Antimicrobial effect of oxidized cellulose salts

Vytřasová, Jarmila; Tylsova, Andrea; Brožková, Iveta; Červenka, Libor; Pejchalová, Marcela; Havelka, Pavel

doi:10.1007/s10295-008-0421-y

Cited by 17 publications

(9 citation statements)

References 11 publications

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“…The low pH of oxidized cellulose is necessary for its hemostyptic and bactericidal properties. Unlike the hemostatic properties, the bactericidal properties of oxidized cellulose can be enhanced by modification with silver and zinc ions [15]. …”

Section: Discussionmentioning

confidence: 99%

Comparison of regenerated and non-regenerated oxidized cellulose hemostatic agents

et al. 2013

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SummaryBackgroundOxidized cellulose is a well known and widely used surgical hemostat. It is available in many forms, but manufactured using either a nonregenerated or regenerated process.ObjectiveThis study compares the fiber structure, pH in solution, bactericidal effectiveness, and hemostatic effectiveness of an oxidized nonregenerated cellulose (ONRC; Traumastem®) and an oxidized regenerated cellulose (ORC; Surgicel® Original).MethodsIn vitro, fiber structures were compared using scanning electron microscopy, pH of phosphate buffer solution (PBS) and human plasma were measured after each cellulose was submerged, and bactericidal effect was measured by plating each cellulose with four bacteria. In vivo, time to hemostasis and hemostatic success were compared using a general surgery nonheparinized porcine liver abrasion model and a peripheral vascular surgery heparinized leporine femoral vessel bleeding model.ResultsUltrastructure of ONRC fiber is frayed, while ORC is smooth. ORC pH is statistically more acidic than ONRC in PBS, but equal in plasma. No difference in bactericidal effectiveness was observed. In vivo, ONRC provided superior time to hemostasis relative to ORC (211.2 vs 384.6 s, N = 60/group) in the general surgery model; and superior hemostatic success relative to ORC at 30 (60 vs. 15 %; OR: 13.5; 95 % CI: 3.72–49.1, N = 40/group), 60 (85 vs. 37.5 %; OR: 12.3; 95 % CI: 3.66–41.6), and 90 s (97.5 vs 70.0 %; OR: 21.1, 95 % CI: 2.28–195.9) in the peripheral vascular model.ConclusionONRC provides superior hemostasis and equivalent bactericidal effectiveness relative to ORC, which is likely due to its fiber structure than acidity.

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Section: Discussionmentioning

confidence: 99%

Comparison of regenerated and non-regenerated oxidized cellulose hemostatic agents

et al. 2013

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“…20 Furthermore, the antimicrobial properties of oxidized cellulose may provide an additional clinical benefit. [21][22][23] These properties, coupled with its ability to bind to other chemicals, have resulted in the use of oxidized cellulose in a number of haemostatic products. Polyethylene glycol provides the ability to absorb fluids quickly.…”

Section: Discussionmentioning

confidence: 99%

A multicentre, randomized clinical trial comparing the Veriset™ haemostatic patch with fibrin sealant for the management of bleeding during hepatic surgery

Öllinger

Mihaljevic

Schuhmacher

et al. 2013

HPB

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“…Oxidized cellulose has been widely used for many years as a wound healing material with excellent properties, such as high absorbability, antibacterial and antiviral properties, and non-toxic and antiadhesive effects (Mueller et al 2000;Jeschke et al 2005;Bassetto et al 2008;Vytrasova et al 2008). Due to its ability to initiate or accelerate blood coagulation at the site where it is applied, oxidized cellulose has been used as a hemostatic material (Masova et al 2003;Schonauer et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Cellulose-based materials as scaffolds for tissue engineering

et al. 2013

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Two types of cellulose-based materials, 6-carboxycellulose with 2.1 or 6.6 wt% of -COOH groups, were prepared and tested for potential use in tissue engineering. The materials were functionalized with arginine, i.e. an amino acid with a basic side chain, or with chitosan, in order to balance the relatively acid character of oxidized cellulose molecules, and were seeded with vascular smooth muscle cells (VSMC). The cell adhesion and growth were then evaluated directly on the materials, and also on the underlying polystyrene culture dishes. Of these two types of studied materials, 6-carboxycellulose with 2.1 wt% of -COOH groups was more appropriate for cell colonization. The cells on this material achieved an elongated shape, while they were spherical in shape on the other materials. The number of cells and the concentration (per mg of protein) of contractile proteins alpha-actin and SM1 and SM2 myosins, i.e. markers of the phenotypic maturation of VSMC, were also significantly higher on this material. Functionalization of the material with arginine and chitosan further improved the phenotypic maturation of VSMC. Chitosan also improved the adhesion and growth of these cells. In comparison with the control polystyrene dishes, the proliferation of cells on our cellulose-based materials was relatively low. This suggests that these materials can be used in applications where high proliferation activity of cells is not desirable, e.g. proliferation of VSMC on vascular prostheses. Alternatively, the cell proliferation might be enhanced by another more efficient modification, which would require further research.

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Antimicrobial effect of oxidized cellulose salts

Cited by 17 publications

References 11 publications

Comparison of regenerated and non-regenerated oxidized cellulose hemostatic agents

Comparison of regenerated and non-regenerated oxidized cellulose hemostatic agents

A multicentre, randomized clinical trial comparing the Veriset™ haemostatic patch with fibrin sealant for the management of bleeding during hepatic surgery

Cellulose-based materials as scaffolds for tissue engineering

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