Antimicrobial coating strategy to prevent orthopaedic device-related infections: recent advances and future perspectives

Sulfide-Capped InP/ZnS Quantum Dot Nanoassemblies for a Photoactive Antibacterial Surface

“…This combination can simultaneously generate superoxide radicals and singlet oxygen, potentially increasing the growth inhibition of these bacteria while carefully addressing cytotoxicity concerns. Moreover, it is essential to note that current antibacterial coatings are confined to laboratory research 65 and future efforts should prioritize exploring the clinical translation potential for nosocomial infections. This transition from the laboratory to practical applications in healthcare settings is crucial for the real-world impact of the research.…”

Antibacterial coatings on orthopedic implants

“…With continuous research on controlled releasing-type antibacterial coatings assisted by nanotechnology and combining different preparation techniques (e.g., plasma electrolytic oxidation [ 236 ], electrophoresis [ 237 ], and LbL [ 238 ]) [ 239 , 240 ], multiple nano drug carriers have been developed. By virtue of the ability to enhance drug solubility, modulate drug release, and achieve targeted delivery of multiple drugs, in combination with the advantages of nanoparticles themselves such as small size and large specific surface area, these carriers (mainly including nanotubes, polymer nanocarriers, liposomes, and carbon-based nanocarriers) have become promising antibacterial drug carriers [ 241 , 242 ].…”

“…For example, negatively charged molecules and positively charged antibiotics are prepared by LbL self-assembly into neutrally stable coatings [ [290] , [291] , [292] , [293] ], or acid-sensing bonds (Schiff base bonds [ 294 , 295 ], metal coordination bonds [ 296 ], and borate ester bonds [ 297 , 298 ]) are introduced into preparation. In addition, pH responsive coatings can also be prepared based on the reactive binding between nanoparticles and drugs and the responsive molecules such as polymethacrylic acid (PMAA) [ 240 ].…”

Research progress of stimulus-responsive antibacterial materials for bone infection

“…The high selectivity and biocompatibility of enzyme responsive materials determine that they can play a role in many biomedical applications. As the original trigger factor, the change of specific enzyme expression level can cause enzyme responsive biomaterial reaction and control the release of antibacterial drugs at the required sites, so as to kill bacteria。Enzymes are highly expressed in the infected site, and some specific enzymes were used to identify stimuli, thus achieving the release of antibacterial substances ( Wei et al, 2022 ). Glutamyl endonuclease (V8 enzyme) is a product of Staphylococcus aureus .…”