Antimicrobial Effect of Drug Incorporated Nanoparticles Against Oral Pathogens

Abstract

Last few years antibiotics resistance known a major problem that concerns the specialists in the dentistry field due to the improper usage of anti-infectious drugs. Administration of third generation quinolones, levofloxacin (Lev), in dental practice is preferred since has few nonhazardous adverse effects, is used once daily and can be successfully applied as intra-pocket films.This study investigated the possibility of preparing levofloxacin loaded layered double hydroxides nanoparticles in order to enhance antibiotic efficacy against oral pathogens. The nanoparticles obtained under optimal conditions were physico-chemically analyzed and intercalation efficiency was tested. The results of this work revealed that the use of these nanoparticles type levofloxacin loaded layered double hydroxides has the major advantage of prolonged release of the drug, thus allowing an increase of the period between administration and the diminution of side effects of the antibiotic. Further researches should focus on biocompatible properties and antibacterial effect as these nanomaterials supposed to be a sustainable drug delivery system. Keywords: nanoparticles, drug carriers, antibacterial properties, public health dentistry, oral infections