Antimicrobial effect of gold nanoparticles in the formation of the Staphylococcus aureus biofilm on a polyethylene surface

Villa-Garcia, L.; Márquez-Preciado, Raúl; Magdaleno, Mariné Ortiz; Patrón-Soberano, Olga Araceli; Álvarez-Pérez, Marco Antonio; Pozos‐Guillén, Amaury; Sánchez-Vargas, Luis Octavio

doi:10.1007/s42770-021-00455-w

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…Gold is another noble metal used to prepare bactericidal thin film on the surface of different materials including medical devices due to its low toxicity and a great bio-affinity. Villa Garcia L. et al 51 reported coating ( via magnetron sputtering) of gold nanoparticles on polyethylene, a versatile polymeric material used in surgical instruments to temporary and permanent biomedical devices. The gold coated polyethylene demonstrated strong biofilm inhibition activity.…”

Section: Nano-enabled Antimicrobial Thin Films: Classes Design Approa...mentioning

confidence: 99%

Nano-enabled antimicrobial thin films: design and mechanism of action

Finina,

Mersha

2024

RSC Adv.

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Section: Nano-enabled Antimicrobial Thin Films: Classes Design Approa...mentioning

confidence: 99%

Nano-enabled antimicrobial thin films: design and mechanism of action

Finina,

Mersha

2024

RSC Adv.

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“…cholerae biotypes. The gold NPs have shown significantly higher efficacy in removing the biofilm and reducing the viability of the Staphylococcus aureus biofilm . Furthermore, studies have demonstrated the effectiveness of NPs against human fungal pathogens.…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

“…The gold NPs have shown significantly higher efficacy in removing the biofilm and reducing the viability of the Staphylococcus aureus biofilm. 105 Furthermore, studies have demonstrated the effectiveness of NPs against human fungal pathogens. The oxidation of AgNPs may occur upon exposure to oxygen in environmental and biological systems, which lead to the slow dissolution of metal ions.…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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“…Moreover, their antimicrobial activities against S. aureus and C. albicans were investigated. Since the majority of previously developed nanoparticles have been evaluated against single-species biofilms [ 39 , 40 , 41 ], the inhibitory activity of β-c-AuNPs on polymicrobial biofilms is a novel contribution to efforts in combatting the emergence of antimicrobial resistance.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Mixed Biofilms of Candida albicans and Staphylococcus aureus by β-Caryophyllene-Gold Nanoparticles

et al. 2023

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Polymicrobial biofilms, consisting of fungal and bacterial pathogens, often contribute to the failure of antimicrobial treatment. The growing resistance of pathogenic polymicrobial biofilms to antibiotics has led to the development of alternative strategies to combat polymicrobial diseases. To this end, nanoparticles synthesized using natural molecules have received significant attention for disease treatment. Here, gold nanoparticles (AuNPs) were synthesized using β-caryophyllene, a bioactive compound isolated from various plant species. The shape, size, and zeta potential of the synthesized β-c-AuNPs were found to be non-spherical, 17.6 ± 1.2 nm, and -31.76 ± 0.73 mV, respectively. A mixed biofilm of Candida albicans and Staphylococcus aureus was used to test the efficacy of the synthesized β-c-AuNPs. The results revealed a concentration-dependent inhibition of the initial stages of formation of single-species as well as mixed biofilms. Furthermore, β-c-AuNPs also eliminated mature biofilms. Therefore, using β-c-AuNPs to inhibit biofilm and eradicate bacterial-fungal mixed biofilms represents a promising therapeutic approach for controlling polymicrobial infections.

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Antimicrobial effect of gold nanoparticles in the formation of the Staphylococcus aureus biofilm on a polyethylene surface

Cited by 10 publications

References 27 publications

Nano-enabled antimicrobial thin films: design and mechanism of action

Nano-enabled antimicrobial thin films: design and mechanism of action

Advances in Nanotechnology for Biofilm Inhibition

Inhibition of Mixed Biofilms of Candida albicans and Staphylococcus aureus by β-Caryophyllene-Gold Nanoparticles

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