extracts of Pulicaria undulata (Forssk.) Oliver. Grown Naturally in Saudi Arabia

Alshehr

Ghobashy

2020

ijrps

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“…Antimicrobial resistance is a global problem, and requires new antimicrobial drugs to challenge the resistance (19). This research confirmed antibacterial activity of the O. compactum EO, which has already been studied (16).…”

Section: Discussionsupporting

confidence: 76%

Antibacterial activity of Origanum compactum essential oil tested on vaginal and cervical clinical bacterial strains

Ibišević¹,

Husejnagić²,

Kazanović³

et al. 2019

Acta fac medic Naissensis

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Origanum compactum (O. compactum) is an endemic Moroccan medicinal herb. Numerous studies have shown that O. compactum organic extracts, essential oil and its main components possess a broader spectrum of pharmacological and therapeutic activities such as antibacterial, antifungal, antioxidant and antitumour activity. This research was designed to examine the antibacterial activity of O. compactum essential oil tested on clinical bacterial strains isolated from vaginal and cervical swabs. First, antibacterial activity was tested against standard bacterial cultures: Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 51299, Escherichia coli ATCC 25922, and after that on clinical strains. For testing the antibacterial activity, agar diffusion and microdilution methods were used. The inhibition zones (IZ) for standard bacterial cultures were from 31.0 ± 0.57 mm to 35.0 ± 1.15 mm. The minimum inhibitory concentracion (MIC) for essential oil was tested using the broth dilution method. The values were in the range of 0.098 mg/ml-1.562 mg/ml. O. compactum essential oil provided strong antibacterial activity for all tested microorganisms. The antibacterial activity of essential oil depends largely on the main components: carvacrol and thymol. Clinical isolates, which are more resistant in comparison with laboratory strains, are almost equally sensible to O. compactum essential oil. This essential oil could be an ideal replacement for conventional antimicrobial products, especially if we consider the increasing resistance to implemented antibiotics. In the future, O. compactum essential oil could be an option in the treatment of gynecological infections.

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“…The best concentrations of EOs that are effective against different microorganisms depend on the type’s of EOs and biopolymers used as shown in Table 2 . According to the study conducted by Helal et al [ 59 ], the results showed that the EOs from Origanum vulgare showed the lowest minimum inhibitory concentration (MIC) of 0.025 mg/mL for Staphylococcus aureus and Streptococcus pyogenes if compared with Mentha cervina (0.05 mg/mL) and Ocimum basilicum (1.6 mg/mL). Besides that, the EOs from O. vulgare , Ocimum basilicum and Mentha cervina were the most active against all isolates, with the inhibitory zone ranges between 17 and 45 mm.…”

Section: Starch-based Polymer Film Incorporated With Antimicrobialmentioning

confidence: 99%

Antimicrobial Activities of Starch-Based Biopolymers and Biocomposites Incorporated with Plant Essential Oils: A Review

et al. 2020

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Recently, many scientists and polymer engineers have been working on eco-friendly materials for starch-based food packaging purposes, which are based on biopolymers, due to the health and environmental issues caused by the non-biodegradable food packaging. However, to maintain food freshness and quality, it is necessary to choose the correct materials and packaging technologies. On the other hand, the starch-based film’s biggest flaws are high permeability to water vapor transfer and the ease of spoilage by bacteria and fungi. One of the several possibilities that are being extensively studied is the incorporation of essential oils (EOs) into the packaging material. The EOs used in food packaging films actively prevent inhibition of bacteria and fungi and have a positive effect on food storage. This work intended to present their mechanical and barrier properties, as well as the antimicrobial activity of anti-microbacterial agent reinforced starch composites for extending product shelf life. A better inhibition of zone of antimicrobial activity was observed with higher content of essential oil. Besides that, the mechanical properties of starch-based polymer was slightly decreased for tensile strength as the increasing of essential oil while elongation at break was increased. The increasing of essential oil would cause the reduction of the cohesion forces of polymer chain, creating heterogeneous matrix and subsequently lowering the tensile strength and increasing the elongation (E%) of the films. The present review demonstrated that the use of essential oil represents an interesting alternative for the production of active packaging and for the development of eco-friendly technologies.

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Antimicrobial Efficiency of Essential Oils from Traditional Medicinal Plants of Asir Region, Saudi Arabia over Drug Resistant Isolates

Cited by 10 publications

References 13 publications

Antitumor, Antimicrobial activities and Phytochemicals Constituent of different Extracts of Pulicaria undulata (Forssk.) Oliver. Grown Naturally in Saudi Arabia

Antitumor, Antimicrobial activities and Phytochemicals Constituent of different Extracts of Pulicaria undulata (Forssk.) Oliver. Grown Naturally in Saudi Arabia

Antibacterial activity of Origanum compactum essential oil tested on vaginal and cervical clinical bacterial strains

Antimicrobial Activities of Starch-Based Biopolymers and Biocomposites Incorporated with Plant Essential Oils: A Review

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