Antimicrobial effects of craniopharyngioma cystic fluid

Jokonya, Luxwell; Reid, Tsungai; Kasambala, Maritha; Mduluza-Jokonya, Tariro Lavender; Fieggen, Graham; Mduluza, Takafira; Kalangu, K; Naicker, Thajasvarie

doi:10.1007/s00381-020-04825-x

Cited by 3 publications

(2 citation statements)

References 16 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the best of our knowledge, amylase is being reported for the first time in craniopharyngioma cystic fluid in this study. Studies on the biochemical composition of the cystic fluid are scanty, and there have been reports of lipids, proteins, glucose, urea, creatinine, sodium, calcium, magnesium, phosphorous, chlorine, ALT, AST, and GGT, but none on amylase ( 7 , 8 , 14 , 34 , 35 ). The significance of this important finding remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Raised awareness of the cystic component for Ommaya reservoirs and intra-cystic drug therapies has resulted in several studies that explore the nature and contents of this cyst. We recently reported on the possible antimicrobial properties of the cystic craniopharyngioma fluid ( 14 , 15 ). This study aimed to assess the biochemical components of the CP fluid to elucidate any antimicrobial properties.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study

Jokonya

Mduluza-Jokonya²,

Mwale³

et al. 2022

Front. Surg.

Self Cite

View full text Add to dashboard Cite

IntroductionCraniopharyngioma is a rare brain tumour. Despite being histologically benign, it behaves aggressively and is often difficult to manage. Descriptive epidemiological data on the tumour is lacking in sub-Saharan Africa, and there is none for Zimbabwe. The tumour usually has a cystic component that has been raising interest in the past decade. Few studies have looked at the biochemical composition thereof. This study aims to give a landscape view of craniopharyngiomas (CPs) in Zimbabwe and then profile the biochemical properties of the cystic component of paediatric adamantinomatous craniopharyngioma.MethodologyA prospective cohort study was done in Zimbabwe over a 2-year period to study the epidemiological distribution of craniopharyngioma and examine the biochemical composition of adamantinomatous craniopharyngioma cystic fluid in the paediatric population. Fifteen patients were recruited who had craniopharyngiomas, and of those, nine paediatric adamantinomatous craniopharyngiomas had fluid analysed for biochemical components. SPSS statistical package was used to analyse the data. Descriptive statistics were used for epidemiological data.ResultsThe incidence of CP was calculated to be 0.53 per million person-years. Incidence among the paediatric population 0–14 years was 1.2 per 100,000 person-years. Several biological components were found to be elevated significantly compared to serum and cerebral spinal fluid (CSF). These are sodium, potassium, urea, alkaline phosphatase, phosphate, magnesium, albumin, gamma-glutamyl transferase, calcium, low-density lipids, and glucose.ConclusionThe incidence of CP in Zimbabwe is similar to the rest of the world. Some biochemical components have been noted to be markedly elevated in the cystic fluid and were mirroring serum rather than CSF in concentration.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study

Jokonya

Mduluza-Jokonya²,

Mwale³

et al. 2022

Front. Surg.

Self Cite

View full text Add to dashboard Cite

show abstract

Treatment of Cystic Craniopharyngiomas: An Update

Bianchi

Benato

Massimi

2022

Advances and Technical Standards in Neurosurgery

View full text Add to dashboard Cite

Adamantinomatous craniopharyngioma: evolution in the management

Massimi,

Palombi,

Musarra

et al. 2023

Childs Nerv Syst

View full text Add to dashboard Cite

Background In spite of the continuous progresses in pediatric neurosurgery, adamantinomatous craniopharyngioma (AC) remains a challenging tumor due to its proximity to optic pathways, pituitary gland, hypothalamus, and Willis’ circle, which can result in significant endocrine, cognitive, and neurological morbidity after treatment with subsequent impact on the patient’s quality of life (QoL). The relevance that QoL has today explains the changes in the management of AC observed over the time. The goal of the present article is to provide a historical background, to show the milestones in the changes of the AC treatment, and to analyze the current main options to manage such a challenging tumor. Material and methods The pertinent literature has been reviewed. Moreover, a comparison between the past and recent personal series is reported. Results Three main eras have been identified. The first (named Cushing era) was characterized by the need to realize a harmless surgery and to define the best way to approach AC; the second (microscope era) was characterized by a tremendous technical and technological development, with remarkable results in term of safe tumor resection and control but relatively poor QoL outcomes; and the third one (current period) is characterized by an increasing integration between surgery and adjuvant treatments, with relatively minor tumor control but significant improvement of QoL (comparable overall survival). The authors’ experience reflects these changes. Two groups of children were compared: 52 cases (mean follow-up: 17.5 years) belong to the historical series (group 1, 1985–2003, aggressive surgical management) and 41 (mean follow-up: 8.5 years) to the current one (Group 2, 2004–2021, integrated management). No significant differences between the two groups were detected about recurrence rate, surgical mortality, and overall survival. However, Group 2 showed significant lower rates of postoperative panhypopituitarism, obesity, and visual deterioration. Conclusions Radical surgery allows for a good AC control with a low rate of recurrence but high risk of permanent morbidity. Despite the greater number of recurrences and surgeries, the more conservative policy, based on a combination of treatments, seems to provide the same tumor control with a better QoL. The advances in trans-nasal and trans-ventricular endoscopy, in proton therapy and in the management of the AC cyst are the main factors that allowed such an improvement.

show abstract

Antimicrobial effects of craniopharyngioma cystic fluid

Cited by 3 publications

References 16 publications

Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study

Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study

Treatment of Cystic Craniopharyngiomas: An Update

Adamantinomatous craniopharyngioma: evolution in the management

Contact Info

Product

Resources

About