Antimicrobial efficacy and optimized cell adhesion from defined plasma polymerised multilayer structures involving zinc acetylacetonate and allylamine

Lotz, Alexander; Heller, Martin; Dohm, Nina; Cierniak, Peter; Bender, Katja; Jansen, B.; Förch, Renate

doi:10.1039/c2jm30344b

Cited by 9 publications

(9 citation statements)

References 40 publications

(52 reference statements)

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“…Related work by Lischer et al on Ag‐burst release systems suggests that at very low concentrations of potentially both metals within the same polymer there is a potential for reducing both gram negative and gram positive bacterial colonisation without compromising cytocompatibility. In order to extend the antimicrobial effect of the described zinc containing films to several days and weeks an accompanying paper describes the addition of cytocompatible top‐layers that act as a barrier allowing for control over the release rate of zinc from a multilayer structure 21…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity and Cyto‐Compatibility of Plasma Polymerized Zinc Acetylacetonate Thin Films

Malzahn

Duque

Ciernak

et al. 2012

Plasma Processes & Polymers

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Plasma polymerized thin films deposited from zinc acetylacetonate in a low pressure RF capacitively coupled plasma reactor have been studied to correlate the zinc content to the metal ion release properties, antimicrobial activity and cytocompatibility. Zinc content and zinc release properties were studied using inductively coupled plasma optical emission spectroscopy (ICP‐OES) and results were correlated to those from different standard methods of surface analysis. The coatings were shown to act as a zinc reservoir, allowing for a fast release of zinc within a few hours of being in contact with aqueous solution. For all films studied a log 106 reduction in the growth of Staphylococcus aureus was observed. The results show the films to be cyto‐compatible towards NIH 3T3 mammalian cells up to a zinc content of about 5 µg/cm2. magnified image

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity and Cyto‐Compatibility of Plasma Polymerized Zinc Acetylacetonate Thin Films

Malzahn

Duque

Ciernak

et al. 2012

Plasma Processes & Polymers

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“…The thermal decomposition of zinc acetylacetonate hydrate [Zn(C 5 H 7 O 2 ) 2 .xH 2 O] has been found to yield metallic zinc and zinc oxide [30,58,59]. The ZnO can get incorporated into polymer surface as metallic zinc or zinc oxide.…”

Section: Film Compositionmentioning

confidence: 99%

“…Surface modification techniques such as block co-polymerization [26,27], covalent grafting of hydrophilic groups to surfaces [28], nanoparticle functionalization [29,30], atom transfer radical polymerization [31], Radio Frequency plasma deposition and modifications of surfaces have been used to fabricate surfaces showing antifouling properties. Kim et al modified nanofiltration thin film composite membranes to be more hydrophilic by a treatment with NH 3 plasma.…”

Section: Introductionmentioning

confidence: 99%

In-Situ Surface Modification of Terpinen-4-ol Plasma Polymers for Increased Antibacterial Activity

et al. 2020

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Surface modification of thin films is often performed to enhance their properties. In this work, in situ modification of Terpinen-4-ol (T4) plasma polymer is carried out via simultaneous surface functionalization and nanoparticle immobilization. Terpinen-4-ol plasma polymers surface were decorated with a layer of ZnO nanoparticles in an oxygen plasma environment immediately after polymer deposition. A combination of hydrophilic modification and ZnO nanoparticle functionalization of the T4 polymer surface led to an enhancement in antibacterial properties by factor of 3 (from 0.75 to 0.25 CFU.mm−2). In addition, ZnO nanoparticle-modified coatings demonstrated improved UV absorbing characteristics in the region of 300–400 nm by 60% relative to unmodified coatings. The ZnO modified coatings were transparent in the visible region of 400–700 nm. The finding points towards the potential use of ZnO nanoparticle-modified T4 plasma polymers as optically transparent UV absorbing coatings.

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“…OWS has been described previously and allows for the determination of both refractive index and thickness changes occurring as the metal ions leach from the nanocomposite (48,77). The change in optical parameters of the films can be correlated to a measured decrease in zinc within the film by inductively coupled plasma optical emission spectroscopy (ICP-OES) data (48,78). The change in optical parameters of the films can be correlated to a measured decrease in zinc within the film by inductively coupled plasma optical emission spectroscopy (ICP-OES) data (48,78).…”

mentioning

confidence: 99%

“…To tailor the release rate of the metal from the polymer matrix, a secondary top layer that acts to reduce the diffusion rate of the metal out of the polymer has been suggested (78). After that time, no further metal release is observed, even though in both cases it was shown that the metal has not fully leached from the film.…”

mentioning

confidence: 99%

Antimicrobial Bioactive Polymer Coatings

Förch

Duque²,

Lotz³

2014

Comprehensive Materials Processing

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Antimicrobial efficacy and optimized cell adhesion from defined plasma polymerised multilayer structures involving zinc acetylacetonate and allylamine

Cited by 9 publications

References 40 publications

Antimicrobial Activity and Cyto‐Compatibility of Plasma Polymerized Zinc Acetylacetonate Thin Films

Antimicrobial Activity and Cyto‐Compatibility of Plasma Polymerized Zinc Acetylacetonate Thin Films

In-Situ Surface Modification of Terpinen-4-ol Plasma Polymers for Increased Antibacterial Activity

Antimicrobial Bioactive Polymer Coatings

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