Antimicrobial efficacy of a novel povidone iodine contact lens disinfection system

Yamasaki, Katsuhide; Saito, Fumio; Ota, Ritsue; Kilvington, Simon

doi:10.1016/j.clae.2017.12.001

Cited by 21 publications

(21 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 13 Furthermore, a study comparing a P-I MPS to a PQ-1 plus PHMB MPS found they were both effective against in vitro planktonic bacteria (standard strain S. marcescens ; and clinically isolated P. aeruginosa, Delftia acidovorans, Stenotrophomonas maltophilia, S. aureus , and S. epidermidis ), but only P-I was effective against biofilms isolated from CL cases. 85 Studies have also proven P-I is effective against in vitro clinically isolated 86 and known pathogenic 87 , 88 strains of Acanthamoeba cysts and trophozoites. From these studies, P-I can achieve and even greatly exceed safety standards for CL MPS and is safe for ocular use in CL disinfection.…”

Section: Resultsmentioning

confidence: 99%

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Bradley¹,

Sicks²,

Pucker³

2021

OPTO

View full text Add to dashboard Cite

Purpose: Preservatives are essential for preventing contact lens (CL)-related microbial keratitis (MK). The purpose of this review is to summarize the current knowledge related to the use of common ophthalmic preservatives in CL care products with respect to both safety and efficacy. Methods: Manuscripts written in English were obtained by searching PubMed.gov with the term contact lens plus antimicrobial, benzalkonium chloride, biguanide, Aldox, polyquaternium, preservative, thimerosal, EDTA (ethylenediaminetetraacetic acid), chlorhexidine, or blister pack. Results: This review found that first-generation preservatives are no longer used in CL multipurpose solutions (MPS) due to their high levels of ocular toxicity. Modern, highmolecular-weight preservatives, including polyquaternium-1 (PQ-1) and biguanides (PHMB), are generally effective against bacteria, minimally effective against fungi, and not effective against Acanthamoeba. PQ-1 and PHMB are likely safe when used with CLs, but they may cause ocular adverse events, with roughly equal risk between the two preservatives. Some CL MPS contain both PQ-1 and PHMB, but no increased risk of adverse events has been reported when combining the two. Hydrogen-peroxide (H 2 O 2 ) solutions are effective against all common ocular microbes, including Acanthamoeba, and they have been proven safe with proper compliance. Povidone-iodine (P-I) solutions are not currently commercially available in North America, but they have been shown in other countries to be safe and effective. Conclusion:Patients should be monitored when using PQ-1 or PHMB-containing solutions since they have been associated with ocular adverse events. If events are detected, patients should be switched to an alternative solution. H 2 O 2 or P-I solutions are preferred for any patient who may expose their CLs to water because they are the only solution categories effective against Acanthamoeba.

show abstract

Section: Resultsmentioning

confidence: 99%

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Bradley¹,

Sicks²,

Pucker³

2021

OPTO

View full text Add to dashboard Cite

show abstract

“…Also, as Acanthamoeba are eukaryotic organisms, as are humans, there is the probability that killing these would have toxic effects on human cells, so getting the right balance between killing the amoebae and toxicity to human cells may be difficult. The five most commonly used disinfectants in contact lens care solutions are hydrogen peroxide, PHMB (polyhexanide; polyaminopropyl biguanide; also known as Dymed®), polyquaternium-1 (PQ1, also known as POLYQUAD®), myristamidopropyl dimethylamine (MAPD, also known as ALDOX®) and alexidine, although another MPDS uses polylysine as the main disinfectant [260,[292][293][294][295][296][297] (Table 4). Some care solutions combine some of the above agents or incorporate additional agents (i.e., amidoamine and chlorite) to boost antimicrobial efficacy.…”

Section: Disinfectantsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

show abstract

“…Despite the advantages of using CL [ 8 – 11 ], adverse reactions with different severities may occur from clinically inconsequential to potentially vision-threatening. Discomfort, corneal staining, dryness, microbial keratitis, corneal neovascularization, allergic conjunctivitis, and corneal infection are the main complications limiting the success of the CL and eventually may lead to the discontinuation of CL [ 5 , 7 , 10 , 12 – 18 ]. One study showed that 6% of Contact Lens Wearers (CLWs) have experienced a complication each year [ 18 ] and another study in the U.…”

Section: Introductionmentioning

confidence: 99%

Determining the information needs of contact lens wearers for better education and more support: a qualitative study

et al. 2021

View full text Add to dashboard Cite

Background Designing educational interventions tailored to the needs of Contact Lens Wearers (CLWs) are important and necessary. The present study aimed to determine the information needs of CLWs to educate and provide information to them to increase their knowledge and reduce complications and non-compliance behaviors. Methods A qualitative approach was applied and semi-structured interviews were conducted in three contact lenses (CL) clinics in Iran among all their practitioners and 24 purposively selected patients. Data were analyzed using the Lundman and Graneheim conventional content analysis. Results The qualitative analysis revealed knowledge and skill themes as two main categories. The knowledge category includes five subcategories of basic information for the CLWs, acquaintance with the CL, caring for CL, hygiene and vigilance of CL, and challenges of using CL. The skill category consists of two subcategories, including handling/insertion and removal of the CL, and stabilization of learned information. Moreover, 36 sub-subcategories emerged from these seven subcategories that reflected the information needs of CLWs. Conclusions A clear understanding of CLWs’ information needs can help to design and develop appropriate educational approaches to overcome training barriers such as physicians’ time constraints and high workload. Moreover, it can help deal with CLWs’ insufficient knowledge and provide the required information simply and practically with the possibility of enough repetition.

show abstract

Antimicrobial efficacy of a novel povidone iodine contact lens disinfection system

Cited by 21 publications

References 27 publications

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Determining the information needs of contact lens wearers for better education and more support: a qualitative study

Contact Info

Product

Resources

About