Antimicrobial Effects of Varied Combinations of Meropenem, Sulbactam, and Colistin on a Multidrug-Resistant Acinetobacter baumannii Isolate That Caused Meningitis and Bacteremia

Lee, Chen‐Hsiang; Tang, Ya-Fen; Su, Lin‐Hui; Chien, Chun-Chih; Liu, Jien-Wei

doi:10.1089/mdr.2008.0840

Cited by 48 publications

(25 citation statements)

References 7 publications

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“…22,24,25 Colistin activity can be enhanced when combined with antibiotics with different action as carbapenems, rifampicin, ceftazidime. 26,27,28 Present study observd 50% synergism, 30% additive effect, 20% indifference while combining colistin with imipenem. In accordance with the present study Souli et al 29 reported 56.3% synergism and 43.7% indifference.…”

Section: Discussionmentioning

confidence: 54%

In vitro efficacy of synergistic antibiotic combinations in imipenem resistant Pseudomonas aeruginosa strains

Farzana

Shamsuzzaman

2017

Bangladesh J Med Microbiol

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imipenem resistant isolates ranged from > _ 256 mg/L to < _ 8 mg/L for imipenem, > _ 1024 mg/L to < _ 64 mg/L for ceftriaxone, > _ 256 mg/L to < _ 8 mg/L for amikacin, > _ 16 mg/L to < _ 2 mg/L for colistin, > _ 512 mg/L to < _ 16 mg/L for piperacillin/tazobactam. Among antibiotic combinations, piperacillin/tazobactam-amikacin was most effective with 80% synergism next to which was imipenem-amikacin with 60% synergism, then imipenem-colistin with 50% synergism, imipenem-ceftriaxone with 30% synergism. Only one combination (piperacillin/tazobactum -imipenem showed 20% antagonism. All these combinations had considerable proportion of additive effect which is also desirable for these multi drug resistant isolates

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Section: Discussionmentioning

confidence: 54%

In vitro efficacy of synergistic antibiotic combinations in imipenem resistant Pseudomonas aeruginosa strains

Farzana

Shamsuzzaman

2017

Bangladesh J Med Microbiol

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“…Resistance to colistin is the potential problem with colistin monotherapy. In recent years, many studies have investigated other antibiotics either as a monotherapy or in combination with other antibiotics to increase the clinical success and to prevent resistance to colistin [1,2,19,25,26,27,28,29,30]. Tigecycline and sulbactam have in vitro activity against carbapenem-resistant A. baumannii, and in some clinical studies the results were encouraging [8,13,30,31,32].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Sulbactam and Its Combination with Imipenem, Colistin and Tigecycline in an Experimental Model of Carbapenem-Resistant Acinetobacter baumannii Sepsis

Dinç

Demiraslan²,

Elmalı³

et al. 2013

Chemotherapy

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Background: In recent years, multidrug-resistant Acinetobacter baumannii has been reported as an important nosocomial pathogen, and treatment options are limited. The aim of this study was to investigate the additional effect of sulbactam on monotherapy with colistin, tigecycline and imipenem in experimental sepsis with carbapenem-resistant A. baumannii in mice. Methods: Sepsis was developed in 8- to 10-week-old BALB/c mice by an intraperitoneal injection of A. baumannii. Antibiotic was given intraperitoneally 2 h after bacterial inoculation. Each experimental group had 15 mice and was divided into 3 subgroups. Mice were sacrificed at 24, 48 or 72 h. Lung, liver, heart and spleen samples were cultured, and homogenates of lung and liver were used to detect the number of colony-forming units per gram. Bacterial clearance was compared in lung and liver at different time points. Results: Imipenem did not decrease the bacterial load, but the other antibiotics showed significant bactericidal activity compared with the control group, and the combination of imipenem with sulbactam decreased the bacterial load in lung and liver. However, the addition of sulbactam to colistin and tigecycline had no significant effect on bacterial counts. Only the addition of sulbactam to imipenem showed better bactericidal activity compared to imipenem alone. Conclusions: These results suggested that combining sulbactam with tigeycline or colistin does not increase the efficiency of these antibiotics.

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“…12 Association of antibiotics have been suggested to improve patient outcome, but the literature regarding this issue is scarce. 7,[13][14][15] Rifampicin and aminoglycosides are drugs that can be used in association with polymyxins or carbapenems.…”

Section: Discussionmentioning

confidence: 99%

Mortality rate in patients with nosocomial Acinetobacter meningitis from a Brazilian hospital

Tuon¹,

Penteado-Filho²,

Amarante³

et al. 2010

Braz J Infect Dis

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Background:The mortality rate due to Acinetobacter baumannii nosocomial meningitis (ANM) is high. Objective: The aim of this study was to evaluate the factors that have infl uence over the outcomes in ANM patients. Methods: A retrospective analysis of 22 cases of ANM was conducted in a hospital with high incidence of multidrug resistance. Results: The mean age of patients was 43 years (21 to 91) and 54.5% were male. All ANM cases occurred within 60 days of admission and the mean duration of illness was of 18.2 days. All cases were associated with previous neurosurgical procedures: elective surgery (27.2%), external shunt (54.4%) and emergency surgery due to trauma (18.1%). Imipenem resistance was observed in 40.9% of cases, but ampicillin/sulbactam resistance was lower (27.2%). The mortality rate of ANM patients was of 72.7%. The only risk factor associated with mortality was inappropriate therapy within fi ve days after CSF collection. All patients who survived the meningitis episode had received appropriate therapy, in contrast to only 69.2% of those who did not survive (OR = 5.15; IC = 0.45-54.01). Conclusions: The high mortality rate observed in our study suggests the need for aggressive empirical treatment with addition of drugs, including intrathecal therapy, where multi-resistant A. baumannii is endemic.

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Antimicrobial Effects of Varied Combinations of Meropenem, Sulbactam, and Colistin on a Multidrug-Resistant Acinetobacter baumannii Isolate That Caused Meningitis and Bacteremia

Cited by 48 publications

References 7 publications

In vitro efficacy of synergistic antibiotic combinations in imipenem resistant Pseudomonas aeruginosa strains

In vitro efficacy of synergistic antibiotic combinations in imipenem resistant Pseudomonas aeruginosa strains

Efficacy of Sulbactam and Its Combination with Imipenem, Colistin and Tigecycline in an Experimental Model of Carbapenem-Resistant <b><i>Acinetobacter baumannii</i></b> Sepsis

Mortality rate in patients with nosocomial Acinetobacter meningitis from a Brazilian hospital

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