Antimicrobial Applications of Nanoparticles

Elsawy, Moataz A.; Mostafa, Mohamed H.

doi:10.1002/9781119558026.ch19

Cited by 2 publications

(1 citation statement)

References 193 publications

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“…The antimicrobial properties of nanoparticles are currently being extensively researched, including those with microbicidal properties, such as silver, zinc oxide, copper oxide, zero-valent iron, carbon nanotubes, titanium dioxide, and bio-nanoparticles such as chitosan nanocomposites [ 27 ]. These nanoparticles exhibit remarkable biocidal properties against various microorganisms, while the possibility of the emergence of resistant strains is not a concern [ 28 ]. Physical, chemical, and green processes are used to create nanoparticles [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Anticandidal Effectiveness of Greenly Synthesized Zinc Oxide Nanoparticles with Antifungal Agents against Nosocomial Candidal Pathogens

Yassin,

Al-Otibi,

Al-Askar

et al. 2023

Microorganisms

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The high prevalence of fungal resistance to antifungal drugs necessitates finding new antifungal combinations to boost the antifungal bioactivity of these agents. Hence, the aim of the present investigation was to greenly synthesize zinc oxide nanoparticles (ZnO-NPs) using an aqueous leaf extract of Salvia officinalis and investigate their antifungal activity and synergistic efficiency with common antifungal agents. The biofabricated ZnO-NPs were characterized to detect their physicochemical properties. A disk diffusion assay was employed to investigate the antifungal effectiveness of the greenly synthesized ZnO-NPs and evaluate their synergistic patterns with common antifungal agents. The Candida tropicalis strain was detected to be the most susceptible strain to ZnO-NPs at both tested concentrations of 50 and 100 µg/disk, demonstrating relative suppressive zones of 19.68 ± 0.32 and 23.17 ± 0.45 mm, respectively. The minimum inhibitory concentration (MIC) of ZnO-NPs against the C. tropicalis strain was 40 µg/mL, whereas the minimum fungicidal concentration (MFC) was found to be 80 µg/mL. The highest synergistic efficiency of the biogenic ZnO-NPs with terbinafine antifungal agent was detected against the C. glabrata strain, whereas the highest synergistic efficiency was detected with fluconazole against the C. albicans strain, demonstrating relative increases in fold of inhibition area (IFA) values of 6.82 and 1.63, respectively. Moreover, potential synergistic efficiency was detected with the nystatin antifungal agent against the C. tropicalis strain with a relative IFA value of 1.06. The scanning electron microscopy (SEM) analysis affirmed the morphological deformations of candidal cells treated with the biosynthesized ZnO-NPs as the formation of abnormal infoldings of the cell wall and membranes and also the formation of pores in the cell wall and membranes, which might lead to the leakage of intracellular constituents. In conclusion, the potential synergistic efficiency of the biogenic ZnO-NPs with terbinafine, nystatin, and fluconazole against the tested candidal strains highlights the potential application of these combinations in formulating novel antifungal agents of high antimicrobial efficiency. The biogenic ZnO nanoparticles and antifungal drugs exhibit powerful synergistic efficiency, which highlights their prospective use in the formulation of efficient antimicrobial medications, including mouthwash, ointments, lotions, and creams for effective candidiasis treatment.

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Section: Introductionmentioning

confidence: 99%

Synergistic Anticandidal Effectiveness of Greenly Synthesized Zinc Oxide Nanoparticles with Antifungal Agents against Nosocomial Candidal Pathogens

Yassin,

Al-Otibi,

Al-Askar

et al. 2023

Microorganisms

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Effect of Modification with a Biocide Containing Metal Nanoparticles on Selected LDPE Properties

et al. 2023

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In this work, the physicomechanical, chemical and thermal properties of low-density polyethylene (LDPE) modified with a biocide containing metal nanoparticles: nanoAg, nanoCu, and nanoFe2O3 were examined. The presented studies, apart from the previously proven antimicrobial effectiveness, have shown that the application of the biocide in concentrations of 0.5% and 1% has the least influence on the remaining properties. In the remaining concentrations (2–5%), despite the lack of significant influence on the chemical structure, the biocide primarily influenced the strength properties and melt flow rate (MFR). Previous research showed almost 100% antimicrobiological properties against bacteria and fungi of samples with the addition of 4% biocide. For such samples, the presented studies showed a decrease in MFR by approx. 17%, tensile strength at break by approx. 45%, an increase in elongation at breaking by approx. 25%, a decrease in density >2%, no increase in water absorption, and no significant changes in the chemical structure and in thermal properties in relation to LDPE without biocide.

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Antimicrobial Applications of Nanoparticles

Cited by 2 publications

References 193 publications

Synergistic Anticandidal Effectiveness of Greenly Synthesized Zinc Oxide Nanoparticles with Antifungal Agents against Nosocomial Candidal Pathogens

Synergistic Anticandidal Effectiveness of Greenly Synthesized Zinc Oxide Nanoparticles with Antifungal Agents against Nosocomial Candidal Pathogens

Effect of Modification with a Biocide Containing Metal Nanoparticles on Selected LDPE Properties

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