Antimicrobial Drug Discovery: Evident Shifting from Terrestrial to Marine Micro-organisms

Singh, Rajeshwar; Mody, Shailesh K.; Patel, Hasmukh S.; Devi, Sulochana; Sarvaiya, Vaidehi N.; Patel, Himan; Patel, Bhargavi R.

doi:10.20546/ijcmas.2017.605.259

Cited by 5 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ZZ446, in solid medium with sea salt, produced rare diketopiperazine glycosides (Maculosin and maculosin-O-a-L-rhamno-pyranoside (1, 2)), which inhibited MRSA (MIC, 37.0 µg/mL) [32]. However, previously, this bacterium in liquid medium with sea salt, produced streptopyrazinones A-D (1-4), N-acetyl-L-isoleucine-L-leucinamide (5), diketopiperazines (6)(7)(8)(9)(10)(11), and alkaloid (12). Only the new compounds (1-5) were tested and they showed antimicrobial activity against pathogens, including MRSA ATCC 43300 at (MIC, 58.0-65.0 µg/mL) [33].…”

Section: Bacteria From Marine Sedimentsmentioning

confidence: 99%

“…An aromatic polyketides-producing fungus, Penicillium sp. SCSIO 06720 (Indian Ocean), produced 5-[2-hydroxypropane-1-yl]-2,6-dimethlben-zene-1,3-diol (1) and coniochaetone L (2), together with another 19 known compounds (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Only compound 16 exhibited moderate antibacterial activities, including against MRSA-shh-1 at MIC of 46.9 ± 29.7 µg/mL [81].…”

Section: Invertebrate-associated Bacteria (Sponge Ascidian)mentioning

confidence: 99%

“…The extracts from rice fermentation medium of Aspergillus sp. strain SCSIO06786 led to the isolation and identification of fourteen compounds, which include new compounds such as a quinoline alkaloid (1), two bisabolane-type sesquiterpene derivatives (2 and 3), and a new natural product (4), along with another ten known compounds (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Only compound 11-13 exhibited antibacterial activity against the test pathogens, including MRSA at MIC values of 3.13, 12.5, and 12.5 µg/mL [84].…”

Section: Invertebrate-associated Bacteria (Sponge Ascidian)mentioning

confidence: 99%

“…An anti-MRSA novel compounds, 4-methyl-candidusin A (1), aspetritone A (2), and aspetritone B (3), including another 15 already known compounds (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), were identified in the fermentation culture broth of coral (Galaxea fascicularis)-derived fungus, A. tritici SP2-8-1 (Malaysia). Antimicrobial activity testing showed that two strains of MRSA ATCC 43300 and CGMCC 1.12409 were inhibited by aspetritone A (2) and prenylcandidusin at low MIC, while the rest of the compound showed moderate activity [108].…”

Section: Invertebrate-associated Fungi (Sponges Ascidians Crab)mentioning

confidence: 99%

“…The rest is ocean (nearly four kilometres deep on average), home to the marine habitats, which have different temperature and salinity, found in various locations, and is believed to contain organisms with much more extensive phylogenetic diversity. The association of these factors makes the marine habitats a unique and rich source of active compounds for drug production [10].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

et al. 2020

View full text Add to dashboard Cite

As the search for new antibiotics continues, the resistance to known antimicrobial compounds continues to increase. Many researchers around the world, in response to antibiotics resistance, have continued to search for new antimicrobial compounds in different ecological niches such as the marine environment. Marine habitats are one of the known and promising sources for bioactive compounds with antimicrobial potentials against currently drug-resistant strains of pathogenic microorganisms. For more than a decade, numerous antimicrobial compounds have been discovered from marine environments, with many more antimicrobials still being discovered every year. So far, only very few compounds are in preclinical and clinical trials. Research in marine natural products has resulted in the isolation and identification of numerous diverse and novel chemical compounds with potency against even drug-resistant pathogens. Some of these compounds, which mainly came from marine bacteria and fungi, have been classified into alkaloids, lactones, phenols, quinones, tannins, terpenes, glycosides, halogenated, polyketides, xanthones, macrocycles, peptides, and fatty acids. All these are geared towards discovering and isolating unique compounds with therapeutic potential, especially against multidrug-resistant pathogenic microorganisms. In this review, we tried to summarize published articles from 2015 to 2019 on antimicrobial compounds isolated from marine sources, including some of their chemical structures and tests performed against drug-resistant pathogens.

show abstract

Section: Bacteria From Marine Sedimentsmentioning

confidence: 99%

Section: Invertebrate-associated Bacteria (Sponge Ascidian)mentioning

confidence: 99%

Section: Invertebrate-associated Bacteria (Sponge Ascidian)mentioning

confidence: 99%

Section: Invertebrate-associated Fungi (Sponges Ascidians Crab)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

et al. 2020

View full text Add to dashboard Cite

show abstract

Streptocinnamides A and B, Depsipeptides from Streptomyces sp. KMM 9044

et al. 2022

View full text Add to dashboard Cite

The bacterium Streptomyces sp. KMM 9044 from a sample of marine sediment collected in the northwestern part of the Sea of Japan produces highly chlorinated depsiheptapeptides streptocinnamides A (1) and B (2), representatives of a new structural group of antibiotics. The structures of 1 and 2 were determined using nuclear magnetic resonance and mass spectrometry studies and confirmed by a series of chemical transformations. Streptocinnamide A potently inhibits Micrococcus sp. KMM 1467, Arthrobacter sp. ATCC 21022, and Mycobacterium smegmatis MC2 155.

show abstract

Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

Yang

Zhou

et al. 2022

Biomolecules

View full text Add to dashboard Cite

Infectious diseases caused by bacteria and fungi are threatening human health all over the world. It is an increasingly serious problem that the efficacies of some antibacterial and antifungal agents have been weakened by the drug resistance of some bacteria and fungi, which makes a great need for new antibiotics. Sesquiterpenoids, with abundant structural skeleton types and a wide range of bioactivities, are considered as good candidates to be antibacterial and antifungal agents. In the past decades, many sesquiterpenoids were isolated from plants and fungi that exhibited good antibacterial and antifungal activities. In this review, the names, source, structures, antibacterial and antifungal degrees, and mechanisms of sesquiterpenoids with antibacterial and antifungal activity from 2012 to 2022 are summarized, and the structure-activity relationship of these sesquiterpenoids against bacteria and fungi is also discussed.

show abstract

Antimicrobial Drug Discovery: Evident Shifting from Terrestrial to Marine Micro-organisms

Cited by 5 publications

References 29 publications

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

Streptocinnamides A and B, Depsipeptides from Streptomyces sp. KMM 9044

Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

Contact Info

Product

Resources

About