Antimicrobial effects of Indian medicinal plants against acne-inducing bacteria

Abstract

Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. The present study was conducted to evaluate antimicrobial activities of Indian medicinal plants against these etiologic agents of acne vulgaris. Ethanolic extracts of Hemidesmus indicus (roots), Eclipta alba (fruits), Coscinium fenestratum (stems), Curcubito pepo (seeds), Tephrosia purpurea (roots), Mentha piperita (leaves), Pongamia pinnata (seeds), Symplocos racemosa (barks), Euphorbia hirta (roots), Tinospora cordyfolia (roots), Thespesia populnea (roots), and Jasminum officinale (flowers) were tested for antimicrobial activities by disc diffusion and broth dilution methods. The results from the disc diffusion method showed that 07 medicinal plants could inhibit the growth of Propionibacterium acnes. Among those Hemidesmus indicus, Coscinium fenestratum, Tephrosia purpurea, Euphorbia hirta, Symplocos racemosa, Curcubito pepo and Eclipta alba had strong inhibitory effects. Based on a broth dilution method, the Coscinium fenestratum extract had the greatest antimicrobial effect. The MIC values were the same (0.049 mg/ml) for both bacterial species and the MBC values were 0.049 and 0.165 mg/ml against Propionibacterium acnes and Staphylococcus epidermidis, respectively. In bioautography assay, the Coscinium fenestratum extract produced strong inhibition zones against Propionibacterium acnes. Phytochemical screening of Coscinium fenestratum revealed the presence of alkaloid which could be responsible for activity. Taken together, our data indicated that Coscinium fenestratum had a strong inhibitory effect on Propionibacterium acnes and Staphylococcus epidermidis.

Evaluation of Phytochemicals and Synergistic Interaction Between Plant Extracts and Antibiotics for Efflux Pump Inhibitory Activity Against Salmonella Enterica Serovar Typhimurium Strains

“…Screening of the extracts of above five selected synergistic medicinal plants for various phytochemical constituents carried out using standard methods [24][25][26][27][28][29] …”

Isolation, Purification and Application of Secondary Metabolites From Seaweed Hypnea Cervicornis.

“…The plates are dried and spots can be visualized by using a suitable spraying reagent. For glycosides Iodine chamber is used while for alkaloids Dragendroff's reagent is used for identification (Kumar et al, 2007) It is an analytical method used for identifying different substances within a test sample. It also helps in identifying trace elements in a sample.…”

Ethnobotanical Identification and Anti-microbial Evaluation of Some Anti-Diarrhoeal Plants Used by the Samburu Community, Kenya

“…For instance in one study the ethanolic extracts of Hemidesmus indicus, Coscinium fenestratum, Tephrosia purpurea, Euphorbia hirta, Symplocos racemosa, Curcubito pepo and Eclipta alba were screened against Propionibacterium acnes and Staphylococcus epidermidis. These extracts showed significant activity against the test organisms with C. fenestratum showing the strongest inhibitory activity (Kumar et al, 2007). Therefore, medicinal plants are increasingly being projected as a suitable alternative source because of their often multiple targets, minor side effects, low potentials to cause resistance and low costs (Jassim and Naji, 2003).…”