Antimicrobial efficacy of zinc oxide nanoparticle-coated aligners on Streptococcus mutans and Candida albicans

Anita, Prathima; Sathyanarayana, Haritha Pottipalli; Kumar, Kennedy; Ramanathan, Krishnapriya; Kailasam, Vignesh

doi:10.1016/j.ajodo.2021.11.020

Cited by 11 publications

(9 citation statements)

References 39 publications

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“…coli bacteria increased, while ZnO NPs coatings show a minimal effect against C. albicans . Wang et al .…”

Section: Resultsmentioning

confidence: 99%

“…ZnO NPs produced by RF magnetron sputtering with a mean size of 20 nm improved the antibacterial effect of the hydroxyapatite substrate as the zone of inhibition growth of E. coli bacteria increased, 44 while ZnO NPs coatings show a minimal effect against C. albicans. 45 Wang et al 17 produced ZnO NPs to nano-ZnO films onto Ti substrates by RF magnetron sputtering, increasing the deposition time, which increased Zn elemental concentration and the Zn ions released from the surfaces after soaking for 14 days. These ZnOmodified surfaces exhibited an antibacterial effect that occurred in a concentration-dependent manner.…”

Section: Evaluation Of the Surfaces' Antimicrobial Activitymentioning

confidence: 99%

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Effects of Zn–ZnO Core–Shell Nanoparticles on Antimicrobial Mechanisms and Immune Cell Activation

Fialho,

Costa-Barbosa,

Sampaio

et al. 2023

ACS Appl. Nano Mater.

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The deposition of zinc−zinc oxide nanoparticles (Zn−ZnO NPs) onto porous Ta 2 O 5 surfaces enriched with calcium phosphate by DC magnetron sputtering was investigated to improve the surface antimicrobial activity without triggering an inflammatory response. Different sizes and amounts of Zn NPs obtained by two optimized different depositions and an additional thin carbon (C) layer deposited over the NPs were explored. The deposition of the Zn NPs and the C layer mitigates the surface porosity, increasing the surface hydrophobicity and decreasing the surface roughness. The possible antimicrobial effect and immune system activation of Zn−ZnO NPs were investigated in Candida albicans and macrophage cells, respectively. It was found that the developed surfaces displayed a fungistatic behavior, as they impair the growth of C. albicans between 5 and 24 h of culture. This behavior was more evident on the surfaces with bigger NPs and the highest amounts of Zn. The same trend was observed in both reactive oxygen species (ROS) generation and loss of C. albicans' membrane integrity. After 24 h of culture, cell toxicity was also dependent on the amount of the NPs. Cell toxicity was observed in surfaces with the highest amount of Zn NPs and with the C layer, while cells were able to grow without any signs of cytotoxicity in the porous surfaces with the lowest amount of NPs. The same Zn-dose-dependent behavior was noticed in the TNF-α production. The Zn-containing surfaces show a vastly inferior cytokine secretion than the lipopolysaccharide (LPS)-stimulated cells, indicating that the modified surfaces do not induce an inflammatory response from macrophage cells. This study provides insights for understanding the Zn amount threshold that allows a simultaneous inhibition of the fungi growth with no toxic effect and the main antimicrobial mechanisms of Zn−ZnO NPs, contributing to future clinical applications.

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“…coli bacteria increased, while ZnO NPs coatings show a minimal effect against C. albicans . Wang et al .…”

Section: Resultsmentioning

confidence: 99%

Section: Evaluation Of the Surfaces' Antimicrobial Activitymentioning

confidence: 99%

Effects of Zn–ZnO Core–Shell Nanoparticles on Antimicrobial Mechanisms and Immune Cell Activation

Fialho,

Costa-Barbosa,

Sampaio

et al. 2023

ACS Appl. Nano Mater.

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“…This distinctive characteristic assumes pivotal significance in combatting infections and restraining the proliferation of bacteria on medical devices and implants. [ 31–36 ]…”

Section: Introductionmentioning

confidence: 99%

“…This distinctive characteristic assumes pivotal significance in combatting infections and restraining the proliferation of bacteria on medical devices and implants. [31][32][33][34][35][36] Furthermore, ZnO NPs exhibit low physiological toxicity, establishing their secure utilization within the confines of the human body. This attribute takes on heightened importance within DDSs, where carriers must refrain from inflicting harm and steer clear of eliciting significant side effects.…”

Section: Introductionmentioning

confidence: 99%

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Valladão,

da Silva,

Souza

2024

Macromolecular Symposia

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The present investigation offers a thorough bibliometric exploration spotlighting the pivotal utilization of zinc oxide nanostructures, encompassing both zero‐dimensional (0D) nanoparticles and one‐dimensional (1D) nanostructures, within the realm of nanotechnology‐driven drug delivery systems. This analysis particularly illuminates the distinctive potential of these nanostructures in the cancer therapy context, not merely as carriers and deliverers of pharmaceutical agents, but as entities capable of selectively inducing apoptosis in cancer cells through the orchestrated generation of reactive oxygen species (ROS). Recent research endeavors notably underscore the application prospects of ZnO nanostructures in domains like DNA cleavage, bioimaging, and agricultural defense mechanisms. Moreover, the study elucidates the pronounced enhancement in solubility and biocompatibility that these nanostructures bring about when harmoniously integrated into polymeric nanocomposites. Concomitantly, the involvement of polymers in this symbiotic system is unveiled, wherein they play a multifaceted role in dictating release selectivity, thereby facilitating targeted and efficacious interactions with tissues. Functionally engineered polymeric nanocomposites emerge as promising candidates for targeted delivery modalities in cancer treatment, demonstrating an affinity for specific cell receptors and exhibiting enhanced cellular uptake within the size range of 100–200 nm. The study unearths robust associations among pivotal research terminologies through an exhaustive analysis of Link Strength Between Items (LSBI), culminating in the presentation of a cogent map delineating the evolving trends and forthcoming trajectories in this dynamic domain. In summation, this all‐encompassing bibliometric inquiry serves as a poignant testament to the prodigious potential of zinc oxide nanostructures in the realm of forthcoming nanotechnology‐driven drug delivery paradigms.

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“…The effectiveness of zinc-oxide-nanoparticle-coated aligners as an antimicrobial agent against Streptococcus mutans and Candida albicans has recently been studied [ 14 , 15 ]. In that study, it was reported that the maximal antibacterial impact was not seen until 2 days after the application of the ZnO-nanocoated aligners, and that it lasted for 7 days after that.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of the Bioactive Compound Content and Antibacterial Activities in Curcuma Longa Using Zinc Oxide Nanoparticles

Aldayel

2023

Molecules

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Incorporating nanoparticles into plant cultivation has been shown to improve growth parameters and alter the bioactive component compositions of many plant species, including Curcumin longa. The aim of the current study was to investigate the effects of foliar application of zinc oxide nanoparticles on the content of bioactive compounds and their antibacterial activities against potential bacterial pathogens. To this end, C. longa leaves were treated with different doses of ZnO NPs to see how this affected their bioactive component composition. The effect of different doses of ZnO NPs on the accumulation of bisdemethoxycurcumin, demethoxycurcumin, and curcumin in ethanolic extracts of C. longa rhizomes was evaluated using high-performance liquid chromatography (HPLC). When compared to the control treatment, foliar spraying with (5 and 40 mgL−1) of ZnO NPs increased bisdemethoxycurcumin, demethoxycurcumin, and curcumin levels approximately (2.69 and 2.84)-, (2.61 and 3.22)-, and (2.90 and 3.45)-fold, respectively. We then checked whether the ethanolic extracts produced from the plantlets changed in terms of their phytochemical makeup and antibacterial properties. Furthermore, the results revealed that C. long-ZnO NPs displayed antibacterial activity against the tested S. aureus and P. aeruginosa bacterium strains, but had a few effect against E. coli. The MIC for P. aeruginosa was 100 g/mL. The time–kill studies also revealed that ZnO NPs at 4 MIC killed P. aeruginosa, Actinobacteria baumannii, and Bacillus sp. after 2 h, while S. aureus did not grow when treated with 4 × MIC of the extract for 6 h. The strongest antibacterial activity was seen in the extract from plantlets grown without nanoparticles for P. aeruginosa, whereas it was seen in the extract from plantlets grown in the presence of 5 mg/L ZnO NPs for E. coli, S. aureus, and P. aeruginosa. These findings show that ZnO NPs are powerful enhancers of bioactive compound production in C. longa, a trait that can be used to combat antibiotic resistance in pathogenic bacterial species.

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Antimicrobial efficacy of zinc oxide nanoparticle-coated aligners on Streptococcus mutans and Candida albicans

Cited by 11 publications

References 39 publications

Effects of Zn–ZnO Core–Shell Nanoparticles on Antimicrobial Mechanisms and Immune Cell Activation

Effects of Zn–ZnO Core–Shell Nanoparticles on Antimicrobial Mechanisms and Immune Cell Activation

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Enhancement of the Bioactive Compound Content and Antibacterial Activities in Curcuma Longa Using Zinc Oxide Nanoparticles

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